Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Robert Landick"'
Autor:
Beth A. Shen, Robert Landick
Publikováno v:
J Mol Biol
Decades of research have probed the interplay between chromatin (genomic DNA associated with proteins and RNAs) and transcription by RNA polymerase (RNAP) in all domains of life. In bacteria, chromatin is compacted into a membrane-free region known a
Autor:
Yu Bao, Robert Landick
Publikováno v:
Proc Natl Acad Sci U S A
The catalytic trigger loop (TL) in RNA polymerase (RNAP) alternates between unstructured and helical hairpin conformations to admit and then contact the NTP substrate during transcription. In many bacterial lineages, the TL is interrupted by insertio
Autor:
Andreas Martin, Michael R. Lawson, Michael J. Bellecourt, Klaus Schulten, Irina Artsimovitch, James M. Berger, Wen Ma, Robert Landick
Publikováno v:
Molecular cell. 71(6)
NusG/Spt5 proteins are the only transcription factors utilized by all cellular organisms. In enterobacteria, NusG antagonizes the transcription termination activity of Rho, a hexameric helicase, during the transcription of ribosomal and actively-tran
Autor:
Jin Young Kang, Michael J. Bellecourt, Seth A. Darst, Rachel A. Mooney, Tatiana V. Mishanina, Robert Landick
Publikováno v:
Molecular cell. 69(5)
Sequence-specific pausing by RNA polymerase (RNAP) during transcription plays crucial and diverse roles in gene expression. In bacteria, RNA structures are thought to fold within the RNA exit channel of the RNAP and can increase pause lifetimes signi
Publikováno v:
Proceedings of the National Academy of Sciences. 114
In bacteria, intrinsic termination signals cause disassembly of the highly stable elongating transcription complex (EC) over windows of two to three nucleotides after kilobases of RNA synthesis. Intrinsic termination is caused by the formation of a n
Autor:
Boris Fürtig, Rachel A. Mooney, Beatrix Suess, Hannah Steinert, Christina Helmling, Fabian Hiller, Martin Rudolph, Janina Buck, Anna Wacker, Florian Sochor, Harald Schwalbe, Jonas Noeske, Robert Landick, Jens Wöhnert, Steffen Grimm, Sara Keyhani, Heiko Keller
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refol
Publikováno v:
Science
Coupling transcription and translation In bacteria, the transcription of DNA into mRNA by RNA polymerase is coupled to the translation of that mRNA into protein by the ribosome. How this coupling is achieved has been unclear. Kohler et al. show that
Publikováno v:
Annual review of biochemistry. 85
Transcript termination is essential for accurate gene expression and the removal of RNA polymerase (RNAP) at the ends of transcription units. In bacteria, two mechanisms are responsible for proper transcript termination: intrinsic termination and Rho
Publikováno v:
Journal of Molecular Biology. 401:708-725
NusA is a core regulator of transcript elongation that is well conserved in bacteria and archaea. NusA interacts with elongating complexes and the nascent RNA transcript in ways that stimulate pausing and termination but can be switched to anti-pausi
Publikováno v:
The EMBO Journal. 28:112-122
Elongation factors NusG and RfaH evolved from a common ancestor and utilize the same binding site on RNA polymerase (RNAP) to modulate transcription. However, although NusG associates with RNAP transcribing most Escherichia coli genes, RfaH regulates