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pro vyhledávání: '"Douglas Lauffenburger"'
Publikováno v:
Nature Reviews. Cancer, 22, 157-173
Nature Reviews. Cancer, 22, 3, pp. 157-173
Nature Reviews. Cancer, 22, 3, pp. 157-173
Contains fulltext : 249011.pdf (Publisher’s version ) (Closed access) Resistance to therapeutic treatment and metastatic progression jointly determine a fatal outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied
Publikováno v:
Nature communications. 13(1)
Mammalian cells adapt their functional state in response to external signals in form of ligands that bind receptors on the cell-surface. Mechanistically, this involves signal-processing through a complex network of molecular interactions that govern
Publikováno v:
The Journal of biological chemistry. 278(26)
Endocytic trafficking plays an important role in the regulation of the epidermal growth factor receptor (EGFR) family. Many cell types express multiple EGFR family members (including EGFR, HER2, HER3, and/or HER4) that interact to form an array of ho