Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alfredo Castello"'
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Publikováno v:
Seminars in Cell & Developmental Biology
Highlights • Proteomic studies have uncovered more than a thousand cellular proteins that are present in the particles of RNA viruses. • Strikingly, nearly four hundred of these are RNA-binding proteins (RBPs). • Several virion-incorporated RBP
Autor:
Cornelia, Kilchert, Tea, Kecman, Emily, Priest, Svenja, Hester, Ebru, Aydin, Krzysztof, Kus, Oliver, Rossbach, Alfredo, Castello, Shabaz, Mohammed, Lidia, Vasiljeva
Publikováno v:
Genome Res
Large RNA-binding complexes play a central role in gene expression and orchestrate production, function, and turnover of mRNAs. The accuracy and dynamics of RNA–protein interactions within these molecular machines are essential for their function a
Autor:
Rastislav Horos, Jeroen Krijgsveld, Bernd Fischer, Matthias W. Hentze, Anne-Marie Alleaume, Aino I. Järvelin, Alfredo Castello, Tomaz Curk, Christian K. Frese, Sophia Foehr
This protocol is an extension to: Nat. Protoc. 8, 491-500 (2013); doi:10.1038/nprot.2013.020; published online 14 February 2013RBDmap is a method for identifying, in a proteome-wide manner, the regions of RNA-binding proteins (RBPs) engaged in native
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439744352e2776e3c09ad2fa219ef3d5
https://eprints.gla.ac.uk/222047/1/222047.pdf
https://eprints.gla.ac.uk/222047/1/222047.pdf
Autor:
Matthias W. Hentze, Alfredo Castello, Elena G. Sánchez, Ana Quintas, Maria L. Nogal, Yolanda Revilla, Daniel Pérez-Núñez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Virology
instname
Journal of Virology
African swine fever virus (ASFV) infection is characterized by a progressive decrease in cellular protein synthesis with a concomitant increase in viral protein synthesis, though the mechanism by which the virus achieves this is still unknown. Decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb3b134cf51d88732630badbe19a4c2
https://eprints.gla.ac.uk/221915/1/221915.pdf
https://eprints.gla.ac.uk/221915/1/221915.pdf
Publikováno v:
RNA. 20:721-731
RNA-binding proteins (RBPs) control RNA fate from synthesis to decay. Since their cellular expression levels frequently do not reflect their in vivo activity, methods are needed to assess the steady state RNA-binding activity of RBPs as well as their
Publikováno v:
Trends in Genetics
RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function underlie a broad spectrum of human pathologies. We focus here on two recent studies that uncovered the in vivo mRNA interactomes of human cells, jointly implic
Autor:
Stefan Leicht, Hao Yang, Matthias W. Hentze, Thomas Preiss, Chikako Ragan, Yalin Liao, Alfredo Castello, Jeroen Krijgsveld, Bernd Fischer, Eloisa Pagler, Christian K. Frese, Sophia Foehr, Sebastian Kurscheid
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1456-1469 (2016)
Europe PubMed Central
Cell Reports
Europe PubMed Central
Cell Reports
Summary RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL-1 cells by jointly employing two in vivo proteomic methods, mRNA in
Publikováno v:
Journal of Molecular Biology. 394:506-521
Cytolytic viruses abrogate host protein synthesis to maximize the translation of their own mRNAs. In this study, we analyzed the eukaryotic initiation factor (eIF) 4G requirement for translation of vesicular stomatitis virus (VSV) and vaccinia virus
RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Cytopathic viruses have developed successful strategies to block or, at least, to attenuate host interference with their replication. Here, we have analyzed the effects of poliovirus 2A protease on RNA nuclear export. 2A protease interferes with traf