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pro vyhledávání: '"Neil K. Gibbs"'
Autor:
Neil K. Gibbs
Publikováno v:
The Journal of Nutrition. 150:2576S-2579S
Atopic dermatitis (AD) is an incurable, inflammatory skin condition that is prevalent (∼20%) in young children. There is an unmet clinical need, particularly in children, for safe interventions that target the etiology of the disease. Deficiencies
Autor:
Neil K. Gibbs, Rachel E.B. Watson, Christopher E.M. Griffiths, Sarah A. Hibbert, Michael J. Sherratt
Publikováno v:
Hibbert, S, Watson, R, Griffiths, C, Gibbs, N & Sherratt, M 2019, ' Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins ', Cell Signal, vol. 54, pp. 191-199 . https://doi.org/10.1016/j.cellsig.2018.11.024
Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f34e84c80fdbdb67169eb6e318d0dc
https://linkinghub.elsevier.com/retrieve/pii/S0898656818303024
https://linkinghub.elsevier.com/retrieve/pii/S0898656818303024
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Autor:
Rachel E.B. Watson, Sarah A. Hibbert, Christopher E.M. Griffiths, Neil K. Gibbs, Anthony S. Weiss, Patrick Costello, Clair Baldock, Michael J. Sherratt
Publikováno v:
Redox Biology, Vol 5, Iss, Pp 101-113 (2015)
Redox Biology
Redox Biology
Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration,
Autor:
Suzanne M, Pilkington, Neil K, Gibbs, Patrick, Costello, Susan P, Bennett, Karen A, Massey, Peter S, Friedmann, Anna, Nicolaou, Lesley E, Rhodes
Publikováno v:
Experimental dermatology. 25(12)
Langerhans cells (LCs) are sentinels of skin's immune system, their loss from epidermis contributing to UVR suppression of cell-mediated immunity (CMI). Omega-3 polyunsaturated fatty acids show potential to reduce UVR suppression of CMI in mice and h
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 22:297-303
BACKGROUND: Ultraviolet (UV) radiation damages the cellular DNA of skin cells. In response, wild-type p53 protein accumulates in irradiated cells and the stabilized and transactivated protein can then induce genes involved in cell cycle arrest in G1,
Publikováno v:
Antioxidantsredox signaling. 21(7)
Chronic exposure to environmental ultraviolet radiation (UVR) plays a key role in both photocarcinogenesis and induction of accelerated skin aging. Although the spatiotemporal consequences of UVR exposure for the composition and architecture of the d
Autor:
Neil K. Gibbs, Samantha Kidd, Nicola J. Traynor, Laurent Marrot, Jean Roch Meunier, Catherine Agapakis-Causse
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 58:26-31
The fluoroquinolone antibiotic, lomefloxacin, is phototoxic in human skin exposed to UVA radiation, photosensitises DNA strand breaks and pyrimidine dimers in human keratinocytes in vitro, and is phototumorigenic in mouse skin. The p53 tumour suppres
Autor:
Naser M. I. Al-Aasswad, Neil K. Gibbs, Lesley E. Rhodes, S Bennett, Anna Nicolaou, Karen A. Massey, Peter S. Friedmann, Suzanne M. Pilkington, Khaled Roshdy
Publikováno v:
The American journal of clinical nutrition. 97(3)
BACKGROUND: Skin cancer is a major public health concern, and the majority of cases are caused by solar ultraviolet radiation (UVR) exposure, which suppresses skin immunity. Omega-3 (n-3) PUFAs protect against photoimmunosuppression and skin cancer i
Publikováno v:
Photochemistry and Photobiology. 63:302-305
Trans-urocanic acid (UCA) is found in the upper layer of the skin and UV irradiation induces its photoisomerization to cis-UCA. Cis-UCA mimics some of the immunosuppressive properties of UV exposure. The wavelength dependence for in vitro photoisomer
Autor:
Neil K, Gibbs, Mary, Norval
Publikováno v:
Photodermatology, photoimmunologyphotomedicine. 29(2)
Exposure to ultraviolet radiation can lead to suppression of many adaptive immune responses, both to antigens encountered within a short period of the irradiation (primary) and to antigens previously encountered (memory). The pathways involved are co