Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Robert Landick"'
Autor:
Hannah Steinert, Florian Sochor, Anna Wacker, Janina Buck, Christina Helmling, Fabian Hiller, Sara Keyhani, Jonas Noeske, Steffen Grimm, Martin M Rudolph, Heiko Keller, Rachel Anne Mooney, Robert Landick, Beatrix Suess, Boris Fürtig, Jens Wöhnert, Harald Schwalbe
Publikováno v:
eLife, Vol 6 (2017)
In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformational refol
Externí odkaz:
https://doaj.org/article/9ca65ffa9a5e4f31902497f97157d4fa
Autor:
Robert Landick
Publikováno v:
Annual Review of Microbiology. 75:291-314
Cellular life depends on transcription of DNA by RNA polymerase to express genetic information. RNA polymerase has evolved not just to read information from DNA and write it to RNA but also to sense and process information from the cellular and extra
Autor:
Gene-Wei Li, Timothy T. Harden, Jeff Gelles, Jean-Benoît Lalanne, Jane Kondev, Ann Hochschild, Mathew Chamberlain, Karina S. Herlambang, Christopher D. Wells, Robert Landick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
RNA polymerases (RNAPs) transcribe genes through a cycle of recruitment to promoter DNA, initiation, elongation, and termination. After termination, RNAP is thought to initiate the next round of transcription by detaching from DNA and rebinding a new
Publikováno v:
Biochemistry
In all domains of life, multisubunit RNA polymerases (RNAPs) catalyze both the extension of mRNA transcripts by nucleotide addition and the hydrolysis of RNA, which enables proofreading by removal of misincorporated nucleotides. A highly conserved ca
Autor:
Yu Bao, Robert Landick
Publikováno v:
Proc Natl Acad Sci U S A
The catalytic trigger loop (TL) in RNA polymerase (RNAP) alternates between unstructured and helical hairpin conformations to admit and then contact the NTP substrate during transcription. In many bacterial lineages, the TL is interrupted by insertio
Autor:
Paul Dominic B. Olinares, Robert Landick, Carolina Hernández, Elizabeth A. Campbell, Edward T. Eng, James Chen, Eliza Llewellyn, David E. Shaw, Seth A. Darst, Brandon Malone, Young Joo Choi, Qi Wang, Brian T. Chait, Xinyun Cao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 genome is replicated and transcribed by its RNA-dependent RNA polymerase (RdRp), which is the target for antivirals such
Autor:
Xinyun Cao, Edward T. Eng, Elizabeth A. Campbell, Brian T. Chait, Brandon Malone, Paul Dominic B. Olinares, James Chen, Eliza Llewellyn, David E. Shaw, Robert Landick, Qi Wang, Carolina Hernández, Young Joo Choi, Seth A. Darst
Backtracking, the reverse motion of the transcriptase enzyme on the nucleic acid template, is a universal regulatory feature of transcription in cellular organisms but its role in viruses is not established. Here we present evidence that backtracking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49d10f7aaf88e12f32c5fa72e3b347b
https://doi.org/10.1101/2021.03.13.435256
https://doi.org/10.1101/2021.03.13.435256
Publikováno v:
The FASEB Journal. 33
Autor:
Jeff Gelles, Rachel A. Mooney, Ivan R Corrêa Jnr, Robert Landick, Sarah K Stumper, Harini Ravi, Larry J. Friedman, Anne Gershenson
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
RNA polymerases (RNAPs) contain a conserved ‘secondary channel’ which binds regulatory factors that modulate transcription initiation. In Escherichia coli, the secondary channel factors (SCFs) GreB and DksA both repress ribosomal RNA (rRNA) trans
Autor:
Tricia A. Windgassen, Tatiana V. Mishanina, Xien Yu Chua, Rachel A. Mooney, Robert Landick, Jason Saba, Dhananjaya Nayak
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise. Althou