Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jorge Cruz-Reyes, Joshua Meehan, Karissa Hughes, Pawan K. Doharey, Shelly Gulati, Vikas Kumar, Mary Grace Martinez, Blaine H. M. Mooers
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
Uridylate insertion/deletion RNA editing inTrypanosoma bruceiis a complex system that is not found in humans, so there is interest in targeting this system for drug development. This system uses hundreds of small non-coding guide RNAs (gRNAs) to modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86526f60b24f7c8ab3a3e12703e89126
https://doi.org/10.1101/524702
https://doi.org/10.1101/524702
Autor:
Jorge Cruz-Reyes, Pawan K. Doharey, Vikas Kumar, Luenn Chaparro, Joshua Meehan, Blaine H. M. Mooers
Publikováno v:
RNA Metabolism in Mitochondria ISBN: 9783319781891
RNA metabolism in the single mitochondrion of trypanosomes and related kinetoplastid protozoa exhibits a unique posttranscriptional maturation of mRNAs by specific U insertion/deletion RNA editing that creates protein-coding sequences in 12 mRNA targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1241ac0c6ae994ca5257f7fe1719267
https://doi.org/10.1007/978-3-319-78190-7_5
https://doi.org/10.1007/978-3-319-78190-7_5
Autor:
Richard P. Metz, Bhaskara R. Madina, Blaine H. M. Mooers, Jorge Cruz-Reyes, Ralf Bundschuh, Vikas Kumar
Publikováno v:
RNA. 20:1142-1152
Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3′-to-5′ in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms.
Autor:
Bhaskara R. Madina, Michael Kinter, Kevin Ro, Alfredo J. Hernandez, Belinda Willard, James A. Wohlschlegel, Jorge Cruz-Reyes
Publikováno v:
Journal of Biological Chemistry. 285:1220-1228
Regulation of gene expression in kinetoplastid mitochondria is largely post-transcriptional and involves the orchestration of polycistronic RNA processing, 3′-terminal maturation, RNA editing, turnover, and translation; however, these processes rem
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123441 (2015)
PLoS ONE
PLoS ONE
Adaptation and survival of Trypanosoma brucei requires editing of mitochondrial mRNA by uridylate (U) insertion and deletion. Hundreds of small guide RNAs (gRNAs) direct the mRNA editing at over 3,000 sites. RNA editing is controlled during the life
Publikováno v:
The EMBO Journal. 16:4069-4081
Kinetoplastid mitochondrial RNA editing, the insertion and deletion of U residues, is catalyzed by sequential cleavage, U addition or removal, and ligation reactions and is directed by complementary guide RNAs. We have purified a approximately 20S en