Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Raquel Maeso‐Díaz, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, Anna Mae Diehl
Publikováno v:
Aging Cell. 21
Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with crit
Autor:
Tianyi Chen, Jeongeun Hyun, Ali Ahmadi, Hidekazu Tsukamoto, Zhaoli Sun, Kuo Du, Ullas V. Chembazhi, Anna Mae Diehl, Ivan Rusyn, Sushant Bangru, Auinash Kalsotra
Publikováno v:
J Clin Invest
Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature liver cells, why this occurs and how it causes death are unclear. Here
Autor:
Andrea G. Nackley, Wolfgang Liedtke, Anna Mae Diehl, Huiping Ding, Andreas E. Kremer, Johannes Morstein, Ana E. López-Romero, Qian Zeng, Zilong Wang, Ru-Rong Ji, Qiaojuan Zhang, Yong Chen, Xin Zhang, Piotr Milkiewicz, Tony E. Reeves, Sara L. Morales-Lázaro, Jennifer Y. Zhang, Marcin Krawczyk, Tamara Rosenbaum, Mei-Chuan Ko, Frank Lammert, Andrey V. Bortsov, Manal F. Abdelmalek, Michele Yeo, Huanghe Yang, Carlene Moore, Ying-Ai Jin
Publikováno v:
Gastroenterology. 161(1)
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Meth
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 22 (2020)
JCI Insight, Vol 5, Iss 22 (2020)
Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ f
Autor:
Geoffrey I. Scott, Varun Chandrashekaran, Prakash S. Nagarkatti, Diana Kimono, Samir Raychoudhury, Mitzi Nagarkatti, Sutapa Sarkar, Anna Mae Diehl, Firas Alhasson, Ratanesh Seth, Saurabh Chatterjee, Muayad Albadrani, Diptadip Dattaroy
Publikováno v:
Redox Biology, Vol 17, Iss, Pp 1-15 (2018)
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 53:264-278
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of obesity-associated liver diseases and it has become the major cause of cirrhosis in the Western world. The high prevalence of NAFLD-associated advanced liver disease reflects both the
Publikováno v:
Journal of Hepatology. 68:550-562
Liver disease remains a leading cause of mortality worldwide despite recent successes in the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling an epidemic of chronic fatty liver disease for which there are cu
Autor:
Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Varun Chandrashekaran, Jacek Ziolenka, Diptadip Dattaroy, Firas Alhasson, James A. Carson, Ratanesh Seth, Saurabh Chatterjee
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 8-19 (2017)
Redox Biology
Redox Biology
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown. The present study identifies high mobility
Autor:
Sihyung Wang, Jaewook Lee, Hee-Jae Cha, Ji Eun Kim, Youngmi Jung, Eun-Yi Moon, Chanbin Lee, Anna Mae Diehl, Jeongeun Hyun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
SCIENTIFIC REPORTS(7)
Scientific Reports
SCIENTIFIC REPORTS(7)
Scientific Reports
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined in a TB4
Autor:
Jia Li, Anna Mae Diehl, Baojun Zhang, Deepthi Rajagopalan, Sandeep S. Dave, Cassandra Love, Anupama Reddy, Shibo Li, Yuan Zhuang, Young Mi Kim, Sumedha Roy
Publikováno v:
The Journal of Immunology. 198:3136-3148
Inhibitor of DNA binding (Id) proteins, including Id1–4, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins is associated with a broad spectrum of tumors,