Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jorge Cruz-Reyes, Andrew Hillhouse, Daniel Camilo Osorio Hurtado, Alasdair Ivens, Xiuren Zhang, Pawan K. Doharey, Joshua Meehan, Zachary T Goodall, Achim Schnaufer, Vikas Kumar, James J. Cai
Publikováno v:
Kumar, V, Ivens, A, Goodall, Z, Meehan, J, Doharey, P K, Hillhouse, A, Hurtado, D O, Cai, J J, Zhang, X, Schnaufer, A & Cruz-Reyes, J 2020, ' Site-specific and mRNA-specific control of accurate mRNA editing by a helicase complex in trypanosomes ', RNA, vol. 26, no. 10, rna.076513.120 . https://doi.org/10.1261/rna.076513.120
RNA
RNA
Trypanosome U-insertion/deletion RNA editing in mitochondrial mRNAs involves guide RNAs (gRNAs) and the auxiliary RNA editing substrate binding complex (RESC) and RNA editing helicase 2 complex (REH2C). RESC and REH2C stably copurify with editing mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544f1407045fc8df53ea00d87dc63e7
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
Autor:
Richard P. Metz, Bhaskara R. Madina, Blaine H. M. Mooers, Jorge Cruz-Reyes, Ralf Bundschuh, Vikas Kumar
Publikováno v:
RNA. 20:1142-1152
Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3′-to-5′ in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms.
Autor:
James A. Wohlschlegel, Gokulan Kuppan, Sing-Hoi Sze, Yu-He Liang, Xinhua Ji, Bhaskara R. Madina, Laurie K. Read, Kurtis M. Downey, Ajay A. Vashisht, James C. Sacchettini, Jorge Cruz-Reyes
Publikováno v:
RNA. 17:1821-1830
The mitochondrial genome of kinetoplastids, including species of Trypanosoma and Leishmania, is an unprecedented DNA structure of catenated maxicircles and minicircles. Maxicircles represent the typical mitochondrial genome encoding components of the
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123441 (2015)
PLoS ONE
PLoS ONE
Adaptation and survival of Trypanosoma brucei requires editing of mitochondrial mRNA by uridylate (U) insertion and deletion. Hundreds of small guide RNAs (gRNAs) direct the mRNA editing at over 3,000 sites. RNA editing is controlled during the life
Publikováno v:
Molecular and Cellular Biology. 21:884-892
Trypanosome RNA editing is a massive processing of mRNA by U deletion and U insertion, directed by trans-acting guide RNAs (gRNAs). A U deletion cycle and a U insertion cycle have been reproduced in vitro using synthetic ATPase (A6) pre-mRNA and gRNA
Autor:
Barbara Sollner-Webb, Jorge Cruz-Reyes
Publikováno v:
Proceedings of the National Academy of Sciences. 93:8901-8906
We have studied the mechanism of accurate in vitro RNA editing of Trypanosoma brucei ATPase 6 mRNA, using four mRNA-guide RNA (gRNA) pairs that specify deletion of 2, 3, or 4 U residues at editing site 1 and mitochondrial extract. This extract not on
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12235 (2010)
PLoS ONE, Vol 5, Iss 8, p e12235 (2010)
Mitochondrial mRNA editing in Trypanosoma brucei requires the specific interaction of a guide RNA with its cognate mRNA. Hundreds of gRNAs are involved in the editing process, each needing to target their specific editing domain within the target mes
Autor:
Alfredo, Hernandez, Bhaskara Reddy, Madina, Kevin, Ro, James A, Wohlschlegel, Belinda, Willard, Mike T, Kinter, Jorge, Cruz-Reyes
Publikováno v:
The Journal of biological chemistry. 285(2)
Regulation of gene expression in kinetoplastid mitochondria is largely post-transcriptional and involves the orchestration of polycistronic RNA processing, 3′-terminal maturation, RNA editing, turnover, and translation; however, these processes rem
RNA editing in Trypanosoma brucei is posttranscriptional uridylate removal/addition, generally at vast numbers of pre-mRNA sites, but to date, only single editing cycles have been examined in vitro. We here demonstrate achieving sequential cycles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40eaf976fa33a540f47bfc367845d137
https://europepmc.org/articles/PMC2268434/
https://europepmc.org/articles/PMC2268434/
Autor:
Alfredo J. Hernandez, Kenneth Stuart, Catherine Cifuentes-Rojas, Aswini K. Panigrahi, Jorge Cruz-Reyes, Anastasia Sacharidou
Publikováno v:
Journal of molecular biology. 381(1)
U-insertion/deletion RNA editing in the single mitochondrion of kinetoplastids, an ancient lineage of eukaryotes, is a unique mRNA maturation process needed for translation. Multisubunit editing complexes recognize many pre-edited mRNA sites and modi