Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jae J. Song"'
Autor:
Hye Jin Choi, Soo Jin Choi, Dongxu Kang, Geun-Hyeok Oh, Zhezhu Han, Suwan Ko, Suyeon Je, Jihyun Lee, Jae J. Song, Yeonsoo Joo
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-19 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Transforming growth factor (TGF)-β signaling is increasingly recognized as a key driver in cancer. In progressive cancer tissues, TGF-β promotes tumor formation, and its increased expression often correlates with cancer malignancy. In this study, w
Publikováno v:
Cellular Signalling. 25:1288-1300
Curcumin as an anticancer agent was investigated in regards to its ability to regulate the switching of cancer cells from survival to necrotic cell death. At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylatio
Autor:
Bo K. Sun, Jae J. Song, Jina Kim, Hyo R. Yoon, Joo Hang Kim, So Y. Kim, Dongxu Kang, Sujin Kang
Publikováno v:
Cellular Signalling. 24:1444-1452
The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing li
Publikováno v:
Clinical Cancer Research. 11:7607-7613
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) is mediated through the activation of apoptosis signal–regulating kinase 1 (ASK1) as a
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Cell Biology. 170:61-72
We have previously observed that metabolic oxidative stress–induced death domain–associated protein (Daxx) trafficking is mediated by the ASK1–SEK1–JNK1–HIPK1 signal transduction pathway. The relocalized Daxx from the nucleus to the cytopla
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Biological Chemistry. 280:26845-26855
We have previously observed that glucose deprivation activates the ASK1-MEK-MAPK signal transduction pathway. In the present study, we reveal that two scaffolding proteins, JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK
Autor:
Yong J. Lee, Jae J. Song
Publikováno v:
Journal of Cellular Biochemistry. 89:653-662
Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinical
Publikováno v:
Yonsei Medical Journal
Purpose Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism in the resista
Publikováno v:
Cellular signalling. 25(1)
Previously, we showed that mitogen-activated protein kinase/extracellular signal-related kinase 4 (MEKK4) is responsible for p38 activation and that its activation during tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment also
Publikováno v:
International journal of oncology. 38(1)
We previously observed that TRAIL induces acquired TRAIL resistance coinciding with increased Akt phosphorylation brought about by the Src-PI3K-Akt signaling pathways and mediated by c-Cbl. c-Cbl, a ubiquitously expressed cytoplasmic adaptor protein,