Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Soojung Lee"'
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 532, p 532 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 532
International Journal of Molecular Sciences, Vol 23, Iss 532, p 532 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 532
The Na/HCO3 cotransporter NBCe1 is a member of SLC4A transporters that move HCO3− across cell membranes and regulate intracellular pH or transepithelial HCO3 transport. NBCe1 is highly selective to HCO3− and does not transport other anions; the m
Publikováno v:
Oncology Reports
Studies on cultured cancer cells or cell lines have revealed multiple acid extrusion mechanisms and their involvement in cancer cell growth and progression. In the present study, the role of the sodium bicarbonate transporters (NBCs) in prostate canc
Autor:
Jun Ming Li, Lauren A. Jeffers, Soojung Lee, Yejin Kim, Carlos Gonzalez-Islas, Sadie E. Nennig, Jaegwon Chung, Jae-Kyung Lee, Zhe Jin, Jianjun Chang, Ebbe Boedtkjer, Inyeong Choi, Hannah D. Fulenwider, Christian Aalkjaer, Jesse R. Schank
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Schank, J R, Lee, S, Gonzalez-Islas, C E, Nennig, S E, Fulenwider, H D, Chang, J, Li, J M, Kim, Y, Jeffers, L A, Chung, J, Lee, J-K, Jin, Z, Aalkjær, C, Boedtkjer, E & Choi, I 2020, ' Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1 ', Scientific Reports, vol. 10, no. 1, 11017 . https://doi.org/10.1038/s41598-020-67291-0
Scientific Reports
Schank, J R, Lee, S, Gonzalez-Islas, C E, Nennig, S E, Fulenwider, H D, Chang, J, Li, J M, Kim, Y, Jeffers, L A, Chung, J, Lee, J-K, Jin, Z, Aalkjær, C, Boedtkjer, E & Choi, I 2020, ' Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1 ', Scientific Reports, vol. 10, no. 1, 11017 . https://doi.org/10.1038/s41598-020-67291-0
Scientific Reports
The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding the Na/HCO3 transporter NBCn1 suggest that this pH-regulating protein may affect alcohol-related behavior and response. Here, we examined alcohol consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca542b242805b68dde33f0e0fe904f2
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419699
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-419699
Publikováno v:
Physiological Genomics. 49:167-176
Genome-wide association studies have identified the single nucleotide polymorphism (SNP) rs3278 in the human SLC4A7 gene as one of the marker loci for addiction vulnerability. This marker is located in an intron of the gene, and its genomic role has
Autor:
Soojung, Lee, Trine V, Axelsen, Nicolai, Jessen, Stine F, Pedersen, Pernille, Vahl, Ebbe, Boedtkjer
Publikováno v:
Oncogene. 37(41)
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribu
Autor:
C. Chris Yun, Soojung Lee, Yoland Smith, Han Soo Yang, R. Kyle Dudley, Eun Ji Ju, Inyeong Choi, Min Hyung Kwon, Eunjin Kim
Publikováno v:
Cellular Physiology and Biochemistry. 30:1444-1455
Background/Aims: The sodium/bicarbonate transporter NBCn1 plays an essential role in intracellular pH regulation and transepithelial HCO3– movement in the body. NBCn1 also has sodium channel-like activity uncoupled to Na/HCO3 cotransport. We previo
Publikováno v:
Lee, S, Mele, M, Vahl, P, Christiansen, P M, Jensen, V E D & Bødtkjer, E 2015, ' Na+,HCO3--cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane ', Pflügers Archiv-European Journal of Physiology, vol. 467, no. 2, pp. 367-377 . https://doi.org/10.1007/s00424-014-1524-0
Metabolic and biochemical changes during breast carcinogenesis enhance cellular acid production. Extrusion of the acid load from the cancer cells raises intracellular pH, while it decreases extracellular pH creating an inverted pH gradient across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a96d3e9e9b8e903ecacc3f31f6d4cf2
https://pure.au.dk/portal/da/publications/nahco3cotransport-is-functionally-upregulated-during-human-breast-carcinogenesis-and-required-for-the-inverted-ph-gradient-across-the-plasma-membrane(a59484eb-b229-4992-8a50-3357b9f406f2).html
https://pure.au.dk/portal/da/publications/nahco3cotransport-is-functionally-upregulated-during-human-breast-carcinogenesis-and-required-for-the-inverted-ph-gradient-across-the-plasma-membrane(a59484eb-b229-4992-8a50-3357b9f406f2).html
Publikováno v:
Comprehensive Physiology
Cation-coupled HCO3(-) transport was initially identified in the mid-1970s when pioneering studies showed that acid extrusion from cells is stimulated by CO2/HCO3(-) and associated with Na(+) and Cl(-) movement. The first Na(+)-coupled bicarbonate tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1756bc5e93acd3f338196793313ab1a
https://europepmc.org/articles/PMC4768804/
https://europepmc.org/articles/PMC4768804/
Autor:
Andreas A, Danielsen, Mark D, Parker, Soojung, Lee, Walter F, Boron, Christian, Aalkjaer, Ebbe, Boedtkjer
Publikováno v:
The Journal of biological chemistry. 288(12)
Activation of Na(+),HCO3(-) cotransport in vascular smooth muscle cells (VSMCs) contributes to intracellular pH (pH(i)) control during artery contraction, but the signaling pathways involved have been unknown. We investigated whether physical and fun
Autor:
Han Soo, Yang, Deborah S, Cooper, Ira, Rajbhandari, Hae Jeong, Park, Soojung, Lee, Inyeong, Choi
Publikováno v:
Experimental physiology. 94(11)
The Na(+)-HCO(3)(-) cotransporter NBCn1 (SLC4A7) has multiple variants depending upon splice domains in the cytoplasmic amino- and carboxy-termini of the protein. In this study, we examined the role of the amino-terminal splice domain containing 123