Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jianhai Du"'
Autor:
Kaizheng Gong, Xinnong Liu, Brianna Ritz, Jiancheng Huang, Jianhai Du, Chen Zhao, Yekai Wang, Rong Xu
Publikováno v:
J Biol Chem
Defects in energy metabolism in either the retina or the immediately adjacent retinal pigment epithelium (RPE) underlie retinal degeneration, but the metabolic dependence between retina and RPE remains unclear. Nitrogen-containing metabolites such as
Autor:
Patrick A. Scott, Kevin C. Dean, Henry J. Kaplan, Enzo Fortuny, Ashwini Kini, Yao Chen, Yongqing Liu, Eric V. Vukmanic, Robert F. James, Xiaoqin Lu, Wei Wang, Xiao Liu, Tingting Liu, Lei Jin, Yekai Wang, Jianhai Du, Qingxian Lu, Douglas Emery, Douglas C. Dean, San Joon Lee
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1323-1334.e4 (2019)
Cell reports
Cell reports
SUMMARY Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and nighttime vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual
Autor:
Jianhai Du, Brent A. Bell, Kathleen Boesze-Battaglia, E. Dale Abel, Erik Massenzio, Ivy S. Samuels, Nancy J. Philp, John Y. S. Han, Neal S. Peachey, Aditi Swarup
Publikováno v:
American Journal of Physiology-Cell Physiology. 316:C121-C133
The retina is one of the most metabolically active tissues in the body and utilizes glucose to produce energy and intermediates required for daily renewal of photoreceptor cell outer segments. Glucose transporter 1 (GLUT1) facilitates glucose transpo
Autor:
Xiantao Sun, Biao Yan, Jiancheng Huang, Guohua Liu, Jianhai Du, Chen Zhao, Chao Jiang, Zhichun Jiang, Shu-Jie Zhang, Shun Gu, Meng Chen, Roxana A. Radu, Xue Chen, Douglas Vollrath
Publikováno v:
Theranostics
Retinal pigment epithelial (RPE) degeneration is potentially involved in the pathogenesis of several retinal degenerative diseases. mTORC1 signaling is shown as a crucial regulator of many biological processes and disease progression. In this study,
Autor:
Elizabeth Gregor, Siyan Zhu, Fanyi Zhong, Allison Grenell, Yekai Wang, Daniel Lohner, Jianhai Du, Jiangjiang Zhu, Michelle Yam, Allison Hauer
Publikováno v:
Neurobiology of Aging. 71:223-233
Aging is a major risk factor for age-related ocular diseases including age-related macular degeneration in the retina and retinal pigment epithelium (RPE), cataracts in the lens, glaucoma in the optic nerve, and dry eye syndrome in the cornea. We use
Publikováno v:
Amino Acids
The retina is one of the most energy-demanding tissues in the human body. Photoreceptors in the outer retina rely on nutrient support from the neighboring retinal pigment epithelium (RPE), a monolayer of epithelial cells that separate the retina and
Autor:
Shaoxue Zeng, Mark C Gillies, Ting Zhang, Ling Zhu, Bo Li, Siyan Zhu, Liu Wei, Rui Zhang, Rong Xu, Yekai Wang, Jianhai Du
Publikováno v:
iScience
iScience, Vol 23, Iss 11, Pp 101672-(2020)
iScience, Vol 23, Iss 11, Pp 101672-(2020)
Summary Photoreceptors, especially cones, which are enriched in the human macula, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is a
Autor:
Abbi L. Engel, YeKai Wang, Thomas H. Khuu, Emily Worrall, Megan A. Manson, Rayne R. Lim, Kaitlen Knight, Aya Yanagida, Jian Hua Qi, Aravind Ramakrishnan, Richard G Weleber, Michael L. Klein, David J. Wilson, Bela Anand-Apte, James B. Hurley, Jianhai Du, Jennifer R. Chao
Publikováno v:
Exp Eye Res
Sorsby Fundus Dystrophy (SFD) is a rare form of macular degeneration that is clinically similar to age-related macular degeneration (AMD), and a histologic hallmark of SFD is a thick layer of extracellular deposits beneath the retinal pigment epithel
Autor:
Shaoxue Zeng, Siyan Zhu, Bo Li, Liu Wei, Ting Zhang, Ling Zhu, Yekai Wang, Mark C Gillies, Jianhai Du, Rong Xu, Rui Zhang
Photoreceptors, especially cones, which are enriched in the human macula, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f9b3e2aa821114213f5a868dac41d97
https://doi.org/10.1101/2020.07.10.196295
https://doi.org/10.1101/2020.07.10.196295
Autor:
Jianhai Du, Weiyong Shen, Abbi L. Engel, Yekai Wang, Jennifer R Chao, Rui Zhang, Bo Li, Mark C Gillies
Publikováno v:
J Proteome Res
Mitochondrial respiration in mammalian cells not only generates ATP to meet their own energy needs but also couples with biosynthetic pathways to produce metabolites that can be exported to support neighboring cells. However, how defects in mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e960aa675107abf28119087713fe4606
https://doi.org/10.1101/2020.05.11.086827
https://doi.org/10.1101/2020.05.11.086827