Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Nicholas M. Boulis"'
Autor:
Colin K. Franz, Thais Federici, Jun Yang, Carey Backus, Sang Su Oh, Qingshan Teng, Erin Carlton, Kathie M. Bishop, Mehdi Gasmi, Raymond T. Bartus, Eva L. Feldman, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 473-481 (2009)
Background: Amyotrophic lateral sclerosis (ALS) is a devastating disease that is characterized by the progressive loss of motor neurons. Patients with ALS usually die from respiratory failure due to respiratory muscle paralysis. Consequently, therapi
Externí odkaz:
https://doaj.org/article/b08a536399554ec89b5daddd1dab6e3b
Autor:
Nicholas M. Boulis, Pavlos Texakalidis, Jonathan Riley, Nathan Hardcastle, Thais Federici, Muhibullah S Tora, Jeremy Wetzel
Publikováno v:
Stereotactic and Functional Neurosurgery. 99:322-328
This manuscript introduces the latest generation of a patient-mounted platform designed for segmental injections of therapeutics direct into the spinal cord parenchyma. It emphasizes its importance and it presents the rationale for developing this de
Autor:
Nicholas M. Boulis
Publikováno v:
Neurosurgery. 66:310-818
Autor:
Anthony Donsante, Peter Canoll, Pavlos Texakalidis, Purva Nagarajan, Kecheng Lei, Muhibullah S Tora, Nicholas M. Boulis, Thais Federici, Stewart G. Neill
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12943
International Journal of Molecular Sciences, Vol 22, Iss 12943, p 12943 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12943, p 12943 (2021)
International Journal of Molecular Sciences
Intramedullary spinal cord tumors are a rare and understudied cancer with poor treatment options and prognosis. Our prior study used a combination of PDGF-B, HRAS, and p53 knockdown to induce the development of high-grade glioma in the spinal cords o
Publikováno v:
Ann Biomed Eng
The neurodegenerative disease amyotrophic lateral sclerosis (ALS) results in the death of motor neurons in voluntary muscles. There are no cures for ALS and few available treatments. In studies with small animal models, injection of cellular therapeu
Autor:
Sarah K. Gross, Zachary T. McEachin, Raymond T. Bartus, Alexandre Betourne, Bo Sung Shim, Dan Deaver, Nicholas M. Boulis, Nicholas J. Maragakis
Publikováno v:
Experimental neurology. 323
Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of reasons, clinical trials of neurotrophic factors have failed to show efficacy in ALS patient
Autor:
Letizia Mazzini, Maurizio Gelati, Daniela Celeste Profico, Gianni Sorarù, Daniela Ferrari, Massimiliano Copetti, Gianmarco Muzi, Claudia Ricciolini, Sandro Carletti, Cesare Giorgi, Cristina Spera, Domenico Frondizi, Stefano Masiero, Alessandro Stecco, Carlo Cisari, Enrica Bersano, Fabiola De Marchi, Maria Francesca Sarnelli, Giorgia Querin, Roberto Cantello, Francesco Petruzzelli, Annamaria Maglione, Cristina Zalfa, Elena Binda, Alberto Visioli, Domenico Trombetta, Barbara Torres, Laura Bernardini, Alessandra Gaiani, Maurilio Massara, Silvia Paolucci, Nicholas M. Boulis, Angelo L. Vescovi, on behalf of the ALS‐NSCs Trial Study Group
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 887-897 (2019)
Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 887-897 (2019)
The main objective of this phase I trial was to assess the feasibility and safety of microtransplanting human neural stem cell (hNSC) lines into the spinal cord of patients with amyotrophic lateral sclerosis (ALS). Eighteen patients with a definite d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2605e229019afd474a5e456fb6f18f8d
http://hdl.handle.net/10281/238647
http://hdl.handle.net/10281/238647
Autor:
Meraida Polak, Lawrence F. Borges, Karl Johe, Seward B. Rutkove, Stephen A. Goutman, Parag G. Patil, Jane Bordeau, Jonathan Riley, Christina Fournier, Jayna Duell, Thais Federici, Jonathan D. Glass, Nicholas M. Boulis, Merit Cudkowicz, Tom Hazel, Vicki S. Hertzberg, Eva L. Feldman, Nazem Atassi
Publikováno v:
Neurology. 87:392-400
Objective: To test the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers. Methods: This open-label trial includ
Autor:
Jonathan Riley, Juanmarco Gutierrez, Pablo Avalos, Joseph H. Miller, Lindsey N. Urquia, Nicholas M. Boulis, Jason J. Lamanna, Thais Federici, Natalia Grin, Carl V. Hurtig, Clive N. Svendsen
Publikováno v:
Neurosurgery. 77:604-612
BACKGROUND Although multiple clinical trials are currently testing different stem cell therapies as treatment alternatives for many neurodegenerative diseases and spinal cord injury, the optimal injection parameters have not yet been defined. OBJECTI
Publikováno v:
Expert opinion on biological therapy. 18(3)
Adeno-associated viral (AAV) vector-mediated gene delivery to the spinal cord has finally entered the pathway towards regulatory approval. Phase 1 clinical trials using AAV gene therapy for pediatric disorders - spinal muscular atrophy (SMA) and gian