Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katsuhiko Yoshizawa"'
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by the loss of photoreceptor cells leading to a reduction of the peripheral visual field (known as tunnel vision) and eventually to blindness. N-Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d180547e20336589579f423336456ce7
https://doi.org/10.1016/b978-0-12-809468-6.00005-x
https://doi.org/10.1016/b978-0-12-809468-6.00005-x
Autor:
Yuko Emoto, Nobuaki Shikata, Katsuhiko Yoshizawa, Yuichi Kinoshita, Airo Tsubura, Michiko Yuki, Takashi Yuri, Kazutoshi Sayama
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 252:1377-1384
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative human diseases characterized by the loss of photoreceptor cells by apoptosis and eventual blindness. A single intraperitoneal (ip) injection of N-methyl-N-nitrosourea (MNU) causes ph
Publikováno v:
ACTA HISTOCHEMICA ET CYTOCHEMICA. 36:263-270
Retinitis pigmentosa (RP) is a human disease characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. Establishment of reliable animal models is essential for better understanding of this disease and app
Autor:
Shinji Ueno, Mineo Kondo, Katsuji Kiuchi, Kaei Moriguchi, Yozo Miyake, Airo Tsubura, Miyo Matsumura, Katsuhiko Yoshizawa
Publikováno v:
Current Eye Research. 26:355-362
Purpose. A single intraperitoneal injection of 60 mg/kg body weight of N -methyl- N -nitrosourea (MNU) into rats results in retinal degeneration over a 7-day period in all treated animals. The purpose of this study was to determine whether nicotinami
Publikováno v:
Experimental Eye Research. 74:383-392
In previous studies, it was found that a single systemic administration of N-methyl-N-nitrosourea (MNU) to rats and mice resulted in the retinal degeneration in all treated animals over a 7 day period. Retinal degeneration was due to photoreceptor ce
Autor:
Hideto Senzaki, Yasuhiko Kiyozuka, Katsuhiko Yoshizawa, Katsuji Kiuchi, Nobuaki Shikata, Jihong Yang, Hiroyuki Nambu, Airo Tsubura
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology. 240:214-219
The effect of a caspase-3 inhibitor on retinal degeneration in C3H mice carrying the rd gene, a mutation of a rod-specific phosphodiesterase, was investigated.A quantity of 2 mg/kg of Ac-DEVD-CHO, as inhibitor, was injected intraperitoneally every ot
Autor:
Yasuhiko Kiyozuka, Yuji Oishi, Katsuhiko Yoshizawa, Hirohiko Miki, Nobuaki Shikata, Jihong Yang, Hideto Senzaki, Airo Tsubura, Yoshiko Uemura
Publikováno v:
Experimental Eye Research. 71:629-635
The effect of a caspase-3 inhibitor on N -methyl- N -nitrosourea (MNU)-induced retinal degeneration was investigated. Sixty mg kg(-1)MNU was given intraperitoneally to 50 day old female Sprague-Dawley rats, and 4000 ng Ac-DEVD-CHO, a caspase-3 inhibi
Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by the loss of photoreceptor cells leading to a reduction of the peripheral visual field (known as tunnel vision) and eventually to blindness. N -Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::238a7d3abbc0712c9e1bd96be6dbaedd
https://doi.org/10.1016/b978-0-12-415894-8.00006-3
https://doi.org/10.1016/b978-0-12-415894-8.00006-3
Autor:
Norihisa Uehara, Airo Tsubura, Tomo Sasaki, Akiko Harauma, Toru Moriguchi, Katsuhiko Yoshizawa, Naoki Ohara, Hideho Takada, Maki Kuro
Publikováno v:
The British journal of nutrition. 109(8)
Fatty acids and their derivatives play a role in the response to retinal injury. The effects of dietary arachidonic acid (AA) supplementation on N-methyl-N-nitrosourea (MNU)-induced retinal degeneration was investigated in young Lewis rats during the
Autor:
Airo, Tsubura, Yen-Chang, Lai, Hisanori, Miki, Tomo, Sasaki, Norihisa, Uehara, Takashi, Yuri, Katsuhiko, Yoshizawa
Publikováno v:
In vivo (Athens, Greece). 25(1)
N-Methyl-N-nitrosourea (MNU) is a direct-acting alkylating agent that interacts with DNA. Accumulation of mutations may enhance cancer risk in target organs or cause cell death in susceptible tissues or cells when excessive DNA damage is not repaired