Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Thomas Tuschl"'
Autor:
Stanley Fields, Marvin Wickens, Gabor Banyai, Daniel Melamed, Wei Zhou, Junyue Cao, Thomas Tuschl, Cindy Meyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The ability to design a protein to bind specifically to a target RNA enables numerous applications, with the modular architecture of the PUF domain lending itself to new RNA-binding specificities. For each repeat of the Pumilio-1 PUF domain, we gener
Autor:
Camila R. R. Pão, Thomas Tuschl, Aitor Garzia, Lucas Villas Bôas Hoelz, Felipe Betoni Saraiva, Suelen da Silva Gomes Dias, Dumith Chequer Bou-Habib, Frederico Silva Castelo Branco, Wei Xie, Jingyue Ju, Chuanjuan Tao, Vinicius Cardoso Soares, André C. Ferreira, Stevens K. Rehen, Jairo R. Temerozo, Caroline S. de Freitas, Carine dos Santos da Silva, Carolina Q. Sacramento, Marília Zaluar P. Guimarães, Andrew Owen, Thiago Moreno L. Souza, Patrícia T. Bozza, Xuanting Wang, Nubia Boechat, Mayara Mattos, Rajith K. R. Rajoli, Dinshaw J. Patel, Steffen Jockusch, Marcelo Alves Ferreira, Fernando A. Bozza, Natalia Fintelman-Rodrigues, Gabriela Vitória, Livia Goto-Silva, Tácio Vinício Amorim Fernandes, Aline de Paula Dias Da Silva, Mônica M. Bastos, Carolina da S. G. Pedrosa, Leticia R. Q. Souza, James J. Russo, Minchen Chien
Publikováno v:
Journal of Antimicrobial Chemotherapy
Background Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. SARS-CoV-2 nsp12, its RNA polymerase, shares homology in the nucleotid
Autor:
Fiorella Ghisays, Claudia Canasto-Chibuque, Marcel Hohl, Thomas Tuschl, Aitor Garzia, John H.J. Petrini, Hexiao Wang, Sharon A. Savage
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the subtelomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however the importance of these structures or th
Autor:
Stefan Weitzer, Katharina Heitmeier, Thomas Tuschl, Carla Schmidt, Samoil Sekulovski, Silvia Panizza, Pascal Devant, Frank Baas, Simon Trowitzsch, Marie Barth, Javier Martinez, Tasos Gogakos, Anda Pitiriciu, E.P. Ramsay
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur in patients with pontocerebellar hypoplasia (PCH), however, their role in the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae00805e04bdd8666fb8bbc2f817d445
https://doi.org/10.1101/2020.08.03.234229
https://doi.org/10.1101/2020.08.03.234229
Autor:
Hermann Steller, Joe Rodriguez, Cindy Meyer, Daniel Briskin, Sigi Benjamin-Hong, Stefanie Gerstberger, Thomas Tuschl, Claudia Bognanni, Kimberly Bogardus
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 758-772 (2017)
Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, bioc
Publikováno v:
Methods. :24-40
Photoactivatable-Ribonucleoside-Enhanced Crosslinking and Immunoprecipitation (PAR-CLIP) in combination with next-generation sequencing is a powerful method for identifying endogenous targets of RNA-binding proteins (RBPs). Depending on the character
Autor:
Arlene Hurley, Miguel Brown, Kimberly Bogardus, Klaas E.A. Max, Kemal M. Akat, Anuoluwapo Sopeyin, Pavel Morozov, Markus F. Neurath, Thomas Tuschl, Youngmin A. Lee, Thomas G. Diacovo, Martin Borggrefe, Kai Hildner
Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. We performed conventional small-RNA-sequencing (sRNA-seq) and sRNA-seq with T4 polynucleotide kinase (PNK) end treatment of tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599ca9fcfb8bfe0a9f379d49dbbb70b3
https://europepmc.org/articles/PMC6538341/
https://europepmc.org/articles/PMC6538341/
Autor:
