Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Guangxun Meng"'
Autor:
Liping Zhao, Ailing Lu, Qiuhong Guo, Junling Niu, Shuxian Wu, Ke Xu, Guangxun Meng, Mingkuan Chen, Bing Sun
Publikováno v:
Cytokine. 120:115-124
Host innate immune system is critical for combating invading microbes including Influenza A virus (IAV). As an important arm of the innate immunity, the NLRP3 inflammasome has been found essential for protecting host against IAV challenge, while the
Autor:
Lih-Wen Deng, Peipei Zhou, Lulu Liu, Xiaodan Ding, Guangxun Meng, Xinhui Hui, Bin Li, Fajian Hou, Xiujie Yuan, Jin Zhong, Hui Xiao, Xiaoling Wan, Wei Zhang, Yan Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Trithorax group protein MLL5 is an important epigenetic modifier that controls cell cycle progression, chromatin architecture maintenance, and hematopoiesis. However, whether MLL5 has a role in innate antiviral immunity is largely unknown. Here we sh
Autor:
Shanshan Yan, Ronghua Zhang, Qiaoshi Lian, Zhigang Tian, Hongbo Shen, Xiaoyu Sun, Guangxun Meng, Wenlong Jin, Zheng W. Chen, Wangpeng Gu, Xuan Lin, Bing Sun
Publikováno v:
The Journal of Immunology. 200:1016-1026
The nucleic acids of Mycobacterium tuberculosis can be detected by intracellular DNA sensors, such as cyclic GMP-AMP synthase and absent in melanoma 2 (AIM2), which results in the release of type I IFN and the proinflammatory cytokine IL-1β. However
Autor:
Qiuhong Guo, Guiwen Yang, Guangxun Meng, Guang Xue, Xiaomin Yao, Liguo An, Yue Xing, Hua Li, Yan Zhang
Publikováno v:
The Journal of Immunology. 199:1561-1566
NLRP3 inflammasome activiation requires two sequential signals. The priming signal 1 from TLRs or cytokine receptors induces the transcription of NLRP3 and IL-1β, and concomitantly promotes transcription-independent activation of caspase-1. The acti
Autor:
Boyin Qin, Yanling Feng, Xiaonan Ren, Yuqin Yang, Shuxian Wu, Rongrong Ren, Jialin Cai, Zhigang Song, Yunwen Hu, Lixiang Chen, Xiaohui Zhou, Di Tian, Guangxun Meng, Hua Yang, Chunhua Xu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
The avian origin influenza A virus (IAV) H7N9 has caused a considerable number of human infections associated with high rates of death since its emergence in 2013. As a vital component of the host innate immune system, the nucleotide-binding domain l
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-14 (2017)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP3 inflammasome in 5-FU resistance of oral
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Respiratory fungal infection is a severe clinical problem, especially in patients with compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic fungi are major pulmonary fungal pathogens that are able to result in life-threa
Autor:
Guang Xue, Hongbin Wang, Shuxian Wu, Yongfen Xu, Yao Fujia, Ailing Lu, Junling Niu, Jin Zhong, Zheng Li, Mengmeng Cui, Guangxun Meng
Publikováno v:
Antiviral Research. 172:104607
Simeprevir was developed as a small molecular drug targeting the NS3/4A protease of hepatitis C virus (HCV). Unexpectedly, our current work discovered that Simeprevir effectively promoted the transcription of IFN-β and ISG15, inhibited the infection
Autor:
Eric Pearlman, Xin Lin, Hao Zhou, Helen He Zhu, Tiantian Li, Xin-Ming Jia, Xiaoxia Li, Changbin Chen, Yan Zhang, Aiping Zang, Patricia R. Taylor, Yiyuan Fang, Hui Xiao, Guangxun Meng, Fubin Li, Mei Liu, Shixin Ma, Huanjing Shi, Zihou Deng, Xiaoming Zhang, Gen-Sheng Feng, Min Du, Jiangye Chen
Publikováno v:
Nature immunology
Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Ablatio
Autor:
Guangxun Meng, Yufang Shi, Gao Hanchao, Youcun Qian, Yingying Lin, Yikun Yao, Yoichiro Iwakura, Xiaomin Yao, Xinyang Song, Yan Liu, Jingjing Wang, Nan Shen, Shu Zhu
Publikováno v:
Immunity. 40(1):140-152
SummaryAlthough the microbiota has been shown to drive production of interleukin-17A (IL-17A) from T helper 17 cells to promote cell proliferation and tumor growth in colorectal cancer, the molecular mechanisms for microbiota-mediated regulation of t