Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Yassine Amrani"'
Autor:
Peter Bradding, Latifa Chachi, Yassine Amrani, Reynold A. Panettieri, Cynthia Koziol-White, Abdulrahman Alzahrani, Michael Biddle, Rehab Bagadood
Publikováno v:
Clinical and experimental immunology. 194(2)
Summary The purpose of this study was to investigate whether growth factors produced by activated human lung mast cells (HLMCs) impair β2-adrenoceptor (β2-AR) function in human airway smooth muscle (ASM) cells. Protein array analysis confirmed the
Autor:
John David Ganther, Alaa Khatib, Omar Tliba, Blerina Kokalari, Danielle O'Connell, Belaid Bouazza, Yassine Amrani
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 309:L348-L359
Although the majority of patients with asthma are well controlled by inhaled glucocorticoids (GCs), patients with severe asthma are poorly responsive to GCs. This latter group is responsible for a disproportionate share of health care costs associate
Autor:
Yassine Amrani, Michael A. Thompson, Hitesh Pandya, Rodney D. Britt, Vivian M. Chu, Arij Faksh, Y. S. Prakash, Richard J. Martin, Elizabeth R. Vogel, Christina M. Pabelick
Publikováno v:
Journal of Cellular Physiology. 230:1189-1198
Asthma in the pediatric population remains a significant contributor to morbidity and increasing healthcare costs. Vitamin D3 insufficiency and deficiency have been associated with development of asthma. Recent studies in models of adult airway disea
Autor:
Lauren Isaacs, Omar Tliba, Belaid Bouazza, Yassine Amrani, Danielle Formella, Danielle O'Connell, Sara Ahamed, Manel Debba-Pavard
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 50:301-315
Like many steroid receptors, the glucocorticoid (GC) receptor (GR) is a phosphoprotein. Although there are multiple phosphorylation sites critical for GR transcriptional activity (i.e., serine [S]203, S211, and S226), their respective role in driving
Autor:
Timothy Macedo-Hatch, Michel Bouvier, Julie-Myrtille Bourgognon, Kian Fan Chung, Adrian J. Butcher, Eugénie Goupil, Stéphane A. Laporte, Christian LeGouill, Kirsty E. Russell, Kok Choi Kong, Gabriele M. König, Bianca Plouffe, Sophie J. Bradley, Andrew B. Tobin, Coen Wiegman, Yassine Amrani, Max Maza Iglesias, Evi Kostenis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(16)
G protein-coupled receptors (GPCRs) are known to initiate a plethora of signaling pathways in vitro. However, it is unclear which of these pathways are engaged to mediate physiological responses. Here, we examine the distinct roles of Gq/11-dependent
Autor:
Yassine Amrani, Hitesh Pandya, Helen Pearson, Christine M. Pabelick, Rodney D. Britt, Y. S. Prakash
Adult human airway smooth muscle (ASM) produce cytokines involved in recruitment and survival of leukocytes within airway walls. Cytokine generation by adult ASM is glucocorticoid-sensitive. Whether developing lung ASM produces cytokines in a glucoco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212cb9c4fb50bf1faf8d2fe227668ee7
https://europepmc.org/articles/PMC4725051/
https://europepmc.org/articles/PMC4725051/
Publikováno v:
Current Pharmaceutical Design. 17:667-673
Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale fo
Autor:
Yassine Amrani, Omar Tliba
Publikováno v:
Proceedings of the American Thoracic Society. 5:106-112
The present article will describe the potential role of airway smooth muscle (ASM) in mediating both deleterious/beneficial effects of interferons (IFNs) in asthma. First described as beneficial in treating the main features of asthma, the interplay
Autor:
Elena A. Goncharova, Vera P. Krymskaya, Gregory Cesarone, Matthew Spaits, Omar Tliba, Amelia Chisolm, Reynold A. Panettieri, Dmitry A. Goncharov, Irene Khavin, Poay N. Lim, Yassine Amrani
Publikováno v:
Molecular Pharmacology. 73:778-788
Lymphangioleiomyomatosis (LAM), a rare pulmonary disorder, manifests as an abnormal neoplastic growth of smooth muscle-like cells within the lungs. Mutational inactivation of tumor suppressor tuberous sclerosis complex 2 (TSC2) in LAM constitutively
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 45(11)
Growing in vivo evidence supports the concept that airway smooth muscle produces various immunomodulatory factors that could contribute to asthma pathogenesis via the regulation of airway inflammation, airway narrowing and remodelling. Targeting ASM