Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Matthew R. Sarkisian"'
Autor:
Matthew R. Sarkisian, Megan M. Le, George Ugartemendia, Lan Hoang-Minh, Tyler S. Smith, Alexander K. Parker, Jason E. Coleman, Eric W. Atkinson, Susan L. Semple-Rowland
Publikováno v:
Experimental Neurology. 282:119-127
Neonatal or early-life seizures (ELS) are often associated with life-long neurophysiological, cognitive and behavioral deficits, but the underlying mechanisms contributing to these deficits remain poorly understood. Newborn, post-migratory cortical n
Autor:
Raddy L, Ramos, Alyssa R, Toia, Daniel M, Pasternack, Timothy P, Dotzler, Joshua A, Cuoco, Anthony W, Esposito, Megan M, Le, Alexander K, Parker, Jeffrey H, Goodman, Matthew R, Sarkisian
Publikováno v:
Neuroscience. 337
Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive
Autor:
Zhao Liu, John C. Neill, Jan Krzysztof Blusztajn, Gregory L. Holmes, Carl E. Stafstrom, Jennifer M. Cermak, Yili Yang, Matthew R. Sarkisian
Publikováno v:
Epilepsy Research. 48:3-13
Prenatal choline supplementation can protect rats against cognitive deficits induced by status epilepticus induced by the cholinergic agent pilocarpine [J. Neurosci. 20 (2000) 1]. In the present day, we have extended this novel finding by investigati
Publikováno v:
Epilepsia. 40:394-400
Summary: Purpose: Disorders in normal central nervous system (CNS) development are often associated with epilepsy. This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat. Methods: Animals (n = 76)
Publikováno v:
Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 1999, 404 (4), pp.537-53
Journal of Comparative Neurology, Wiley, 1999, 404 (4), pp.537-53
International audience; In some children, epilepsy is a catastrophic condition, leading to significant intellectual and behavioral impairment, but little is known about the consequences of recurrent seizures during development. In the present study,
Autor:
Matthew R. Sarkisian, Pushpa Tandon, Zhao Liu, Yili Yang, John C. Neill, Gregory L. Holmes, Carl E. Stafstrom
Publikováno v:
Developmental Brain Research. 95:283-292
The effect of recurrent seizures in developing rats on subsequent long-term behavior was studied. Fifteen day old rats received a convulsant dosage of flurothyl three times daily for five consecutive days. When the rats were fully mature, they underw
Autor:
Gregory L. Holmes, Matthew R. Sarkisian, Zhiqiang Liu, Diosely C. Silveira, P. Tandon, Y. Yang, L.-T Huang, Carl E. Stafstrom
Publikováno v:
Neuroscience. 92(4)
It is well documented that prolonged seizures (status epilepticus) can cause neuronal injury and result in synaptic reorganization in certain brain regions. However, the effect of recurrent, relatively short seizures in young animals on subsequent br
Autor:
Yili Yang, Matthew R. Sarkisian, Pushpa Tandon, Zhao Liu, Gregory L. Holmes, Carl E. Stafstrom
Publikováno v:
Brain research. Developmental brain research. 107(2)
Prolonged seizures in the adult brain causes neuronal loss in the hippocampus and aberrant growth (sprouting) of granule cell axons (mossy fibers) in the supragranular zone of the fascia dentata and stratum infrapyramidale of CA3. There is considerab
Autor:
Zhao Liu, Matthew R. Sarkisian, Pushpa Tandon, Yili Yang, Gregory L. Holmes, Ariyuki Hori, Carl E. Stafstrom
Publikováno v:
Epilepsia. 38(11)
Summary: Purpose: While there is increasing evidence that the adverse effects of prolonged seizures are less pronounced in the immature than in the mature brain, there have been few investigations of the long-term effects of recurrent seizures during
Autor:
Carl E. Stafstrom, Ariyuki Hori, Gregory L. Holmes, Matthew R. Sarkisian, Pushpa Tandon, Yili Yang, Zhao Liu
Publikováno v:
Neuroreport. 8(8)
A glutamate biosensor was used to measure extracellular glutamate concentrations in the hippocampus of mature and immature animals. Significant elevations of extracellular glutamate were observed following seizures induced by either kainic acid or pi