Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rossella Manfredini"'
Autor:
Matteo Lulli, Alessandro M. Vannucchi, Manjola Balliu, Niccolò Bartalucci, Rossella Manfredini, Laura Calabresi, Laura Maggi, Paola Guglielmelli, Simone Romagnoli
Publikováno v:
Blood Adv
Calreticulin (CALR), an endoplasmic reticulum–associated chaperone, is frequently mutated in myeloproliferative neoplasms (MPNs). Mutated CALR promotes downstream JAK2/STAT5 signaling through interaction with, and activation of, the thrombopoietin
Autor:
Chiara Rossi, Roberta Zini, Sebastiano Rontauroli, Samantha Ruberti, Zelia Prudente, Greta Barbieri, Elisa Bianchi, Simona Salati, Elena Genovese, Niccolò Bartalucci, Paola Guglielmelli, Enrico Tagliafico, Vittorio Rosti, Giovanni Barosi, Alessandro M. Vannucchi, Rossella Manfredini, the AGIMM (AIRC‐Gruppo Italiano Malattie Mieloproliferative) investigators
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Molecular Oncology, Vol 12, Iss 12, Pp 2102-2123 (2018)
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by an excessive production of pro-inflammatory cytokines resulting in chronic inflammation and genomic instability. Besides the driver mutations in JAK2, MPL, and CALR genes,
Autor:
Anna, Chorzalska, John, Morgan, Nagib, Ahsan, Diana O, Treaba, Adam J, Olszewski, Max, Petersen, Nathan, Kingston, Yan, Cheng, Kara, Lombardo, Christoph, Schorl, Xiaoqing, Yu, Roberta, Zini, Annalisa, Pacilli, Alexander, Tepper, Jillian, Coburn, Anita, Hryniewicz-Jankowska, Ting C, Zhao, Elena, Oancea, John L, Reagan, Olin, Liang, Leszek, Kotula, Peter J, Quesenberry, Philip A, Gruppuso, Rossella, Manfredini, Alessandro Maria, Vannucchi, Patrycja M, Dubielecka
Publikováno v:
Blood. 132(19)
Although the pathogenesis of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs) is linked to constitutive activation of the JAK-STAT pathway, JAK inhibitors have neither curative nor MPN-stem cell-eradicating potential, indicat
Autor:
Anna Chorzalska, Yan Cheng, Roberta Zini, Xiaoqing Yu, Rossella Manfredini, Max Petersen, Anita Hryniewicz-Jankowska, John Morgan, Diana O. Treaba, Nathan Kingston, Alexander Tepper, Elena Oancea, Adam J. Olszewski, Jillian Coburn, Philip A. Gruppuso, Olin D Liang, Alessandro M. Vannucchi, Peter J. Quesenberry, Nagib Ahsan, Annalisa Pacilli, Leszek Kotula, John L. Reagan, Kara Lombardo, Patrycja M. Dubielecka, Ting C. Zhao, Christoph Schorl
Although the pathogenesis of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs) is linked to constitutive activation of the JAK-STAT pathway, JAK inhibitors have neither curative nor MPN-stem cell-eradicating potential, indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4408f3c04d0a5484b426e1648faeb3bf
http://www.bloodjournal.org/content/bloodjournal/132/19/2053.full.pdf
http://www.bloodjournal.org/content/bloodjournal/132/19/2053.full.pdf
Autor:
Carmela Mannarelli, Elisa Bianchi, Paola Guglielmelli, Niccolò Bartalucci, Sebastiano Rontauroli, Samantha Ruberti, Chiara Rossi, Chiara Carretta, Rossella Manfredini, Elena Genovese, Zelia Prudente, Simona Salati, Valentina Pennucci, Alessandro M. Vannucchi, Roberta Zini, Enrico Tagliafico
Publikováno v:
Blood. 132:4332-4332
Somatic mutations of calreticulin (CALR) have been described in approximately 30-40% of JAK2 and MPL unmutated Essential Thrombocythemia and Primary Myelofibrosis patients. CALR is an endoplasmic reticulum (ER) chaperone responsible for proper protei
Autor:
Rossella Manfredini, Andrea Bisognin, Ruggiero Norfo, Alessandro M. Vannucchi, Flavia Biamonte, Stefania Bortoluzzi, Marta Biasolo, Paola Guglielmelli
Publikováno v:
Blood. 119:e120-e130
To gain insights into a possible role of microRNAs in myeloproliferative neoplasms, we performed short RNA massive sequencing and extensive bioinformatic analysis in the JAK2V617F-mutated SET2 cell line. Overall, 652 known mature miRNAs were detected
Autor:
Lara Rossi, Rossella Manfredini, Davide Ferrari, Roberto M. Lemoli, Valentina Salvestrini, Marilena Ciciarello, Roberta Zini
Extracellular nucleotides are potent signaling molecules mediating cell-specific biological functions, mostly within the processes of tissue damage and repair and flogosis. We previously demonstrated that adenosine 5'-triphosphate (ATP) inhibits the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a9e4657fb73b9c3801f1b262921e64
https://hdl.handle.net/11380/979703
https://hdl.handle.net/11380/979703
Autor:
Michele Baccarani, Davide Ferrari, Giorgia Migliardi, Maria Rosaria Ricciardi, Roberta Zini, Rossella Manfredini, Elisa Bianchi, Sara Gulinelli, Sergio Ferrari, Roberto M. Lemoli, Agostino Tafuri, Wanda Piacibello, Francesco Di Virgilio, Simona Salati, Luisa Caione, Valentina Salvestrini, Marco Romano, Lara Rossi
Publikováno v:
Blood; Vol 119
Blood
Blood
Extracellular ATP and UTP nucleotides increase the proliferation and engraftment potential of normal human hematopoietic stem cells via the engagement of purinergic receptors (P2Rs). In the present study, we show that ATP and UTP have strikingly oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2ead111b418b2679896b6834684e27
http://hdl.handle.net/11567/608561
http://hdl.handle.net/11567/608561
Autor:
Valentina Salvestrini, Wanda Piacibello, Roberta Zini, Francesco Di Virgilio, Rossella Manfredini, Sergio Ferrari, Roberto M. Lemoli, Giovanna Lucchetti, Luisa Caione, Davide Ferrari, Marco Idzko, Marilena Ciciarello, Lara Rossi, Sara Gulinelli
Publikováno v:
Experimental hematology. 39(3)
OBJECTIVE: Extracellular adenosine triphosphate (ATP) is a well-recognized mediator of cell-to-cell communication. Here we show ATP effects on bone marrow (BM)-derived human mesenchymal stem cell (hMSCs) functions. MATERIALS AND METHODS: ATP-induced
Autor:
Rossella Manfredini, Davide Ferrari, Sara Gulinelli, Roberta Zini, Miriam Fogli, Francesco Bertolini, Sergio Ferrari, Roberto M. Lemoli, Francesco Di Virgilio, Simona Salati, Valentina Salvestrini, Lara Rossi, Elena Adinolfi, Michele Baccarani
Homing and engraftment of hematopoietic stem cells (HSCs) to the bone marrow (BM) involve a complex interplay between chemokines, cytokines, and nonpeptide molecules. Extracellular nucleotides and their cognate P2 receptors are emerging as key factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722378218f10d47da0dca72f6ff56f33
https://hdl.handle.net/11380/718843
https://hdl.handle.net/11380/718843