Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Stephen Douthwaite"'
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Guerin, F, Rose, S, Cattoir, V & Douthwaite, S 2020, ' Helcococcus kunzii methyltransferase Erm(47) responsible for MLSB resistance is induced by diverse ribosome-targeting antibiotics ', Journal of Antimicrobial Chemotherapy, vol. 75, no. 2, pp. 371-378 . https://doi.org/10.1093/jac/dkz441
Journal of Antimicrobial Chemotherapy, 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, 75 (2), pp.371-378. ⟨10.1093/jac/dkz441⟩
Guerin, F, Rose, S, Cattoir, V & Douthwaite, S 2020, ' Helcococcus kunzii methyltransferase Erm(47) responsible for MLSB resistance is induced by diverse ribosome-targeting antibiotics ', Journal of Antimicrobial Chemotherapy, vol. 75, no. 2, pp. 371-378 . https://doi.org/10.1093/jac/dkz441
ObjectivesTo determine the mechanism of induction of erm(47) and its atypical expression in the Gram-positive opportunistic pathogen Helcococcus kunzii, where it confers resistance to a subset of clinically important macrolide, lincosamide and strept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba84bd8d9c09ac1561b393533713072
https://univ-rennes.hal.science/hal-02365113/document
https://univ-rennes.hal.science/hal-02365113/document
Autor:
Alexander S. Mankin, Stephen Douthwaite, Nora Vázquez-Laslop, Sung Ryeol Park, Mashal M. Almutairi, Douglas A. Hansen, Simon Rose, David H. Sherman
Publikováno v:
Almutairi, M M, Park, S R, Rose, S, Hansen, D A, Vázquez-Laslop, N, Douthwaite, S, Sherman, D H & Mankin, A S 2015, ' Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides ', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 42, pp. 12956-12961 . https://doi.org/10.1073/pnas.1512090112
Ketolides are promising new antimicrobials effective against a broad range of Gram-positive pathogens, in part because of the low propensity of these drugs to trigger the expression of resistance genes. A natural ketolide pikromycin and a related com
Autor:
Stephen Douthwaite, Henrik Nielsen, Simon Rose, Kenneth H Seistrup, Harald Huber, Ulf Birkedal
Publikováno v:
Seistrup, K H, Rose, S, Birkedal, U, Nielsen, H, Huber, H & Douthwaite, S 2017, ' Bypassing rRNA methylation by RsmA/Dim1during ribosome maturation in the hyperthermophilic archaeon Nanoarchaeum equitans ', Nucleic Acids Research, vol. 45, no. 4, pp. 2007-2015 . https://doi.org/10.1093/nar/gkw839
Nucleic Acids Research
Nucleic Acids Research
In all free-living organisms a late-stage checkpoint in the biogenesis of the small ribosomal subunit involves rRNA modification by an RsmA/Dim1 methyltransferase. The hyperthermophilic archaeon Nanoarchaeum equitans, whose existence is confined to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df266633403113ec7bc02338a035aaa2
https://findresearcher.sdu.dk:8443/ws/files/135012733/Bypassing_rRNA_methylation_by_RsmA_Dim1during_ribosome_maturation_in_the_hyperthermophilic_archaeon_Nanoarchaeum_equitans.pdf
https://findresearcher.sdu.dk:8443/ws/files/135012733/Bypassing_rRNA_methylation_by_RsmA_Dim1during_ribosome_maturation_in_the_hyperthermophilic_archaeon_Nanoarchaeum_equitans.pdf
Publikováno v:
Poehlsgaard, J, Møller Andersen, N, Warrass, R & Douthwaite, S R 2012, ' Visualizing the 16-Membered Ring Macrolides Tildipirosin and Tilmicosin Bound to Their Ribosomal Site ', A C S Chemical Biology, vol. 7, pp. 1351-5 . https://doi.org/10.1021/cb300105p
The veterinary antibiotic tildipirosin (20,23-dipiperidinyl-mycaminosyl-tylonolide, Zuprevo) was developed recently to treat bovine and swine respiratory tract infections caused by bacterial pathogens such as Pasteurella multocida. Tildipirosin is a
Publikováno v:
Johansen, S K, Maus, C E, Plikaytis, B B & Douthwaite, S R 2006, ' Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2´-O-methylations in 16S and 23S rRNAs ', Molecular Cell, vol. 23, pp. 173-182 . https://doi.org/10.1016/j.molcel.2006.05.044, https://doi.org/10.1016/j.molcel.2006.05.044
The cyclic peptide antibiotics capreomycin and viomycin are generally effective against the bacterial pathogen Mycobacterium tuberculosis. However, recent virulent isolates have become resistant by inactivation of their tlyA gene. We show here that t
Autor:
Andreas Bechthold, Irina Treede, Lene Jakobsen, Birte Vester, Finn Kirpekar, Stephen Douthwaite, Gabriele Weitnauer
Publikováno v:
Molecular Microbiology. 49:309-318
Avilamycin is an orthosomycin antibiotic that has shown considerable potential for clinical use, although it is presently used as a growth promoter in animal feed. Avilamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subuni
Autor:
Stephen Douthwaite, Mingfu Liu
Publikováno v:
Molecular Microbiology. 44:195-204
Summary Bacteria tune the function of their ribosomes by methylating specific rRNA nucleotides. Nucleotide G745 in Escherichia coli 23S rRNA is methylated by the methyltransferase enzyme RrmA, whereas in Streptomyces fradiae, the neighbouring nucleot
Autor:
Birte Vester, Stephen Douthwaite
This chapter concentrates on resistance to a subset of antibiotics, the 14-membered ring macrolides, and considers their fate as effective antibacterial agents now that resistance is widespread among bacterial pathogens. The ribosome target site for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d5bdd1e675cae039a3fb9ffb1cbdfb
https://doi.org/10.1128/9781555818142.ch35
https://doi.org/10.1128/9781555818142.ch35
Autor:
Stephen Douthwaite, Champney Ws
Publikováno v:
Europe PubMed Central
Ketolides are the most recent generation of antimicrobials derived from the 14-membered ring macrolide, erythromycin A. The main structural feature that differentiates ketolides from erythromycin is the keto group, which replaces the l-cladinose moie
Autor:
Alexander S. Mankin, Liqun Xiong, Stephen Douthwaite, Dean L. Shinabarger, Niels Møller Andersen, Steven Swaney, Patricia Kloss
Publikováno v:
Xiong, L, Kloss, P, Douthwaite, S, Møller Andersen, N, Swaney, S, Shinabarger, D L & Mankin, A S 2000, ' Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action ', Journal of Bacteriology, vol. 182, no. 19, pp. 5325-5331 .
Oxazolidinone antibiotics inhibit bacterial protein synthesis by interacting with the large ribosomal subunit. The structure and exact location of the oxazolidinone binding site remain obscure, as does the manner in which these drugs inhibit translat