Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ya-Ting Yang"'
Publikováno v:
Frontiers in Bioscience. :72-85
Alzheimer's disease (AD) is the most common form of dementia with a progressive course. AD pathology is a manifestation of the underlying severity and neuroanatomic involvement of specific vulnerable brain regions and circuits that are responsible fo
Autor:
Ya-Ting Yang, Steve Leu, Chon-Kit Chou, Chien-Chih Chiu, Yu-Ting Chang, Michal Korinek, I-Ling Lin, Chin-Ju Tang, Yei Tsung Chen
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 5, p 902 (2017)
International Journal of Molecular Sciences, Vol 18, Iss 5, p 902 (2017)
Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains
Autor:
Shih Hsuan Huang, Po Lin Liao, Ching Hao Li, Jaw Jou Kang, Ya Ting Yang, Yu Wen Cheng, Cheng Hui Lin
Publikováno v:
Archives of Toxicology.
Hypoxia-mediated stress responses are important in tumor progression, especially when tumor growth causes the tumor to become deprived of its blood supply. The oxygen-labile transcription factor hypoxia-inducible factor-1 alpha (HIF-1α) plays a crit
Publikováno v:
Toxicological Sciences
Overuse and abuse of antibiotics can increase the risk of cancer. Chloramphenicol can inhibit both bacterial and mitochondrial protein synthesis, causing mitochondrial stress and decreased ATP biosynthesis. Chloramphenicol can accelerate cancer progr
Publikováno v:
Molecular nutritionfood research. 53(3)
Resveratrol (3,5,4'-trihydroxystilbene) is a natural polyphenol that presents various physiological activities. It has been reported that the methylated derivatives of resveratrol show better potential antifungal and antiproliferative activities than
Publikováno v:
Journal of neurochemistry. 93(3)
Compromised mitochondrial function in neurons and glia has been observed in several neurodegenerative disorders, including Huntington's disease and Alzheimer's disease. Chemical/hypoxic preconditioning may afford protection against subsequently more
Autor:
Ho-Pi Lin, Samuel K. Kulp, Ping-Hui Tseng, Ya-Ting Yang, Chi-Cheng Yang, Chang-Shi Chen, Ching-Shih Chen
Publikováno v:
Molecular cancer therapeutics. 3(12)
Evidence suggests that the angiogenic endothelium represents an important target through which celecoxib mediates in vivo antitumor effects. Nevertheless, the pharmacologic basis for celecoxib-caused growth inhibition in endothelial cells in vitro re
Publikováno v:
Journal of medicinal chemistry. 47(18)
The alpha1-adrenoreceptor antagonist doxazosin induces apoptosis in malignant cells with moderate potency via an alpha1-adrenoreceptor-independent mechanism. Here, we demonstrate that the ability of doxazosin to induce apoptosis in PC-3 prostate canc
Autor:
Ching Shih Chen, Chung Wai Shiau, Ya Ting Yang, Yeng Jeng Shaw, Ping Hui Tseng, Samuel K. Kulp, Jui Wen Huang, Joseph W. Fowble, Jiuxiang Zhu
Publikováno v:
Cancer research. 64(12)
The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celecoxib mediates apoptosis. Celecoxib, however, is a weak PDK-1 inhibitor (IC50, 48 μm), requirin
Autor:
Chin-Chun Hung, Samuel K. Kulp, Joseph W. Fowble, Ju Ping Lai, Patrick J Ward, Kuen-Feng Chen, Ping Hui Tseng, Ching Shih Chen, Ya Ting Yang
Publikováno v:
Cancer research. 64(4)
Regarding the involvement of cyclooxygenase-2 (COX-2)-independent pathways in celecoxib-mediated antineoplastic effects, the following two issues remain outstanding: identity of the non-COX-2 targets and relative contributions of COX-2-dependent vers