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of 5
pro vyhledávání: '"Joanna Kirkpatrick"'
Autor:
Maximilian Fleischmann, Mike Fischer, Ulf Schnetzke, Colin Fortner, Joanna Kirkpatrick, Florian H. Heidel, Andreas Hochhaus, Sebastian Scholl
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 2992, p 2992 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 2992, p 2992 (2021)
OBJECTIVES: Internal tandem duplications (ITDs) of the Fms-like tyrosine kinase 3 (FLT3) represent the most frequent molecular aberrations in acute myeloid leukemia (AML) and are associated with an inferior prognosis. The pattern of downstream activa
Autor:
Zhao-Qi Wang, Holger Haselmann, Vahid Rahmati, Paulius Grigaravicius, Joanna Kirkpatrick, Mihai Ceanga, Christian Geis, Zhong-Wei Zhou, Murat Kirtay, Katrin Buder, Josefine Sell, Christian Marx, Alessandro Ori
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Ataxia Telangiectasia and Rad3-related (ATR) protein, as a key DNA damage response (DDR) regulator, plays an essential function in response to replication stress and controls cell viability. Hypomorphic mutations of ATR cause the human ATR-Seckel syn
Autor:
Alicia Tapias, David Lázaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Publikováno v:
eLife, 10:e61531
eLife
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bc9b7ac8307bca9080659bf31329cd9d
https://elifesciences.org/articles/61531/figures#content
https://elifesciences.org/articles/61531/figures#content
Autor:
Norman Rahnis, Alexander Dakhovnik, Maria Ermolaeva, Prerana Chaudhari, Joanna Kirkpatrick, Lilia Espada, Ashish Nair, Tetiana Poliezhaieva, Oliver Werz, Asya Martirosyan, Laura Miek, Nadia Döring, Yvonne Schaub, Andreas Koeberle, Alessandro Ori
Publikováno v:
Nature metabolism. 2(11)
Current clinical trials are testing the life-extending benefits of the diabetes drug metformin in healthy individuals without diabetes. However, the metabolic response of a non-diabetic cohort to metformin treatment has not been studied. Here, we sho
Autor:
Carles Recasens-Alvarez, Cyrille Alexandre, Jean-Paul Vincent, Hisashi Nojima, Joanna Kirkpatrick, David J. Huels, Ambrosius P. Snijders
Publikováno v:
Nature cell biology
Nature cell biology, 23(2), 127-135. Nature Publishing Group
Nature cell biology, 23(2), 127-135. Nature Publishing Group
Ribosomes are multicomponent molecular machines that synthesize all of the proteins of living cells. Most of the genes that encode the protein components of ribosomes are therefore essential. A reduction in gene dosage is often viable albeit deleteri