Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Autor:
Margaret C. Dunagin, Anil K. Rustgi, Qi Long, E. Paul Wileyto, David A. Frank, Andres J. Klein-Szanto, Varun Sahu, Todd J. Waldron, Sarah R. Walker, Edmund Qiao, Arjun Raj, Adam J. Bass, Kwok-Kin Wong, J. Alan Diehl, Shinya Ohashi, Kiichiro Baba, Qiaosi Tang, Devraj Basu, Zachary T. Giaccone, Eric W. Lin, Monica Soni, Tatiana A. Karakasheva
Publikováno v:
Cancer Research. 78:4957-4970
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential co
Autor:
Timothy Ito, Andres J. Klein-Szanto, Jinfei Xu, Joseph R. Testa, David L. Wiest, Suraj Peri, Eleonora Sementino, Zemin Liu, Yinfei Tan, Kathy Q. Cai, Jianming Pei
Publikováno v:
Oncotarget
// Yinfei Tan 1, * , Eleonora Sementino 1, * , Jinfei Xu 1 , Jianming Pei 1 , Zemin Liu 1 , Timothy K. Ito 1 , Kathy Q. Cai 2 , Suraj Peri 3 , Andres J.P. Klein-Szanto 1, 2 , David L. Wiest 4 , Joseph R. Testa 1 1 Cancer Biology Program, Fox Chase Ca
Autor:
Manti Guha, Prasanna M. Chandramouleeswaran, Andres J. Klein-Szanto, James Garifallou, Clementina Mesaros, Hiroshi Nakagawa, Renata Pellegrino da Silva, Ian A. Blair, Noah Engel, Eishi Noguchi, Joseph A. Baur, Masataka Shimonosono, Hakon Hakonarson, Uma M. Sachdeva, Gordon Ruthel, Michael Gonzalez, Shinya Ohashi, Hisatsugu Maekawa, Kelly A. Whelan, Sarmistha Mukherjee
Publikováno v:
BASE-Bielefeld Academic Search Engine
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239625 (2020)
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While
Autor:
Yuwaraj Kadariya, Andres J. Klein-Szanto, Arti Shukla, Jacqueline Talarchek, Mitchell Cheung, Kathy Q. Cai, Melpo Christofidou-Solomidou, Joseph R. Testa, Craig W. Menges, Ralph A. Pietrofesa, Brooke T. Mossman
Publikováno v:
Cancer Prevention Research. 9:406-414
Exposure to asbestos is causally associated with the development of malignant mesothelioma, a cancer of cells lining the internal body cavities. Malignant mesothelioma is an aggressive cancer resistant to all current therapies. Once inhaled or ingest
Autor:
Dong-Hua Yang, Andrey Gorin, Elizabeth Handorf, Diana Restifo, Gail E. Herman, Erica A. Golemis, Igor Astsaturov, Kunal Manocha, Linara Gabitova, Andres J. Klein-Szanto, Lisa E. Kratz, Kathy Q. Cai, David Cunningham
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1927-1938 (2015)
SummaryMeiosis-activating sterols (MAS) are substrates of SC4MOL and NSDHL in the cholesterol pathway and are important for normal organismal development. Oncogenic transformation by epidermal growth factor receptor (EGFR) or RAS increases the demand
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma
Autor:
Carsten Weishaupt, Björn Kemper, Agatha Stegemann, Mauro Picardo, Andres J. Klein-Szanto, Arianna Mastrofrancesco, Markus Böhm, Dieter Metze
Publikováno v:
Acta Dermato Venereologica. 100:adv00157
Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing prefo
Autor:
Suraj Peri, Frank J. Rauscher, Yuwaraj Kadariya, Richard G. Wilkes, Jinfei Xu, Eleonora Sementino, Joseph R. Testa, Craig W. Menges, Zemin Liu, Andres J. Klein-Szanto, Kathy Q. Cai
Publikováno v:
Journal of cellular physiology. 233(11)
Malignant mesothelioma (MM) is a therapy-resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM are cyclin-dependent kinase inhibitor 2A (CDKN2A), which encodes compone
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes
Autor:
Jacqueline Morris, Terri Schochet, Min-Sun Kim, Anil K. Rustgi, James Eberwine, Jai-Yoon Sul, Andres J. Klein-Szanto
Publikováno v:
Human Pathology. 44:766-776
Summary Elk-1 is a member of the Ets family of transcription factors, which are identified by a conserved Ets DNA-binding domain that mediates transcriptional regulation at Ets sequence--containing promoters. The activation domain of Elk-1 is importa