Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Khalid M. El-Say"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2640 (2023)
Rosuvastatin (RSV) is a widely used cholesterol-lowering medication, but its limited bioavailability due to its susceptibility to stomach pH and extensive first-pass metabolism poses a significant challenge. A fast-dissolving film (FDF) formulation o
Externí odkaz:
https://doaj.org/article/4b5be52034934b2499cc18085d08c30c
Autor:
Tarek A. Ahmed, Ehab M. M. Ali, Abdulaziz A. Kalantan, Alshaimaa M. Almehmady, Khalid M. El-Say
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1901 (2023)
6-Mercaptopurine (6-MP) is a chemotherapeutic agent with inadequate efficacy due to its poor aqueous solubility and limited bioavailability. Turmeric oil is a naturally occurring bioactive substance obtained from the rhizomes of Curcuma longa Linn th
Externí odkaz:
https://doaj.org/article/27f8fb4a43c84fc88f253386859fdd6b
Autor:
Mohamed F. Zaky, Mohamed A. Megahed, Taha M. Hammady, Shadeed Gad, Mamdouh Mostafa Ghorab, Khalid M. El-Say
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 80 (2022)
Apixaban (Apx), an oral anticoagulant drug, is a direct factor Xa inhibitor for the prophylaxis against venous thromboembolism. Apx has limited oral bioavailability and poor water solubility. The goal of this study was to improve the formulation of a
Externí odkaz:
https://doaj.org/article/6405b0c884324bf09cbab0b622bee553
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 68 (2022)
Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous solubility. The aim of this study was to develop glimepiride tablets using three different manufacturing techniques, as well as to study the
Externí odkaz:
https://doaj.org/article/ba7d507bc5ea4f76a675cef4339b5236
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1741 (2021)
Critical adverse effects and frequent administration, three times per day, limit the use of flutamide (FLT) as a chemotherapeutic agent in the treatment of prostate cancer. Therefore, our research aimed to develop new cholesterol-based nanovesicles f
Externí odkaz:
https://doaj.org/article/621b646d5c7547c599b4375d12f03a30
Autor:
Tarek A. Ahmed, Raed I. Felimban, Hossam H. Tayeb, Waleed Y. Rizg, Fuad H. Alnadwi, Hanadi A. Alotaibi, Nabil A. Alhakamy, Fathy I. Abd-Allah, Gamal A. Mohamed, Ahmed S. Zidan, Khalid M. El-Say
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1733 (2021)
This work aimed to develop a three-dimensional printed (3DP) tablet containing glimepiride (GLMP) and/or rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes. Curcumin oil was extracted from the dried rhizomes of Curcuma longa a
Externí odkaz:
https://doaj.org/article/2c56a6712a4840928033b1787e0fcba5
Autor:
Tarek A. Ahmed, Khalid M. El-Say, Fathy I. Abd-Allah, Abdelsattar M. Omar, Moustafa E. El-Araby, Yosra A. Muhammad, Piyusha P. Pagare, Yan Zhang, Khadijah A. Mohmmad, Osheiza Abdulmalik, Martin K. Safo
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1148 (2021)
Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Me
Externí odkaz:
https://doaj.org/article/53b06f2a01054c37bbf3132feeae3703
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 739 (2021)
To avoid the first-pass metabolism of avanafil (AVA) and its altered absorption in the presence of food after oral administration, this study aimed to investigate the potential of TPGS-based mixed micelle (MM)-loaded film for transdermal delivery and
Externí odkaz:
https://doaj.org/article/82167653b3df462bb0f37e844dfc1402
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1187 (2020)
The study aimed at developing a liquisolid tablet (LST) containing tadalafil (TDL) and dapoxetine (DPX) with improved bioavailability as a potential therapy for male sexual dysfunction. A mixture of nonvolatile solvents, namely PEG 200 and Labrasol®
Externí odkaz:
https://doaj.org/article/949e2e8bc32c4a4d8f2417824223862c
Publikováno v:
Pharmaceutics, Vol 11, Iss 1, p 11 (2019)
Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing β-cyc
Externí odkaz:
https://doaj.org/article/c0d9d49b2e3548a5996b2a36bd236eb7