Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kevin J. Curran"'
Autor:
Liora M. Schultz, Anne Eaton, Christina Baggott, Jenna Rossoff, Snehit Prabhu, Amy K. Keating, Christa Krupski, Holly Pacenta, Christine L. Philips, Julie-An Talano, Amy Moskop, Susanne H.C. Baumeister, Gary Douglas Myers, Nicole A. Karras, Patrick A. Brown, Muna Qayed, Michelle Hermiston, Prakash Satwani, Rachel Wilcox, Cara A. Rabik, Vanessa A. Fabrizio, Vasant Chinnabhandar, Michael Kunicki, Sharon Mavroukakis, Emily Egeler, Yimei Li, Crystal L. Mackall, Kevin J. Curran, Michael R. Verneris, Theodore W. Laetsch, Heather Stefanski
Publikováno v:
Journal of Clinical Oncology. 41:354-363
PURPOSE Nonresponse and relapse after CD19-chimeric antigen receptor (CAR) T-cell therapy continue to challenge survival outcomes. Phase II landmark data from the ELIANA trial demonstrated nonresponse and relapse rates of 14.5% and 28%, respectively,
Autor:
Heather, Stefanski, Anne, Eaton, Christina, Baggott, Jenna, Rossoff, Michael R, Verneris, Amy K, Keating, Snehit, Prabhu, Holly L, Pacenta, Christine L, Phillips, Julie-An, Talano, Amy, Moskop, Steven P, Margossian, Gary Doug, Myers, Nicole A, Karras, Patrick A, Brown, Muna, Qayed, Michelle L, Hermiston, Prakash, Satwani, Christa, Krupski, Rachel, Wilcox, Cara A, Rabik, Vanessa A, Fabrizio, Vasant, Chinnabhandar, A Yasemin, Goksenin, Emily, Egeler, Sharon, Mavroukakis, Kevin J, Curran, Crystal L, Mackall, Theodore W, Laetsch, Liora M, Schultz
Publikováno v:
Blood advances, vol 7, iss 4
Remarkable complete response rates have been shown with tisagenlecleucel, a chimeric antigen receptor (CAR) T-cell therapy targeting CD19, in patients up to age 26 years with refractory/relapsed B-cell acute lymphoblastic leukemia; it is US Food and
Autor:
Audrey Mauguen, Snehit Prabhu, Christine L Phillips, Kevin J. Curran, Michael Kunicki, Prakash Satwani, Theodore W. Laetsch, Rachel Wilcox, Muna Qayed, Vasant Chinnabhandar, Crystal L. Mackall, Steven P. Margossian, Michael R. Verneris, Michelle L. Hermiston, Vanessa A Fabrizio, Christina Baggott, Julie-An An Talano, Emily Egeler, Gary Doug Myers, A. Yasemin Goksenin, Amy Moskop, Cara A Rabik, Holly L Pacenta, Amy K. Keating, Jenna Rossoff, Christa Krupski, Heather E. Stefanski, Patrick A. Brown, Nicole Karras, Jaap Jan Boelens, Sharon Mavroukakis, Liora M. Schultz
Publikováno v:
Blood advances, vol 6, iss 7
Chimeric antigen receptor (CAR) T cells provide a therapeutic option in hematologic malignancies. However, treatment failure after initial response approaches 50%. In allogeneic hematopoietic cell transplantation, optimal fludarabine exposure improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab5a5590ca98bdc6c2ccd6b052b9feb
https://escholarship.org/uc/item/6xt142fk
https://escholarship.org/uc/item/6xt142fk
Autor:
Andromachi Scaradavou, Richard J. O'Reilly, Jaap Jan Boelens, Farid Boulad, Susan E. Prockop, Barbara Spitzer, Ichelle van Roessel, Andrew L. Kung, Maria Cancio, Kevin J. Curran, Nancy A. Kernan, Elizabeth Klein
Publikováno v:
Cytotherapy
An association between early CD4+ T cell immune reconstitution (CD4+ IR) and survival after T-replete allogeneic hematopoietic cell transplantation (HCT) has been previously reported. Here we report validation of this relationship in a separate cohor
Autor:
Michael Kunicki, Sharon Mavroukakis, Cara A Rabik, Christine L Phillips, Amy K. Keating, Jenna Rossoff, Christa Krupski, Rachel Wilcox, Amy Moskop, Adam Lane, Nicole Karras, Kevin J. Curran, A. Yasemin Goksenin, Crystal L. Mackall, Vasant Chinnabhandar, Emily Egeler, Heather E. Stefanski, Michelle L. Hermiston, Julie-An An Talano, Theodore W. Laetsch, Gary Doug Myers, Prakash Satwani, Snehit Prabhu, Christina Baggott, Steven P. Margossian, Patrick A. Brown, Muna Qayed, Vanessa A Fabrizio, Holly L Pacenta, Michael R. Verneris, Liora M. Schultz
Publikováno v:
Blood Advances
