Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jae J. Song"'
Autor:
Hye Jin Choi, Soo Jin Choi, Dongxu Kang, Geun-Hyeok Oh, Zhezhu Han, Suwan Ko, Suyeon Je, Jihyun Lee, Jae J. Song, Yeonsoo Joo
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-19 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Transforming growth factor (TGF)-β signaling is increasingly recognized as a key driver in cancer. In progressive cancer tissues, TGF-β promotes tumor formation, and its increased expression often correlates with cancer malignancy. In this study, w
Publikováno v:
Apoptosis. 21:351-364
In this study, we demonstrated that survivin downregulation with TRAIL expression greatly enhanced the cytotoxic death of pancreatic cancer cells after gemcitabine treatment. Using real-time RT-PCR, we analyzed five survivin shRNAs to identify the be
Publikováno v:
Cancer Gene Therapy. 20:82-87
We previously demonstrated that the downregulation of Casitas B-lineage lymphoma (c-Cbl) can sensitize tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in two different ways. One way is to block the rapid degradation
Autor:
Bo K. Sun, Jae J. Song, Jina Kim, Hyo R. Yoon, Joo Hang Kim, So Y. Kim, Dongxu Kang, Sujin Kang
Publikováno v:
Cellular Signalling. 24:1444-1452
The combination of curcumin and TRAIL and their role in enhancing apoptotic cell death has been reported by many studies. However, the exact molecular mechanism of apoptosis mediated by curcumin and tumor necrosis factor-related apoptosis-inducing li
Autor:
Marco A. Alcala, Yong Tae Kwon, Miroslaw J. Szczepanski, Joo Hang Kim, So Young Kim, Jee Young An, David L. Bartlett, Yong J. Lee, Jae J. Song
Publikováno v:
Cellular Signalling. 22:553-563
We previously reported two modes of development of acquired TRAIL resistance: early phase and late phase [1]. In these studies, we observed that greater Akt activity and the expression of Bcl-xL were related mainly to the late phase of acquired TRAIL
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Cellular Signalling. 20:892-906
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis through caspase activation in a number of cancer cell lines while displaying minimal or no toxicity on normal cells, suggesting that this protein may h
Publikováno v:
Cellular signalling. 27(6)
We previously showed that an increase of cellular Bcl-xL mediates acquired resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and knockdown of Bcl-xL expression greatly sensitized TRAIL-induced cytotoxicity. Here, we show t
Publikováno v:
Yonsei Medical Journal
Purpose Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism in the resista
Publikováno v:
Cancer gene therapy. 20(2)
Tumor cells secrete a variety of cytokines to outgrow and evade host immune surveillance. In this context, transforming growth factor-β1 (TGF-β1) is an extremely interesting cytokine because it has biphasic effects in cancer cells and normal cells.
Publikováno v:
Cellular signalling. 25(1)
Previously, we showed that mitogen-activated protein kinase/extracellular signal-related kinase 4 (MEKK4) is responsible for p38 activation and that its activation during tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment also