Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ulf R, Rapp"'
Autor:
Nefertiti El-Nikhely, Soni Savai Pullamsetti, Friedrich Grimminger, Ulf R. Rapp, Indrabahadur Singh, Astrid Wietelmann, Andreas Weigert, Annika Karger, Guillermo Barreto, Reinhard Dammann, Poonam Sarode, Werner Seeger, Ludger Fink, Rajkumar Savai, Thorsten Stiewe
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2020, 80 (19), pp.4199-4211. ⟨10.1158/0008-5472.CAN-20-1158⟩
Cancer Research, American Association for Cancer Research, 2020, 80 (19), pp.4199-4211. ⟨10.1158/0008-5472.CAN-20-1158⟩
Although NF-κB is known to play a pivotal role in lung cancer, contributing to tumor growth, microenvironmental changes, and metastasis, the epigenetic regulation of NF-κB in tumor context is largely unknown. Here we report that the IKK2/NF-κB sig
Publikováno v:
The FOS and JUN Families of Transcription Factors ISBN: 9780203710036
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6437d63ed3f0e7a06849b4fc928b846
https://doi.org/10.1201/9780203710036-20
https://doi.org/10.1201/9780203710036-20
Autor:
Axel Ullrich, Ulf R. Rapp, Katharina Weidmann, Rajkumar Savai, Verena Pfeiffer, Nefertiti El-Nikhely, Emanuele Zanucco, Rudolf Götz, Werner Seeger
Publikováno v:
Journal of Biological Chemistry. 289:26804-26816
Tumors are often greatly dependent on signaling cascades promoting cell growth or survival and may become hypersensitive to inactivation of key components within these signaling pathways. Ras and RAF mutations found in human cancer confer constitutiv
Autor:
Laxmikanth Kollipara, Ulf R. Rapp, Claudia Sibilski, René P. Zahedi, Angela Baljuls, Thomas D. Mueller, Thomas Rudel
Publikováno v:
Journal of Biological Chemistry. 288:35237-35252
In metazoans, the highly conserved MAPK signaling pathway regulates cell fate decision. Aberrant activation of this pathway has been implicated in multiple human cancers and some developmental disorders. KSR1 functions as an essential scaffold that b
Autor:
Ulf R. Rapp, Tripat Kaur Oberoi-Khanuja, Krishnaraj Rajalingam, Christiaan Karreman, Sarit Larisch
Publikováno v:
Journal of Biological Chemistry. 287:28445-28455
Inhibitor of apoptosis (IAPs) proteins are characterized by the presence of evolutionarily conserved baculoviral inhibitor of apoptosis repeat (BIR) domains, predominantly known for their role in inhibiting caspases and, thereby, apoptosis. We have s
Autor:
Mirko Hekman, Lisa Polzien, Thomas Müller, Inge Schwarzenau, Regina Mahr, Ulf R. Rapp, Angela Baljuls
Publikováno v:
Journal of Biological Chemistry. 286:16491-16503
The serine/threonine kinase RAF is a central component of the MAPK cascade. Regulation of RAF activity is highly complex and involves recruitment to membranes and association with Ras and scaffold proteins as well as multiple phosphorylation and deph
Autor:
Ulf R. Rapp, Angela Baljuls, Heide-Marie Roth, Lisa Polzien, Kristian Schweimer, Jochen Kuper, Mirko Hekman, Roland Benz
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1810:162-169
Background BAD protein (Bcl-2 antagonist of cell death) belongs to the BH3-only subfamily of proapoptotic proteins and is proposed to function as the sentinel of the cellular health status. Physiological activity of BAD is regulated by phosphorylatio
Publikováno v:
Advances in Enzyme Regulation. 50:147-159
Autor:
Nadiya Byts, Anatoly Samoylenko, Hannelore Ehrenreich, Anna-Leena Sirén, Krishnaraj Rajalingam, Ulf R. Rapp, Nicolas von Ahsen
Publikováno v:
Cellular Signalling. 20:154-162
Thrombopoietin (TPO), a hematopoietic growth factor regulating platelet production, and its receptor (TPOR) were recently shown to be expressed in the brain where they exert proapoptotic activity. Here we used PC12 cells, an established model of neur