Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael T. Wilson"'
Autor:
Peter Nicholls, Brandon J. Reeder, Chris E. Cooper, Michael T. Wilson, Radu Silaghi-Dumitrescu
Publikováno v:
Biochemical Journal. 403:391-395
Ferryl (Fe(IV)=O) species are involved in key enzymatic processes with direct biomedical relevance; among others, the uncontrolled reactivities of ferryl Mb (myoglobin) and Hb (haemoglobin) have been reported to be central to the pathology of rhabdom
Publikováno v:
Antioxidants & Redox Signaling. 6:954-966
Recent research has shown that myoglobin and hemoglobin play important roles in the pathology of certain disease states, such as renal dysfunction following rhabdomyolysis and vasospasm following subarachnoid hemorrhages. These pathologies are linked
Publikováno v:
Biophysical Chemistry. 98:65-77
The iron ligand, Met80, of yeast iso-1-cytochrome c has been mutated to residues that are unable to bind to the iron. The resultant proteins, Met80Ala, Ser, Asp, Glu, have been expressed and purified. All mutant proteins exhibit well defined pH depen
Publikováno v:
Archives of biochemistry and biophysics. 554
Kinetic studies using UV/visible and EPR spectroscopy were carried out to follow the distribution of electrons within beef heart cytochrome c oxidase (CcO), both active and cyanide-inhibited, following addition of reduced cytochrome c as electron don
Autor:
Chris E. Cooper, Jason D. Morrow, Victor M. Darley-Usmar, L. Jackson Roberts, Radhi Anand, David Goodier, Michael T. Wilson, Kevin P. Moore, Martine Clozel, Steve Holt, William E. Zackert, Rakesh P. Patel, Brandon J. Reeder, Dimitri A. Svistunenko
Publikováno v:
Journal of Biological Chemistry. 273:31731-31737
Muscle injury (rhabdomyolysis) and subsequent deposition of myoglobin in the kidney causes renal vasoconstriction and renal failure. We tested the hypothesis that myoglobin induces oxidant injury to the kidney and the formation of F2-isoprostanes, po
Autor:
Michael T. Wilson, Gary Silkstone
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0148369 (2016)
PLoS ONE
PLoS ONE
Using a custom build spectrophotometer equipped with Helmholtz coils and designed to study the effects of magnetic fields on enzyme reactions in real-time we have investigated the influence of fields, from 100 μT to 10 mT and at a variety of field f
Publikováno v:
The Biochemical journal. 434(3)
Cytoglobin is a recently discovered hexa-co-ordinate haemoglobin that does not appear to function as a classical oxygen-binding protein. Its function is unknown and studies on the effects of changes in its expression have not decisively determined it
Autor:
Michael T. Wilson, Alexander J. Howie, John A. Oates, Taneem Amin, Clare K. Carney, D. S. Harry, David W. Wright, Kevin P. Moore, Olivier Boutaud, Shuhe Wang, Brandon J. Reeder, Tina S. Masterson, L. Jackson Roberts
Hemoproteins, hemoglobin and myoglobin, once released from cells can cause severe oxidative damage as a consequence of heme redox cycling between ferric and ferryl states that generates radical species that induce lipid peroxidation. We demonstrate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abb2a8c35a362d794c65f89ef2d2583
https://europepmc.org/articles/PMC2823910/
https://europepmc.org/articles/PMC2823910/
Autor:
Michael T. Wilson, Gunnar Henriksson, Christina Divne, Peter Nicholls, B. Martin Hallberg, Maria G. Mason
Publikováno v:
Biochimica et biophysica acta. 1604(1)
Phanerochaete chrysosporium cellobiose oxidoreductase (CBOR) comprises two redox domains, one containing flavin adenine dinucleotide (FAD) and the other protoheme. It reduces both two-electron acceptors, including molecular oxygen, and one-electron a
Publikováno v:
The Journal of biological chemistry. 273(15)
The reactions of nitric oxide (NO) with fully oxidized cytochrome c oxidase (O) and the intermediates P and F have been investigated by optical spectroscopy, using both static and kinetic methods. The reaction of NO with O leads to a rapid (approxima