Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tetsuya Hosooka"'
Autor:
Daisuke Kohno, Gerard Karsenty, Wataru Ogawa, Kazuhiro Nomura, Tetsuya Hosooka, Naoki Kuramoto, Tadahiro Kitamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key componen
Autor:
Tetsuya, Hosooka, Yusei, Hosokawa, Kaku, Matsugi, Masakazu, Shinohara, Yoko, Senga, Yoshikazu, Tamori, Chikako, Aoki, Sho, Matsui, Tsutomu, Sasaki, Tadahiro, Kitamura, Masashi, Kuroda, Hiroshi, Sakaue, Kazuhiro, Nomura, Kei, Yoshino, Yuko, Nabatame, Yoshito, Itoh, Kanji, Yamaguchi, Yoshitake, Hayashi, Jun, Nakae, Domenico, Accili, Takehiko, Yokomizo, Susumu, Seino, Masato, Kasuga, Wataru, Ogawa
Publikováno v:
Proc Natl Acad Sci U S A
Although adipocytes are major targets of insulin, the influence of impaired insulin action in adipocytes on metabolic homeostasis remains unclear. We here show that adipocyte-specific PDK1 (3′-phosphoinositide–dependent kinase 1)-deficient (A-PDK
Autor:
Yuko Okada, Wataru Ogawa, Shin'ichi Takeda, Tetsuya Hosooka, Kenta Kobayashi, Yasuhiko Minokoshi, Michihiro Imamura, Yoko Senga, Kazuhiro Nomura, Shiki Okamoto, Yu Hirata
Diabetes mellitus is associated with various disorders of the locomotor system including the decline in mass and function of skeletal muscle. The mechanism underlying this association has remained ambiguous, however. We now show that the abundance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c01fa4131a11ef979de9870c8277088
https://europepmc.org/articles/PMC6478420/
https://europepmc.org/articles/PMC6478420/
Autor:
Takaya Satoh, Nobuyuki Takenaka, Keiko Matsuda, Yukio Sumi, Tetsuya Noguchi, Junko Fujita, Tetsuya Hosooka, Atsu Aiba
Publikováno v:
Biochemical Journal. 469(3):445-454
application/pdf
Biochemical Journal. 2015, 469 (3), P.445-454
Biochemical Journal. 2015, 469 (3), P.445-454
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine. 74
Autor:
Anny Usheva, David A. Phillips, Hiroshi Maruyama, Ann Hammarstedt, Ulf Smith, Barbara B. Kahn, Bettina J. Kraus, Mark M. Yore, Tetsuya Hosooka, Julie Norseen, Shashi Kant, Roger J. Davis, Pratik Aryal, Urban A. Kiernan
Publikováno v:
Molecular and Cellular Biology. 32:2010-2019
Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovascular disease. Elevated serum R
Autor:
Kazuki Yasuda, Yasushi Matsuki, Michihiro Matsumoto, Mashito Sakai, Tetsuya Noguchi, Ryuji Hiramatsu, Hiroshi Inoue, Kazuo Takazawa, Tetsuya Hosooka, Masato Kasuga, Yoshiaki Kido, Tomoko Tujimura, Kenjiro Inagaki, Cao Yongheng
Publikováno v:
Nature Medicine. 18:612-617
During fasting, induction of hepatic gluconeogenesis is crucial to ensure proper energy homeostasis. Such induction is dysregulated in type 2 diabetes, resulting in the development of fasting hyperglycemia. Hormonal and nutrient regulation of metabol
Autor:
Tetsuya Hosooka, Wataru Ogawa
Publikováno v:
Diabetology International. 3:65-67
Resveratrol, a natural polyphenol first identified and named by a Japanese chemist in 1940 [1], is present in many plant products, including grape skin. It has been the focus of much attention recently because it provides a variety of potential healt
Autor:
Yuma Nihata, Tetsuya Noguchi, Junyuan Wu, Takaya Satoh, Nobuyuki Takenaka, Tetsuya Hosooka, Wataru Ogawa, Atsu Aiba, Rumi Izawa, Kaho Kitagawa
Publikováno v:
The FEBS journalReferences. 281(5)
Insulin promotes glucose uptake in skeletal muscle by inducing the translocation of the glucose transporter GLUT4 to the plasma membrane. The serine/threonine kinase Akt2 has been implicated as a key regulator of this insulin action. However, the mec
Autor:
Kazuo, Takazawa, Tetsuya, Noguchi, Tetsuya, Hosooka, Toyo, Yoshioka, Kazutoshi, Tobimatsu, Masato, Kasuga
Publikováno v:
The Kobe journal of medical sciences. 54(1)
Insulin induces translocation of the glucose transporter GLUT4 from intracellular storage compartment to the plasma membrane via complex mechanisms that require intact cytoskeletal networks. In cultured adipocytes, conventional kinesin motor proteins