Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Bart Staels"'
Autor:
Emmanuel Bouchaert, Patrick Duriez, Gérald Luc, Zouher Majd, Audrey Helleboid, Didier Cussac, Régis Bordet, Dean W. Hum, Emilie Lauressergues, Françoise Martin, Bart Staels
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 383:423-436
Weight gain and metabolic disturbances, such as dyslipidemia and hyperglycaemia, are common side effects of most antipsychotic drugs, including risperidone. The aim of this study was to investigate the effects of chronic treatment with risperidone on
Autor:
Yoav Sin-Malia, Juergen Eckel, Yael Riahi, Guy Cohen, Bart Staels, Evgenia Alpert, Arie Gruzman, Michel Guichardant, Shlomo Sasson
Publikováno v:
Diabetes
OBJECTIVE Vascular endothelial cells (VECs) downregulate their rate of glucose uptake in response to hyperglycemia by decreasing the expression of their typical glucose transporter GLUT-1. Hitherto, we discovered critical roles for the protein calret
Autor:
Céline Cudejko, Eric Bauge, Jean-Pierre Salles, Réjane Paumelle, Thierry Touvier, Bernard Bailleul, Olivier Briand, Bart Staels, Sandrine Caron, Francoise Conte-Auriol, Yves Rouillé
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2009, 119 (12), pp.3830-8. ⟨10.1172/JCI34997⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2009, 119 (12), pp.3830-8. ⟨10.1172/JCI34997⟩
International audience; Growth hormone (GH) is a major metabolic regulator that functions by stimulating lipolysis, preventing protein catabolism, and decreasing insulin-dependent glucose disposal. Modulation of hepatic sensitivity to GH and the down
Autor:
Gérard Torpier, Emmanuelle Jeanpierre, Eric Van Belle, Marianne Delestre, Francis Juthier, Bruno Quesnel, Richard Azzaoui, Bart Staels, Christophe Zawadzki, Nicolas Chatelain, Delphine Corseaux, Joke Breyne, Sophie Susen, Brigitte Jude
Publikováno v:
Atherosclerosis. 204:e4-e14
The tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type serine-protease inhibitor which is expressed in atherosclerotic plaques. Epigenetic regulation of the TFPI-2 gene, through methylation of CpG islands, has been advocated in cancer. We hy
Autor:
Mouaadh Abdelkarim, Brigitte Bois-Joyeux, Bart Staels, Christian Duhem, Saara Laitinen, Hélène Duez, Jean-Louis Danan, Prashant S. Patole
Publikováno v:
FEBS Letters. 583:2031-2036
Here we show that gene expression of the nuclear receptor RORalpha is induced during adipogenesis, with RORalpha4 being the most abundantly expressed isoform in human and murine adipose tissue. Over-expression of RORalpha4 in 3T3-L1 cells impairs adi
Autor:
Vincent Laudet, Gérard Benoit, Ingrid Masse, Bart Staels, Juliette Rambaud, Gérard Triqueneaux
Publikováno v:
Mol Endocrinol
Mol Endocrinol, 2009, 23 (5), pp.630-9. ⟨10.1210/me.2008-0395⟩
Mol Endocrinol, 2009, 23 (5), pp.630-9. ⟨10.1210/me.2008-0395⟩
International audience; Circadian rhythms are observed in nearly all aspects of physiology and behavior. In mammals, such biological rhythms are supported by a complex network of self-sustained transcriptional loops and posttranslational modification
Autor:
Coralie Fontaine, Bruno Lefebvre, Christian Duhem, Elena Rigamonti, Philippe Lefebvre, Nikolaus Marx, Giulia Chinetti-Gbaguidi, Bart Staels
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:932-939
Objective—Macrophages play a central role in the immune response against infectious organisms. Once activated, macrophages secrete proinflammatory cytokines and chemokines. Interleukin (IL)-8 and related CXC chemokines play a role in the recruitmen
Publikováno v:
Journal of Molecular Endocrinology. 39:29-44
Retinoid-related orphan receptor gamma (ROR gamma) is an orphan nuclear hormone receptor (NR) that is preferentially expressed in skeletal muscle and several other tissues, including pancreas, thymus, prostate, liver and testis. Surprisingly, the spe
Autor:
Kadiombo Bantubungi, Yasmine Sebti, Emilie Dorchies, Emmanuelle Vallez, Nathalie Hennuyer, Olivier Briand, Sophie Lestavel, Alessia Perino, Anne Tailleux, Philippe Marchetti, Jerome Kluza, Philippe Lefebvre, Robert Caiazzo, Sama I. Sayin, Cheryl A. Brighton, Sarah Ducastel, Véronique Touche, Fiona M. Gribble, Hélène Dehondt, Bart Staels, Mohamed-Sami Trabelsi, Frank Reimann, Valeria Spinelli, Janne Prawitt, Fredrik Bäckhed, Kristina Schoonjans, Mehdi Daoudi, François Pattou, Gregory Baud, Sandrine Caron
Publikováno v:
Nature communications
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces g
Autor:
Olivier Barbier, Jocelyn Trottier, Julie Bélanger, Jessica A. Bonzo, Bart Staels, Kathy Senekeo-Effenberger, Mélanie Verreault, Jenny Kaeding, Patrick Caron, Robert H. Tukey
Publikováno v:
Hepatology. 44:368-378
Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP-glucuronosyltransferase (UGT) family. Among UGT enzymes, UGT1A3 is considered the major human enzyme for the hepatic C24-glucuronidation of t