Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karel Souček"'
Autor:
Lucie Jurečková, Veronika Pospíšilová, Petr Vaňhara, Aleš Hampl, Zuzana Holubcová, Vendula Pelková, Daniela Mináriková, Tomáš Bárta, Karel Souček, Dáša Bohačiaková, Volodymyr Porokh
Publikováno v:
Stem Cells and Development. 27:1077-1084
Chromosomal instability evoked by abnormalities in centrosome numbers has been traditionally considered as a hallmark of aberrant, typically cancerous or senescent cells. We have reported previously that pristine human embryonic stem cells (hESC) suf
Autor:
Zbyněk Zdráhal, Olga Vondálová Blanářová, Tomáš Gybeľ, Markéta Pícková, Lucia Kucerova, Ráchel Víchová, Kristína Gömöryová, Tomasz Witold Radaszkiewicz, Karol Kaiser, Vítězslav Bryja, David Potěšil, Tomáš Bárta, Michaela Nosková, Karel Souček, Lucia Demkova, Katarzyna Anna Radaszkiewicz
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplasti
Autor:
Radek Fedr, Mikael Altun, Johan Boström, Diana Mahdessian, Jiřina Medalová, Vítězslav Bryja, Emma Lundberg, Sten Linnarsson, Alena Salašová, Petra Sekyrova, Zuzana Sramkova, Carolyn Marks, Helena A.D. Johard, Karel Souček, Michael Andäng
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0188772 (2017)
PLoS ONE, Vol 12, Iss 12, p e0188772 (2017)
The cell cycle coordinates core functions such as replication and cell division. However, cell-cycle-regulated transcription in the control of non-core functions, such as cell identity maintenance through specific transcription factors (TFs) and sign
Publikováno v:
Cellular Signalling. 22:1734-1744
Chronic inflammation plays an important role in the initiation and progression of various human diseases including benign prostatic hyperplasia or prostate cancer. Here we show that the proinflammatory cytokine interleukin-6 (IL-6) has prosurvival ef
Autor:
János Szöllősi, Viktor Horváth, Jiřina Hofmanová, Alois Kozubík, Ladislav Anděra, Alena Hyršlová Vaculová, György Vereb, Petr Sova, Olga Vondálová Blanářová, Karel Souček, Árpád Szöőr, Belma Skender, Iva Jelínková
Publikováno v:
Carcinogenesis. 32:42-51
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger apoptosis in various cancer cell types. However, many cancer cells are resistant to death receptor-mediated apoptosis. Combination therapy with platinum complexes
Autor:
Aleš Hampl, Zuzana Pernicová, Pavel Krčmář, Alois Kozubík, Andrea Staršíchová, Eva Lincová, Karel Souček, Miroslav Machala
Publikováno v:
Biochemical Pharmacology. 78:561-572
Antitumorigenic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are well established in several types of cancer disease. However, the mechanisms driving these processes are not understood in all details. In our study, we observed significan
Publikováno v:
European Journal of Haematology. 83:35-47
The block of hematopoietic differentiation program in acute myeloid leukemia cells can be overcome by differentiating agent like retinoic acid, but it has several side effects. A study of other differentiation signaling pathways is therefore useful t
Autor:
Jana Slováčková, Jan Šmarda, Eva Ondroušková, Jiřina Procházková, Vendula Pelková, Karel Souček, Petr Beneš
Publikováno v:
bchm. 390:49-58
The Bcl-2 protein is one of the key components of biochemical pathways controlling programmed cell death. The function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significant
Autor:
Jaroslav Turánek, Karel Souček, Jiřina Hofmanová, Alois Kozubík, Jan Vondráček, Alena Hyršlová Vaculová
Publikováno v:
Metal-Based Drugs
The impressive impact of cisplatin on cancer on one side and severe side effects, as well as the development of drug resistance during treatment on the other side, were the factors motivating scientists to design and synthesize new more potent analog