Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Edward A. Dratz"'
Autor:
Brendan Mumey, Oliver P. Ernst, Anatol Arendt, Paul A. Hargrave, Klaus Peter Hofmann, James B. Burritt, Brian W. Bailey, Algirdas J. Jesaitis, Patrik R. Callis, Edward A. Dratz
Publikováno v:
Protein Science. 12:2453-2475
Rhodopsin is the best-understood member of the large G protein-coupled receptor (GPCR) superfamily. The G-protein amplification cascade is triggered by poorly understood light-induced conformational changes in rhodopsin that are homologous to changes
Publikováno v:
Vision Research. 46(27):4547-4555
Metarhodopsin-II is the light-excited form of rhodopsin that triggers G protein function. Metarhodopsin-II is stabilized when the N-terminus of the carboxyl (340-350) tail peptide of the alpha-subunit of transducin (Gtalpha) is crosslinked to rhodops
Autor:
Chayne L. Piscitelli, Brian W. Bailey, Edward A. Dratz, Thomas E. Angel, Paul A. Hargrave, C. Martin Lawrence
Publikováno v:
The Journal of biological chemistry. 281(10)
Rhodopsin is a G-protein-coupled receptor (GPCR) that is the light detector in the rod cells of the eye. Rhodopsin is the best understood member of the large GPCR superfamily and is the only GPCR for which atomic resolution structures have been deter
Autor:
Peter J. Schatz, Heidi E. Hamm, Edward A. Dratz, Annette Gilchrist, Lida Aris, Carna Meyer, Stephanie Rens-Domiano
Publikováno v:
The Journal of biological chemistry. 276(4)
The retinal receptor rhodopsin undergoes a conformational change upon light excitation to form metarhodopsin II (Meta II), which allows interaction and activation of its cognate G protein, transducin (G(t)). A C-terminal 11-amino acid peptide from tr
Publikováno v:
Experimental Eye Research. 34:339-369
Male Sprague-Dawley rats were maintained, from weaning, on diets deficient either in vitamin E, selenium, chromium and sulfur amino acids (−E−Se−S−Cr), or only in vitamin E and selenium (−E−Se+S+Cr). Control animals (+E+Se+S+Cr) received
Autor:
Paul A. Hargrave, Edward A. Dratz
Publikováno v:
Trends in Biochemical Sciences. 8:128-131
Rhodopsin is the photoreceptor protein of rod cells in the vertebrate retina. Physical studies of the photoreceptor membrane provide a low-resolution structure and show that rhodopsin has a large fraction of its mass embedded in the lipid bilayer. Th
Publikováno v:
Experimental Eye Research. 18:1-12
The molecular organization of the bovine rod outer segment (ROS) disk was investigated with respect to localization of the visual pigment rhodopsin in the membrane. The study made use of preparations of intact disks and ROS fragments. We used the mem
Autor:
S.M. Short, Edward A. Dratz, D.S. Negi, Robert J. Stephens, David W. Thomas, F. J. G. M. Van Kuijk
Publikováno v:
Experimental Eye Research. 47:237-245
Vitamin E is thought to be important for protection of polyunsaturated fatty acids (PUFA) from oxidative damage. A microbiochemical procedure using microdissection and gas chromatography-mass spectrometry was developed to determine vitamin E distribu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 898:81-89
Attempts to optimize the recovery of light-stimulated phosphodiesterase activity following reassociation of the hypotonically extractable proteins derived from retinal rod segments with hypotonically stripped disc membranes lead to the following obse
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 552:281-293
The fatty acid composition of retinal tissues was measured in rats maintained for 26–32 weeks on each of the following diets: a purified basal diet deficient in α-tocopherol and selenium, an identical control diet supplemented with α-tocopherol a