Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan Hall"'
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
MicroRNAs constitute a class of endogenous, non‐coding RNAs that influence various processes within the cell. By base‐pairing to partially‐complementary sites located in the 3’ untranslated region of target messenger RNAs, microRNAs participa
Autor:
Malgorzata M, Duszczyk, Harry, Wischnewski, Tamara, Kazeeva, Rajika, Arora, Fionna E, Loughlin, Christine, von Schroetter, Ugo, Pradère, Jonathan, Hall, Constance, Ciaudo, Frédéric H-T, Allain
Publikováno v:
Nature communications. 13(1)
Dead End (DND1) is an RNA-binding protein essential for germline development through its role in post-transcriptional gene regulation. The molecular mechanisms behind selection and regulation of its targets are unknown. Here, we present the solution
Publikováno v:
Febs Letters
Identifying the targetome of a microRNA is key for understanding its functions. Cross-linking and immunoprecipitation (CLIP) methods capture native miRNA-mRNA interactions in cells. Some of these methods yield small amounts of chimeric miRNA-mRNA seq
Autor:
Anneke Brümmer, Jonathan Hall, Nitish Mittal, André P. Gerber, Panagiota Tsikrika, Shivendra Kishore, Jochen Imig, Boris Guennewig, Mihaela Zavolan, Andreas Brunschweiger
Publikováno v:
Nature Chemical Biology
Identifying the interaction partners of noncoding RNAs is essential for elucidating their functions. We have developed an approach, termed microRNA crosslinking and immunoprecipitation (miR-CLIP), using pre-miRNAs modified with psoralen and biotin to
Autor:
Helen L. Lightfoot, Jonathan Hall, Daniel Schümperli, François Halloy, Meiling Li, Christian Berk, Anna L. Malinowska, Alok Behera
Publikováno v:
Chemical communications (Cambridge, England). 53(3)
Stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate (PS-MOE) oligonucleotides were synthesized from new chiral oxazaphospholidine-containing nucleosides. Thermal stability studies showed that the incorporation of Rp-PS linkages increased R
Autor:
Sara Nasso, Mihaela Zavolan, Jonathan Hall, Sandra Goetze, Michael O. Hengartner, Martin Keller, Erich Brunner, Sérgio Morgado Pinto, Anneke Brümmer, Marko Jovanovic, Helen Louise Lightfoot, Ruedi Aebersold, Yibo Wu, Deni Subasic, Jochen Imig
In animals, microRNAs frequently form families with related sequences. The functional relevance of miRNA families and the relative contribution of family members to target repression have remained, however, largely unexplored. Here, we used the Caeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba1a17e29fcc75932aa1303552443a4
https://europepmc.org/articles/PMC4617964/
https://europepmc.org/articles/PMC4617964/
Autor:
George F. Babcock, Rosa Bernardi, Arti Neb-Gulati, Stefano Fumagalli, Alessandro Di Cara, Jonathan Hall, George Thomas, Pier Paolo Pandolfi, Francois Natt, Sandy Schwemberger
Publikováno v:
Nature Cell Biology. 11:501-508
Impaired ribosome biogenesis is attributed to nucleolar disruption and diffusion of a subset of 60S ribosomal proteins, particularly ribosomal protein (rp)L11, into the nucleoplasm, where they inhibit MDM2, leading to p53 induction and cell-cycle arr
Autor:
Gabriele Dorn, Glen Wotherspoon, Jonathan Hall, Stuart Bevan, Sadhana Patel, Samir Abdel'Al, Pam Ganju, Francois Natt, Janet Winter, Alyson Fox, L. H. Eunson, William Leonard Wishart, Sarah Moffatt, Jane Barclay
Publikováno v:
The Journal of Neuroscience. 22:8139-8147
The excitation of nociceptive sensory neurons by ATP released in injured tissue is believed to be mediated partly by P2X(3)receptors. Although an analysis of P2X(3) knock-out mice has revealed some deficits in nociceptive signaling, detailed analysis
Autor:
Jonathan Hall, Helen L. Lightfoot
Publikováno v:
Nucleic Acids Research, 42 (18)
Nucleic Acids Research
Nucleic Acids Research
Recent progress with techniques for monitoring RNA structure in cells such as ‘DMS-Seq’ and ‘Structure-Seq’ suggests that a new era of RNA structure-function exploration is on the horizon. This will also include systematic investigation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657aaca47267fa63811fb6787e5e857c
Autor:
Bernhard Odermatt, Siân H. Leech, Bettina Baumann, A. Paula Simões-Wüst, Robert A. Olie, Uwe Zangemeister-Wittke, Jonathan Hall, Oliver Gautschi, Annemarie Ziegler, Rolf A. Stahel, Stefan Tschopp
Publikováno v:
JNCI Journal of the National Cancer Institute. 93:463-471
Background: Increased expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL is involved in the development and progression of many tumors. We recently reported that the bcl-2/bcl-xL-bispecific antisense oligonucleotide 4625 induces apoptosis in