Saumya Das, K. Mark Ansel, Markus Bitzer, Xandra O. Breakefield, Alain Charest, David J. Galas, Mark B. Gerstein, Mihir Gupta, Aleksandar Milosavljevic, Michael T. McManus, Tushar Patel, Robert L. Raffai, Joel Rozowsky, Matthew E. Roth, Julie A. Saugstad, Kendall Van Keuren-Jensen, Alissa M. Weaver, Louise C. Laurent, Asim B. Abdel-Mageed, Catherine Adamidi, P. David Adelson, Kemal M. Akat, Eric Alsop, Jorge Arango, Neil Aronin, Seda Kilinc Avsaroglu, Azadeh Azizian, Leonora Balaj, Iddo Z. Ben-Dov, Karl Bertram, Robert Blelloch, Kimberly A. Bogardus, Xandra Owens Breakefield, George A. Calin, Bob S. Carter, Al Charest, Clark C. Chen, Tanuja Chitnis, Robert J. Coffey, Amanda Courtright-Lim, Amrita Datta, Peter DeHoff, Thomas G. Diacovo, David J. Erle, Alton Etheridge, Marc Ferrer, Jeffrey L. Franklin, Jane E. Freedman, Timur Galeev, Roopali Gandhi, Aitor Garcia, Mark Bender Gerstein, Vikas Ghai, Ionita Calin Ghiran, Maria D. Giraldez, Andrei Goga, Tasos Gogakos, Beatrice Goilav, Stephen J. Gould, Peixuan Guo, Fred Hochberg, Bo Huang, Matt Huentelman, Craig Hunter, Elizabeth Hutchins, Andrew R. Jackson, M. Yashar S. Kalani, Pinar Kanlikilicer, Reka Agnes Karaszti, Anastasia Khvorova, Yong Kim, Hogyoung Kim, Taek Kyun Kim, Robert Kitchen, Richard P. Kraig, Anna M. Krichevsky, Raymond Y. Kwong, Minyoung Lee, Noelle L’Etoile, Shawn E. Levy, Feng Li, Jenny Li, Xin Li, Gabriel Lopez-Berestein, Rocco Lucero, Bogdan Mateescu, A.C. Matin, Klaas E.A. Max, Thorsten R. Mempel, Cindy Meyer, Debasis Mondal, Kenneth Jay Mukamal, Oscar D. Murillo, Thangamani Muthukumar, Deborah A. Nickerson, Christopher J. O’Donnell, Dinshaw J. Patel, James G. Patton, Anu Paul, Elaine R. Peskind, Mitch A. Phelps, Chaim Putterman, Peter J. Quesenberry, Joseph F. Quinn, Saritha Ranabothu, Shannon Jiang Rao, Cristian Rodriguez-Aguayo, Anthony Rosenzweig, Marc S. Sabatine, Nikita A. Sakhanenko, Julie Anne Saugstad, Thomas D. Schmittgen, Neethu Shah, Ravi Shah, Kerby Shedden, Jian Shi, Anil K. Sood, Anuoluwapo Sopeyin, Ryan M. Spengler, Robert Spetzler, Srimeenakshi Srinivasan, Sai Lakshmi Subramanian, Manikkam Suthanthiran, Kahraman Tanriverdi, Yun Teng, Muneesh Tewari, William Thistlethwaite, Thomas Tuschl, Karolina Kaczor Urbanowicz, Kasey C. Vickers, Olivier Voinnet, Kai Wang, Zhiyun Wei, Howard L. Weiner, Zachary R. Weiss, Zev Williams, David T.W. Wong, Prescott G. Woodruff, Xinshu Xiao, Irene K. Yan, Ashish Yeri, Bing Zhang, Huang-Ge Zhang
Publikováno v:
Das, Saumya; Ansel, K Mark; Bitzer, Markus; Breakefield, Xandra O; Charest, Alain; Galas, David J; et al.(2019). The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell, 177(2), 231-242. doi: 10.1016/j.cell.2019.03.023. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/42g411w7
© 2019 Elsevier Inc. The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800e9cd219516f263350ecb4f3aff02d
https://europepmc.org/articles/PMC6601620/
https://europepmc.org/articles/PMC6601620/
Publikováno v:
Lupus Science & Medicine
Single-cell RNA sequencing (scRNA-seq) has recently undergone rapid advances in the development of this technology, leading to high throughput and accelerating discovery in many biological systems and diseases. The single-cell resolution of the techn
Autor:
Kostas C. Nikolaou, Marc W. Schmid, Hasan Vatandaslar, Thomas Tuschl, Cindy Meyer, Markus Stoffel
Publikováno v:
Cell Reports, 29 (2)
Cell Reports, Vol 29, Iss 2, Pp 283-300.e8 (2019)
Cell Reports, Vol 29, Iss 2, Pp 283-300.e8 (2019)
The regulation of hepatic gene expression has been extensively studied at the transcriptional level; however, the control of metabolism through posttranscriptional gene regulation by RNA-binding proteins in physiological and disease states is less un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc32e2f61a776a6698e2d6f4e8dc98d