Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richard H. Gomer"'
Autor:
Louis A. Cadena, Jacquelyn R. McCullough, David E. Zimmerhanzel, Richard H. Gomer, Ramesh Rijal, Yu Tang
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
mBio
mBio
Little is known about how eukaryotic cells can sense their number or spatial density and stop proliferating when the local density reaches a set value. We previously found that Dictyostelium discoideum accumulates extracellular polyphosphate to inhib
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245924 (2021)
PLoS ONE
bioRxiv
PLoS ONE
bioRxiv
SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein ag
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244762 (2020)
PLoS ONE
PLoS ONE
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes and is characterized by the accumulation of fat in the liver (steatosis). NAFLD can transition into non-alcoholic steatohepatitis (NASH), with liver cell injury,
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Pulmonary fibrosis involves the formation of inappropriate scar tissue in the lungs, but what drives fibrosis is unclear. Sialidases (also called neuraminidases) cleave terminal sialic acids from glycoconjugates. In humans and mice, pulmonary fibrosi
Publikováno v:
mBio, Vol 10, Iss 2, p e00218-19 (2019)
mBio, Vol 10, Iss 2 (2019)
mBio
mBio, Vol 10, Iss 2 (2019)
mBio
Macrophages are a key part of our innate immune system and are responsible for recognizing invading microbes, ingesting them, and sending appropriate signals to other immune cells. We have found that human macrophages can recognize invading yeast pat
Autor:
Yu Tang, Yuantai Wu, Sarah E. Herlihy, Francisco J. Brito-Aleman, Jose H. Ting, Chris Janetopoulos, Richard H. Gomer, Scott D. Emr
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
mBio
mBio, Vol 9, Iss 1, p e02443-17 (2018)
mBio
mBio, Vol 9, Iss 1, p e02443-17 (2018)
In eukaryotic microbes, little is known about signals that inhibit the proliferation of the cells that secrete the signal, and little is known about signals (chemorepellents) that cause cells to move away from the source of the signal. Autocrine prol
Autor:
Jonathan E. Phillips, Richard H. Gomer
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 2, Pp 147-156 (2015)
Disease Models & Mechanisms
Disease Models & Mechanisms
Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available. Children with NCL show a progressive decline in movement, vision and mental abi
Publikováno v:
BMC Immunology
BMC Immunology, Vol 18, Iss 1, Pp 1-15 (2017)
BMC Immunology, Vol 18, Iss 1, Pp 1-15 (2017)
Background Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages can also convert from one of t
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119709 (2015)
PLoS ONE
PLoS ONE, 10(3)
PLoS ONE
PLoS ONE, 10(3)
Monocyte-derived, fibroblast-like cells called fibrocytes are associated with fibrotic lesions. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0edb8f694349df45776ab7d0f09099
https://hdl.handle.net/1887/101066
https://hdl.handle.net/1887/101066
Autor:
Richard H. Gomer, Jonathan E. Phillips
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e96633 (2014)
PLoS ONE, Vol 9, Iss 5, p e96633 (2014)
In Dictyostelium discoideum, the secreted proteins AprA and CfaD function as reporters of cell density and regulate cell number by inhibiting proliferation at high cell densities. AprA also functions to disperse groups of cells at high density by act