Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Franziska M. Uhl"'
Autor:
Franziska M. Uhl, Dietmar Pfeifer, Melanie Boerries, Donatella De Feo, Shaima’a Hamarsheh, Heiko Becker, Benedikt S. Saller, Lena Osswald, Claudia Lengerke, Janaki Manoja Vinnakota, Miriam Erlacher, Geoffroy Andrieux, Justus Duyster, Sandra Duquesne, Robert Zeiser, Martina Konantz, Mark E. Cooper, Annette Schmitt-Graeff, Tilman Brummer, Christoph Schürch, Charlotte M. Niemeyer, Nils Venhoff, Olaf Groß, Michael Lübbert, Khalid Shoumariyeh, Burkhard Becher, Susanne Unger, Bruce R. Blazar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Shaima'a, Hamarsheh, Lena, Osswald, Benedikt S, Saller, Susanne, Unger, Donatella, De Feo, Janaki Manoja, Vinnakota, Martina, Konantz, Franziska M, Uhl, Heiko, Becker, Michael, Lübbert, Khalid, Shoumariyeh, Christoph, Schürch, Geoffroy, Andrieux, Nils, Venhoff, Annette, Schmitt-Graeff, Sandra, Duquesne, Dietmar, Pfeifer, Matthew A, Cooper, Claudia, Lengerke, Melanie, Boerries, Justus, Duyster, Charlotte M, Niemeyer, Miriam, Erlacher, Bruce R, Blazar, Burkard, Becher, Olaf, Groß, Tilman, Brummer, Robert, Zeiser
Publikováno v:
Nature Communications
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link b
Autor:
Franziska M. Uhl, Sandra Braun, Lisa C. Schmitt, Robert Zeiser, Björn Schorch, Martin Köhler, Wolfgang W. A. Schamel, Michael Röring, Katharina Heilmann, Sebastian Herzog, Florian Weinberg, Gina J. Fiala, Thorsten Kaltenbacher, Hassan Jumaa, Sophia Ehrenfeld, Natalie Stickel, Tilman Brummer
Publikováno v:
The EMBO journal. 35(2)
Despite being mutated in cancer and RASopathies, the role of the activation segment (AS) has not been addressed for B-Raf signaling in vivo. Here, we generated a conditional knock-in mouse allowing the expression of the B-Raf(AVKA) mutant in which th