Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Feijie Zhang"'
Autor:
Huban Kutay, Yong Huang, Paul N. Valdmanis, Mark A. Kay, Kirk Chu, Kalpana Ghoshal, Elizabeth M. Munding, Leszek Lisowski, Feijie Zhang, Yue Zhang, Lan Jin, Shuo Gu
Publikováno v:
Nature Medicine. 22:557-562
Small RNAs can be engineered to target and eliminate expression of disease-causing genes or infectious viruses, resulting in the preclinical and clinical development of RNA interference (RNAi) therapeutics using these small RNAs. To ensure the succes
Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs
Autor:
Lan Jin, Yong Huang, Yue Zhang, Martin Kampmann, Mark A. Kay, Shuo Gu, Feijie Zhang, Michael C. Bassik
Publikováno v:
Kampmann, Martin; Gu, S; Zhang, Y; Jin, L; Huang, Y; Zhang, F; et al.(2014). Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2x9693g0
Nucleic Acids Research
Nucleic Acids Research
The use of RNA interference is becoming routine in scientific discovery and treatment of human disease. However, its applications are hampered by unwanted effects, particularly off-targeting through miRNA-like pathways. Recent studies suggest that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b41bbc335d83bf438ba99e8cde9ff6
http://www.escholarship.org/uc/item/2x9693g0
http://www.escholarship.org/uc/item/2x9693g0
Publikováno v:
Cell. 151(4)
SummaryShort hairpin RNA (shRNA)-induced RNAi is used for biological discovery and therapeutics. Dicer, whose normal role is to liberate endogenous miRNAs from their precursors, processes shRNAs into different biologically active siRNAs, affecting th
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(22)
MicroRNAs and siRNAs interact with target sequences in mRNAs, inducing cleavage- and non-cleavage–based gene repression through the RNA-induced silencing complex (RISC) that consists of one of four mammalian Argonaute proteins, Ago1–Ago4. The pro