Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Michael E Boulton"'
Publikováno v:
Cells, Vol 9, Iss 4, p 905 (2020)
Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent retina and to determine if this is impaired in diabetic retinopathy. C57BL/6J mice and Bio-Bree
Externí odkaz:
https://doaj.org/article/86a8d53e74f94669a9dc5c48e2ffd846
Autor:
Shizuo Akira, Sergio Li Calzi, Yvonne Adu-Agyeiwaah, Priyamvada M Pitale, Maria B. Grant, W. Timothy Garvey, Takashi Satoh, Machelle T. Pardue, Irina V. Saltykova, Michael E. Boulton, Marina S. Gorbatyuk, Mohammad Athar, Oleg S. Gorbatyuk
Publikováno v:
Diabetes
The current understanding of the molecular pathogenesis of diabetic retinopathy does not provide a mechanistic link between early molecular changes and the subsequent progression of the disease. In this study, we found that human diabetic retinas ove
Autor:
Bomina Park, Sheik Pran Babu Sardar Pasha, Kamakshi L. Sishtla, Gabriella D. Hartman, Xiaoping Qi, Michael E. Boulton, Timothy W. Corson
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15595
Neovascular or “wet” age-related macular degeneration (nAMD) is a leading cause of blindness among older adults. Choroidal neovascularization (CNV) is a major pathological feature of nAMD, in which abnormal new blood vessel growth from the choroi
Autor:
Juliana Godoy, Maria B. Grant, Xiaoping Qi, Carolina Francelin, Juliete A. F. Silva, Michael E. Boulton
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology
Purpose Previously, we reported that the intravenous injection of bone marrow-derived cells (BMDC) infected with lentivirus expressing the human RPE65 gene resulted in the programming of BMDC to promote visual recovery in a mouse model of age-related
Autor:
Julia V. Busik, Michael E. Boulton, Sayak K. Mitter, Yuanqing Yan, Maria B. Grant, Xiaoping Qi
Publikováno v:
Cells
Volume 9
Issue 4
Cells, Vol 9, Iss 905, p 905 (2020)
Volume 9
Issue 4
Cells, Vol 9, Iss 905, p 905 (2020)
Retinal homeostasis is under both diurnal and circadian regulation. We sought to investigate the diurnal expression of autophagy proteins in normal rodent retina and to determine if this is impaired in diabetic retinopathy. C57BL/6J mice and Bio-Bree
LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target
Autor:
Ebraheim N. Ismail, Rajendra S. Apte, Steven Nusinowitz, James T. Handa, Jeffrey W. Ruberti, Peter Tontonoz, Faryan Tayyari, Goldis Malek, Michael E. Boulton, Mayur Choudhary, Pei-Li Yao, Roxana A. Radu
Publikováno v:
JCI insight, vol 5, iss 1
Effective treatments and animal models for the most prevalent neurodegenerative form of blindness in elderly people, called age-related macular degeneration (AMD), are lacking. Genome-wide association studies have identified lipid metabolism and infl
Autor:
Darrell N. Kotton, Trevor J. McGill, Maria B. Grant, Nutan Prasain, Chao Huang, Kimihiko Banno, Dibyendu Chakraborty, Mohamed Jamal, Yang Lin, Michael P. Murphy, Michael E. Boulton, Cristiano P. Vieira, Xinxin Huang, Sergio Li Calzi, Mariana Dupont, Hyung-Min Chung, Chang-Hyun Gil, Ana Leda F. Longhini, Ping Hu, Mervin C. Yoder, Ram Prasad, Micheli S. Sielski, Jason L. Floyd
Publikováno v:
SSRN Electronic Journal.
Human induced pluripotent stem cells (hiPSC) differentiated into a specific mesoderm subset expressing vascular endothelial growth factor receptor 2, neural cell adhesion molecule 1, and apelin G protein-coupled receptor APJ (called KNA+), possessed
Autor:
Michael E. Boulton, Marina S. Gorbatyuk, Oleg S. Gorbatyuk, Nahum Sonenberg, Yang Hu, Cyril Nii Amankwah Nyankerh, Christopher R. Starr, Xiaoping Qi
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose We reported previously that retinas of mice with inherited retinal degeneration make less protein than retinas of normal mice. Despite recent studies suggesting that diminished protein synthesis rates may contribute to neurologic disorders, a
Autor:
Lyne Racette, Michael E. Boulton, Mervin C. Yoder, Lynn C. Shaw, Seth D. Fortmann, William C. Shelley, Leni Moldovan, Sergio Li Calzi, Judith Quigley, Xiaoping Qi, Maria B. Grant
Publikováno v:
JCI Insight. 4
Retinopathy of prematurity (ROP) is a disorder of the developing retina of preterm infants. ROP can lead to blindness because of abnormal angiogenesis that is the result of suspended vascular development and vaso-obliteration leading to severe retina
Autor:
Sergio Li Calzi, Bokkyoo Jun, Nicolas G. Bazan, Nilanjana Sengupta-Caballero, Lynn C Shaw, Mircea Ivan, Nan Li, Judith Quigley, Maria B. Grant, Michael E. Boulton, Leni Moldovan, Julia V. Busik, Josef Neu
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Low levels of the long chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA) have been implicated in retinopathy of prematurity (ROP). However, oral DHA suffers from poor palatability and is associated with increased bleeding i