Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Piotr Swiderski"'
Autor:
John J. Rossi, Marcin Kortylewski, Chan Gao, Claudia M. Kowolik, Jiehua Zhou, Andrew Raubitschek, Agnieszka Jozwiak, Sergey Nechaev, Brian Armstrong, Piotr Swiderski, Dayson Moreira
Publikováno v:
Journal of Controlled Release
Dicer-substrate siRNAs equipped with CpG oligodeoxyribonucleotides overcome the major hurdle in cell-specific siRNA delivery. The CpG-siRNA molecules are actively internalized by TLR9+ cells, without the need for transfection reagents, leading to RNA
Autor:
Qifang Zhang, Dewan Md Sakib Hossain, Marcin Kortylewski, Sergey Nechaev, Dayson Moreira, Piotr Swiderski
Publikováno v:
Methods in Molecular Biology ISBN: 9781493931118
The SiRNA strategy is a potent and versatile method for modulating expression of any gene in various species for investigational or therapeutic purposes. Clinical translation of SiRNA-based approaches proved challenging, mainly due to the difficulty
Autor:
C. Preston Neff, Ramesh Akkina, Jane Zhang, Jiehua Zhou, Yuanyu Huang, David D. Smith, Quan Du, Ling Peng, Xiaoxuan Liu, Zicai Liang, Piotr Swiderski, Tawfik A. Aboellail, John J. Rossi, Haitang Li
Publikováno v:
Molecular Therapy. 19(12):2228-2238
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small interfering RNA (siRNA) delivery system in a Rag2(-)/-γc-/- (RAG-hu) humanized mouse model for HIV-1 infection. HIV-infected humanized Rag2-/-γc-/- mic
Autor:
Shu-Lian Li, Mahesh Jonnalagadda, Zhong-Gao Xu, Rama Natarajan, Hang Yuan, Linda Lanting, Piotr Swiderski, Sumanth Putta, Mitsuo Kato
Publikováno v:
American Journal of Physiology-Renal Physiology. 295:F605-F617
We previously showed that the 12/15-lipoxygenase (12/15-LO) pathway of arachidonate acid metabolism is involved in multiple events related to diabetic nephropathy (DN), including glomerular hypertrophy and extracellular matrix deposition (Kang SW, Ad
Autor:
Jiehua Zhou, John C. Burnett, Stephen J. Forman, Robert T. Chen, John J. Rossi, Jessica Alluin, Piotr Swiderski, Xizhe Zhang, Katrin Tiemann, Pritsana Chomchan
Publikováno v:
Nucleic Acids Research
The B-cell–activating factor (BAFF)-receptor (BAFF-R) is restrictedly expressed on B-cells and is often overexpressed in B-cell malignancies, such as non-Hodgkin’s lymphoma. On binding to its ligand BAFF, proliferation and cell survival are incre
Autor:
Charles Preston Neff, Ramesh Akkina, David D. Smith, Jiehua Zhou, Piotr Swiderski, Jes Kuruvilla, John J. Rossi, Jane Zhang, Leila Remling, Haitang Li
Publikováno v:
Science translational medicine. 3(66)
Therapeutic strategies designed to treat HIV infection with combinations of antiviral drugs have proven to be the best approach for slowing the progression to AIDS. Despite this progress, there are problems with viral drug resistance and toxicity, ne
Autor:
Haitang Li, Jane Zhang, C. Preston Neff, John J. Rossi, Ramesh Akkina, Jiehua Zhou, Piotr Swiderski
Publikováno v:
Nucleic Acids Research
The envelope glycoprotein of human immunodeficiency virus (HIV) consists of an exterior glycoprotein (gp120) and a trans-membrane domain (gp41) and has an important role in viral entry into cells. HIV-1 entry has been validated as a clinically releva
Publikováno v:
Clinical Cancer Research. 18:B5-B5
Small interfering RNA (siRNA) have been proved to be an effective tool for treating diseases caused by gene expression abnormalities. However, clinical relevance of siRNA technology is compromised by multiple obstacles, such as lack of cellular speci