Zobrazeno 1 - 10
of 17
pro vyhledávání: '"James R. Fuchs"'
Autor:
Emma E. Kraus, Nivedita Jena, Chenglong Li, Marissa C. Granitto, Marissa F. Farinas, Amy E. Lovett-Racke, E Y Zhao, Wei Pei, G Perottino, James R. Fuchs, Michael K. Racke, S I Aqel, V Kumari, Yuhong Yang, L Mao
Publikováno v:
Clinical and Experimental Immunology. 196:215-225
Summary Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in the United States in young adults, but current treatments are only partially effective, making it necessary to develop new, innovative therapeutic strate
Autor:
Fengtian He, Chad Allen Highfill, Ling Li, Liang Xu, Jiqin Lian, Xiaoqing Wu, Jiayuh Lin, Min Ji, Rebecca T. Marquez, Wenhua Tang, Ke Li, James R. Fuchs
Publikováno v:
Oncotarget
// Xiaoqing Wu 1, 2, 3 , Wenhua Tang 1, 2 , Rebecca T. Marquez 1 , Ke Li 1 , Chad A. Highfill 1 , Fengtian He 1, 2, 4 , Jiqin Lian 2, 4 , Jiayuh Lin 5 , James R. Fuchs 6 , Min Ji 3 , Ling Li 2, 7 , Liang Xu 1, 2 1 Departments of Molecular Biosciences
Autor:
Mohammad Aminur Rahman, Dong M. Shin, Fadlo R. Khuri, Abedul Haque, Zhuo Georgia Chen, James R. Fuchs, A.R.M. Ruhul Amin
Publikováno v:
Cancer Letters. 363:166-175
Unlike chemotherapy drugs, the safety of natural compounds such as curcumin has been well established. However, the potential use of curcumin in cancer has been compromised by its low bioavailability, limited tissue distribution and rapid biotransfor
Autor:
Jiayuh Lin, Theodore S. Lawrence, Xiaojie Meng, James R. Fuchs, Xiaoqing Wu, Zhi-Nan Chen, Xiaotan T. Qiao, Liang Xu, Diane M. Simeone, David Karnak, Ling Li, Wenhua Tang, Xinbao Hao, Yongmin Li, Rachel Thompson
Publikováno v:
Clinical Cancer Research. 19:6703-6715
Purpose: Signal transducer and activator of transcription 3 (STAT3) plays a critical role in initiation and progression of pancreatic cancer. However, therapeutically targeting STAT3 has failed clinically. We previously identified HAb18G/CD147 as an
Autor:
Jianmin Wu, Christina Schönherr, Ganesh Umapathy, James R. Fuchs, Kristina Ruuth, Barbara Witek, Roger J. Daly, Ruth H. Palmer, Pui-Kai Li, Kamaraj Sattu, Damini Chand, Falko Hochgräfe, Fredrik Hugosson, Bengt Hallberg
Publikováno v:
The Febs Journal
Activation of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase is a key oncogenic mechanism in a growing number of tumor types. In the majority of cases, ALK is activated by fusion with a dimerizing partner protein as a result of chromos
Autor:
Deanna M. Patmore, Edwin Jousma, Jianqiang Wu, David Eaves, Anat Stemmer-Rachamimov, Timothy P. Cripe, Nancy Ratner, Eric B. Schwartz, Kimberly Breving, Ami V. Patel, James R. Fuchs
Publikováno v:
Oncogene. 33:173-180
Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant sig
Autor:
Eric B. Schwartz, Walter J. Jessen, Jianqiang Wu, James R. Fuchs, Yuanshu Zou, Kevin A. T. Silverstein, Jose A. Cancelas, Deanna M. Patmore, Kwangmin Choi, Mi-Ok Kim, Edwin Jousma, Ami V. Patel, David A. Largaespada, Eva Dombi, Gang Huang, Barbara R. Tschida, David E. Levy, Jed J. Kendall, Vincent W. Keng, Robert J. Spinner, Danhua Fan, Nancy Ratner, Anat Stemmer-Rachamimov
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1979-1990 (2016)
SummaryTo identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β-catenin pathway tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4cd23be8f1a14cb8ed8e1e19cb857a
https://europepmc.org/articles/PMC4782770/
https://europepmc.org/articles/PMC4782770/
Autor:
Zugen Zheng, Li Wang, Kang Zou, Eric B. Schwartz, Qianliang Wang, Jun Yan, Jianqiang Wu, James R. Fuchs
Publikováno v:
Molecular Medicine Reports. 12:498-502
Osteosarcoma (OS) is the most common type of malignant bone tumor. Despite aggressive multimodal treatments, including surgical resection, chemotherapy and adjunctive immunotherapies, patients with OS with high-grade malignancy have a poor five-year
Publikováno v:
Biochemical and Biophysical Research Communications. 416:246-251
Persistent activation of Signal Transducers and Activators of Transcription 3 (STAT3) is frequently detected in colon cancer. Increasing evidence suggests the existence of a small population of colon cancer stem or cancer-initiating cells may be resp
Autor:
Li Lin, Pui-Kai Li, Mingxin Zuo, Jiayuh Lin, Brian Hutzen, Michael A. Ihnat, Stephanie Deangelis, Chenglong Li, Bulbul Pandit, Sarah Ball, Elizabeth Foust, Satyendra S. Shenoy, James R. Fuchs, Samuel K. Kulp
Publikováno v:
Cancer Research. 70:2445-2454
The constitutive activation of signal transducer and activator of transcription 3 (STAT3) is frequently detected in most types of human cancer where it plays important roles in survival, drug resistance, angiogenesis, and other functions. Targeting c