Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Daniel T. Meehan"'
Autor:
Grady Phillips, Michael Anne Gratton, Duane Delimont, Deidre A. MacKenna, Gretchen Bain, Dominic Cosgrove, Daniel T. Meehan, Brianna Dufek, Michael Hartnett, Gina Samuelson
Publikováno v:
Kidney Int
Lysyl oxidase like-2 (LOXL2) is an amine oxidase with both intracellular and extracellular functions. Extracellularly, LOXL2 promotes collagen and elastin crosslinking, whereas intracellularly, LOXL2 has been reported to modify histone H3, stabilize
Autor:
George E. Lees, Rakesh K. Singh, Ryochi Nemori, Kathyrn D. Rodgers, Velidi H. Rao, Dominic Cosgrove, Clifford E. Kashtan, Gautam Bhattacharya, Brian R. Berridge, Daniel T. Meehan
Publikováno v:
Kidney International. 63(5):1736-1748
Increased expression of MMP-2, MMP-9 (type IV collagenases/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS). Background Alport syndrome is a group of genetic disorders resulting from mutations in either the α3(IV), α4(IV) or α5(
Autor:
Raghuram Kalluri, Kathyrn D. Rodgers, Robinlyn Sayers, Dominic Cosgrove, Daniel T. Meehan, Charles F. Shield
Publikováno v:
Kidney International. 56:1662-1673
Role for transforming growth factor-β1 in Alport renal disease progression. Background Alport syndrome results from mutations in either the α3(IV), α4(IV), or α5(IV) collagen genes. The disease is characterized by a progressive glomerulonephritis
Autor:
Dominic Cosgrove, William J. Hunter, James A. Grunkemeyer, Daniel T. Meehan, Jody M. Kornak, Robinlyn Sayers, Gina Samuelson
Publikováno v:
Genes & Development. 10:2981-2992
A mouse model for the autosomal form of Alport syndrome was produced. These mice develop a progressive glomerulonephritis with microhematuria and proteinuria, consistent with the human disease. End-stage renal disease develops at approximately 14 wee
Autor:
Duane Delimont, Velidi H. Rao, Dominic Cosgrove, Steven C. Sansom, Marisa Zallocchi, Linda Cheung, J. David Holzclaw, Daniel T. Meehan
Publikováno v:
Kidney international. 76(9)
Alport glomerular disease is associated with dysregulation of pro-inflammatory cytokines and matrix metalloproteinases, promoting progressive glomerulonephritis. Changes in composition and structure of Alport GBM resulting from mutations in type IV c
Autor:
Michael Anne Gratton, Christie A. Rothermund-Franklin, Charles Askew, Suneetha Garige, Daniel T. Meehan, Duane Delimont, Marisa Zallocchi, Dominic Cosgrove
Publikováno v:
Hearing research. 255(1-2)
The Usher syndrome 3A (CLRN1) gene encodes clarin-1, which is a member of the tetraspanin family of transmembrane proteins. Although identified more than 6 years ago, little is known about its localization or function in the eye and ear. We developed
Publikováno v:
The American journal of pathology. 166(5)
Alport syndrome results from mutations in genes encoding collagen alpha3(IV), alpha4(IV), or alpha5(IV) and is characterized by progressive glomerular disease associated with a high-frequency sensorineural hearing loss. Earlier studies of a gene knoc
Publikováno v:
Hearing research. 163(1-2)
The interaction of extracellular matrix and receptors plays a role in tissue homeostasis. The thickened strial capillary basement membrane (SCBM) reported in animal models of presbycusis and Alport's syndrome might be secondary to elevated synthesis