Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Conrad Leonard"'
Autor:
Heather Thorne, A-M Patch, John F. Pearson, F Newell, Georgia Chenevix-Trench, Sriganesh Srihari, Vanessa Lakis, Katia Nones, Conrad Leonard, Sunil R. Lakhani, J Beasley, Peter T. Simpson, Michael T. Parsons, Mark A. Ragan, Aimee L Davidson, Amanda B. Spurdle, Andrea Degasperi, K. K. Khanna, Oliver Holmes, Julie K. Johnson, Kaltin Ferguson, Stephen H. Kazakoff, Serena Nik-Zainal, Scott Wood, Nick Waddell, Pamela Mukhopadhyay, Qinying Xu, X. M. De Luca, A.E. McCart Reed, Lynne Reid
Publikováno v:
Cancer Research. 79:P5-10
Approximately 10-15% of breast cancers are associated with a strong family history of disease. Pathogenic variants in BRCA1, BRCA2 or other moderate to highly penetrant susceptibility genes (e.g. TP53, ATM, CHEK2, PALB2 and PTEN) account for a number
Autor:
Robert Van Gulick, James S. Wilmott, Natasa Broit, Jonathan R. Stretch, Vanessa Lakis, John F. Thompson, Stephen H. Kazakoff, Graham J. Mann, Oliver Holmes, Richard A. Scolyer, Nicola Waddell, Rene Gonzalez, Peter Johansson, Carol M. Amato, Mitchell P. Levesque, Peter M. Ferguson, John V. Pearson, Andrew J. Spillane, Robyn P. M. Saw, Conrad Leonard, Ann-Marie Patch, Katia Nones, Robert V. Rawson, Nicholas K. Hayward, Venkateswar Addala, Scott Wood, Georgina V. Long, Karl D. Lewis, Lambros T. Koufariotis, Theresa Medina, Tristan J. Dodds, Pamela Mukhopadhyay, Felicity Newell, William A. Robinson, Qinying Xu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
To increase understanding of the genomic landscape of acral melanoma, a rare form of melanoma occurring on palms, soles or nail beds, whole genome sequencing of 87 tumors with matching transcriptome sequencing for 63 tumors was performed. Here we rep
Autor:
Anna Fitzgerald, John V. Pearson, Andrew J. Spillane, Loretta Lau, Nuria Lopez-Bigas, Peter Johansson, Catherine A. Shang, Richard A. Scolyer, John F. Thompson, Scott Wood, Valerie Jakrot, Peter Hersey, Katia Nones, Rebecca A. Dagg, Antonia L. Pritchard, Conrad Leonard, Andreas Behren, Varsha Tembe, Robyn P. M. Saw, Loris Mularoni, Nick Waddell, Mark Shackleton, Hojabr Kakavand, Ping Shang, Jean Y. Yang, Graham J. Mann, Radhakrishnan Sabarinathan, Gulietta M. Pupo, Ricardo De Paoli-Iseppi, Jonathan Cebon, Richard F. Kefford, Ricardo E. Vilain, Hilda A. Pickett, Stephen H. Kazakoff, Ludmil B. Alexandrov, Oliver Holmes, Nicholas K. Hayward, Nicola Waddell, Ken Dutton-Regester, Jonathan R. Stretch, Sean M. Grimmond, Felicity Newell, Qinying Xu, James S. Wilmott, Hazel Burke, Georgina V. Long, Sarah-Jane Schramm, Matthew A. Field, Ann-Marie Patch
Publikováno v:
Nature
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cuta
Autor:
Stephen H. Kazakoff, Julie Johnson, Nicola Waddell, Oliver Holmes, Sunil R. Lakhani, K. K. Khanna, Conrad Leonard, Michael T. Parsons, Peter T. Simpson, Vanessa Lakis, Katia Nones, Serena Nik-Zainal, Aimee L Davidson, Scott Wood, Andrea Degasperi, Georgia Chenevix-Trench, A.E. McCart Reed, Lynne Reid, John V. Pearson, Ann-Marie Patch, Kaltin Ferguson, X. M. De Luca, Sriganesh Srihari, Jonathan M. Harris, Jonathan Beesley, Mark A. Ragan, David G. Barnes, Heather Thorne, Pamela Mukhopadhyay, Felicity Newell, Qinying Xu, Amanda B. Spurdle
Publikováno v:
Ann Oncol
Background Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of the somatic mutation burden of tumours. Here, we investigated the utility of tumour and matched germline WGS for understanding aetiology and t
Autor:
Amy Ellen, McCart Reed, Emarene, Kalaw, Katia, Nones, Mark, Bettington, Malcolm, Lim, James, Bennett, Kate, Johnstone, Jamie Rose, Kutasovic, Jodi Marie, Saunus, Stephen, Kazakoff, Qinying, Xu, Scott, Wood, Oliver, Holmes, Conrad, Leonard, Lynne Estelle, Reid, Debra, Black, Colleen, Niland, Kaltin, Ferguson, Irma, Gresshoff, Ashwini, Raghavendra, Kate, Harvey, Caroline, Cooper, Cheng, Liu, Lauren, Kalinowski, Andrew Scott, Reid, Morgan, Davidson, John V, Pearson, Nirmala, Pathmanathan, Gary, Tse, David, Papadimos, Rajadurai, Pathmanathan, Gavin, Harris, Rin, Yamaguchi, Puay Hoon, Tan, Stephen B, Fox, Sandra A, O'Toole, Peter Thomas, Simpson, Nicola, Waddell, Sunil R, Lakhani
Publikováno v:
Cancer Informatics
Metaplastic breast carcinoma (MBC) is relatively rare but accounts for a significant proportion of global breast cancer mortality. This group is extremely heterogeneous and by definition exhibits metaplastic change to squamous and/or mesenchymal elem
Autor:
Mythily Mariasegaram, Ann-Marie Patch, Conrad Leonard, Admire Matsika, Sean M. Grimmond, Fares Al-Ejeh, Margaret C. Cummings, Rosalind L. Jeffree, Georgia Chenevix-Trench, Oliver Holmes, Leonard Da Silva, Nur Aishah Taib, Adrienne M. Flanagan, Teresa K. Withers, Matthew J. Anderson, Vairavan Narayanan, Ehsan Nourbakhsh, Queenie Lau, Sunil R. Lakhani, J. Lynn Fink, kConFab, Felicity Newell, Katia Nones, Stephen H. Kazakoff, Colleen Niland, Parmjit S. Jat, Ivon Harliwong, Peter T. Simpson, Lynne Reid, Nicola Waddell, Soo Hwang Teo, Karin S. Kassahn, Sebastian Brandner, John V. Pearson, Nick Waddell, Qinying Xu, Scott Wood, Darrin Taylor, Senel Idrisoglu, Peter Wilson, Timothy J. C. Bruxner, Kum Kum Khanna, Craig Nourse, Shivangi Wani, Angelika N. Christ, David Miller, Amy E. McCart Reed, Michael C.J. Quinn, Yock Ping Chow, Jodi M. Saunus, Suzanne Manning, Peter Bailey
Publikováno v:
The Journal of Pathology. 237:363-378
Treatment options for patients with brain metastases (BMs) have limited efficacy and the mortality rate is virtually 100%. Targeted therapy is critically under-utilized, and our understanding of mechanisms underpinning metastatic outgrowth in the bra