Key Points CD19 CAR therapy for R/R EM disease, particularly CNS, offers a beneficial option with similar toxicity and survival to BM disease.There was no increased cytokine release syndrome or neurotoxicity in patients with R/R EM disease, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5643a68fa7ec55f29728456a9d6f1876
https://escholarship.org/uc/item/1g83m8ch
https://escholarship.org/uc/item/1g83m8ch
Autor:
Steven P. Margossian, Rachel Wilcox, Michelle L. Hermiston, Holly L Pacenta, Heather E. Stefanski, Christina Baggott, Muna Qayed, Vanessa A Fabrizio, G.D. Myers, Snehit Prabhu, Vasant Chinnabhandar, Kevin J Curran, Michael R. Verneris, A. Yasemin Goksenin, Theodore W. Laetsch, Prakash Satwani, Christine L Phillips, Julie-An Talano, Crystal L. Mackall, Michael Kunicki, Liora M. Schultz, Amy Moskop, Nicole Karras, Patrick A. Brown, Cara A Rabik, Amy K. Keating, Jenna Rossoff, Christa Krupski
Publikováno v:
Blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d233911e1462c7c5bebdda65fda5c0
https://europepmc.org/articles/PMC8617436/
https://europepmc.org/articles/PMC8617436/
Autor:
Heather E. Stefanski, Liora M. Schultz, Yasemin Goksenin, Michelle L. Hermiston, Vanessa A Fabrizio, Christina Baggott, Nicole Karras, M. Christa Krupski, Vasant Chinnabhandar, Steven P. Margossian, Holly L Pacenta, Christine L Phillips, Douglas Myers, Kevin J. Curran, Lauren Pommert, Rachel Wilcox, Patrick A. Brown, Muna Qayed, Amy K. Keating, Amy Moskop, Erin H. Breese, Michael R. Verneris, Jenna Rossoff, Cara A Rabik, Crystal L. Mackall, Theodore W. Laetsch, Prakash Satwani, Snehit Prabhu, Julie-An Talano, Erin M. Guest
Publikováno v:
Blood advances, vol 6, iss 14
Infants with B-cell acute lymphoblastic leukemia (B-ALL) have poor outcomes because of chemotherapy resistance leading to high relapse rates. Tisagenlecleucel, a CD19-directed chimeric antigen receptor T-cell (CART) therapy, is US Food and Drug Admin
Autor:
Neerav Shukla, Kavitha Ramaswamy, Sanam Shahid, Christopher J. Forlenza, Jae H. Park, Nancy A. Kernan, Karlo Perica, Kevin J. Curran, Audrey Mauguen, Jaap Jan Boelens, Peter G. Steinherz, Steven P. Margossian, Jessica Flynn
Publikováno v:
Transplant Cell Ther
Chimeric antigen receptor (CAR) T cells achieve response and durable remission in patients with relapsed/refractory (R/R) B cell malignancies. Following collection of patient T cells, chemotherapy ("bridging chemotherapy") is utilized during the manu
Autor:
Audrey Mauguen, Brian C. Shaffer, Ichelle van Roessel, Richard J. O'Reilly, Michael Scordo, Nancy A. Kernan, Christina Cho, Andrew L. Kung, Andromachi Scaradavou, Maria Cancio, Sergio Giralt, Miguel-Angel Perales, Barbara Spitzer, Kevin J. Curran, Madhavi Lakkaraja, Esperanza B. Papadopoulos, Elizabeth Klein, Sean M. Devlin, Farid Boulad, Susan E. Prockop, Ann A. Jakubowski, Gunjan L. Shah, Roni Tamari, Jaap Jan Boelens, Scott Avecilla, Josel D. Ruiz
Publikováno v:
Blood advances. 6(3)
Traditional weight-based dosing results in variable rabbit antithymocyte globulin (rATG) clearance that can delay CD4+ T-cell immune reconstitution (CD4+ IR) leading to higher mortality. In a retrospective pharmacokinetic/pharmacodynamic (PK/PD) anal
Autor:
Andromachi Scaradavou, Maria Cancio, Celina L. Szanto, Mirjam E. Belderbos, Elizabeth Klein, Wouter J.W. Kollen, Farid Boulad, Nancy A. Kernan, Dorine Bresters, Marc Bierings, Stefan Nierkens, Kevin J. Curran, Barbara Spitzer, Coco de Koning, Jurgen Langenhorst, Jaap Jan Boelens, Birgitta Versluijs, Caroline A. Lindemans, Susan E. Prockop, Alwin D. R. Huitema, Ichelle van Roessel, Richard J. O'Reilly
Publikováno v:
Blood
Acute graft-versus-host-Disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). We previously showed that early CD4+ T-cell immune reconstitution (IR; CD4+ IR) predicts survival after HCT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5555c041f4a96722046831f6ef4a6558
https://europepmc.org/articles/PMC7986048/
https://europepmc.org/articles/PMC7986048/