Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Masaki W"'
Autor:
Kazumasa Moriwaki, Masaki Wada, Hiroko Kuwabara, Yusuke Ayani, Tetsuya Terada, Masaaki Higashino, Ryo Kawata, Michio Asahi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Parotid gland cancer (PGC) is a rare malignancy and its molecular characteristics remain poorly understood, which has precluded the development of effective drug therapies. Given the poor prognosis of many human cancers in which tropomyosin
Externí odkaz:
https://doaj.org/article/890df08b97d6404babd1766b535604d3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Individuals with Prader–Willi syndrome (PWS) exhibit complex behavioral characteristics, including hyperphagia, autistic features, and subsequent age-related maladaptive behaviors. While this suggests functional involvements of subcortical
Externí odkaz:
https://doaj.org/article/3e87c116824a4fce9749205617ae9df1
Autor:
Tomomi Miyoshi, Masaki Watanabe
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283432 (2023)
In promoting genomic medicine, genomic literacy, which is the public's ability to acquire and utilize the knowledge and skills related to genetics and genomes, requires urgent improvement. This study determined how the three components of genomic lit
Externí odkaz:
https://doaj.org/article/cb155a803a294e46a113cdc0cbcedb89
Autor:
Saori Sakaue, Etsuro Yamaguchi, Yoshikazu Inoue, Meiko Takahashi, Jun Hirata, Ken Suzuki, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Satoru Miyawaki, Shogo Dofuku, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Kyuto Sonehara, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Masaki Watanabe, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Goto, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Nobuyuki Hizawa, Hideki Mochizuki, Atsushi Kumanogoh, Fumihiko Matsuda, Koh Nakata, Tomomitsu Hirota, Mayumi Tamari, Yukinori Okada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting
Externí odkaz:
https://doaj.org/article/d9a62f084a8e4179916af621aeb86739
Autor:
Masaki Wakai, Ryohei Hayashi, Yoshitaka Ueno, Kana Onishi, Takeshi Takasago, Takuro Uchida, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Serum amyloid A (SAA) is an acute phase inflammatory protein that we previously described as a robust biomarker of colorectal inflammation in patients with ulcerative colitis (UC) in clinical remission. However, what induces SAA expression in UC rema
Externí odkaz:
https://doaj.org/article/d5b49941dce74f608be8c85504cbf8bc
Autor:
Masaki Wakai, Ryohei Hayashi, Yoshitaka Ueno, Kana Onishi, Takeshi Takasago, Takuro Uchida, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0264836 (2022)
Serum amyloid A (SAA) is an acute phase inflammatory protein that we previously described as a robust biomarker of colorectal inflammation in patients with ulcerative colitis (UC) in clinical remission. However, what induces SAA expression in UC rema
Externí odkaz:
https://doaj.org/article/419d0cb336a642ec89259a791c08362b
Autor:
Hajime Abe, Norihiko Takeda, Takayuki Isagawa, Hiroaki Semba, Satoshi Nishimura, Masaki Suimye Morioka, Yu Nakagama, Tatsuyuki Sato, Katsura Soma, Katsuhiro Koyama, Masaki Wake, Manami Katoh, Masataka Asagiri, Michael L. Neugent, Jung-whan Kim, Christian Stockmann, Tomo Yonezawa, Ryo Inuzuka, Yasushi Hirota, Koji Maemura, Takeshi Yamashita, Kinya Otsu, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardia
Externí odkaz:
https://doaj.org/article/71dda70f0fa943e6abde76eae9ef37b9
Autor:
Kenta Nakano, Rieko Yanobu-Takanashi, Yukiko Shimizu, Yuki Takahashi, Koki Hiura, Masaki Watanabe, Hayato Sasaki, Tadashi Okamura, Nobuya Sasaki
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234132 (2020)
Diabetic animal models have made significant contributions to understanding the etiology of diabetes and to the development of new medications. Our research group recently developed a novel diabetic mouse strain, the insulin hyposecretion (ihs)mouse.
Externí odkaz:
https://doaj.org/article/d48e1586b0cc4373b063f039dd973b71
Autor:
Justin Goodwin, Michael L. Neugent, Shin Yup Lee, Joshua H. Choe, Hyunsung Choi, Dana M. R. Jenkins, Robin J. Ruthenborg, Maddox W. Robinson, Ji Yun Jeong, Masaki Wake, Hajime Abe, Norihiko Takeda, Hiroko Endo, Masahiro Inoue, Zhenyu Xuan, Hyuntae Yoo, Min Chen, Jung-Mo Ahn, John D. Minna, Kristi L. Helke, Pankaj K. Singh, David B. Shackelford, Jung-whan Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell ca
Externí odkaz:
https://doaj.org/article/978e7e9cf1334033ac7b7717d1595249
Autor:
Hiroaki Semba, Norihiko Takeda, Takayuki Isagawa, Yuki Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Yoshifumi Yamaguchi, Masayuki Miura, Dana M. R. Jenkins, Hyunsung Choi, Jung-whan Kim, Masataka Asagiri, Andrew S. Cowburn, Hajime Abe, Katsura Soma, Katsuhiro Koyama, Manami Katoh, Keimon Sayama, Nobuhito Goda, Randall S. Johnson, Ichiro Manabe, Ryozo Nagai, Issei Komuro
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while pr
Externí odkaz:
https://doaj.org/article/656cb902beff4390965095a7899b983e