Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Richard A, Koup"'
Autor:
Amarendra Pegu, Giulia Fabozzi, Joana Dias, John R. Mascola, Wanwisa Promsote, Cassandra G. Almasri, Richard A. Koup, Lucio Gama, Constantinos Petrovas, John Paul Todd, Jonathan Fintzi, Yoshiaki Nishimura, Mangaiarkarasi Asokan, Kylie March, Malcolm A. Martin, Jeffrey D. Lifson
Publikováno v:
J Clin Invest
Primary HIV-1 infection can be classified into six Fiebig stages based on virological and serological laboratory testing, whereas simian-HIV (SHIV) infection in nonhuman primates (NHPs) is defined in time post-infection, making it difficult to extrap
Autor:
Rachel L. Rutishauser, Peter W. Hunt, Kyle A. Raymond, Daniel C. Douek, Theodore L. Roth, Rafick-Pierre Sekaly, Frederick Hecht, Alexander Marson, Carly E. Starke, Franziska Blaeschke, Steven G. Deeks, Christian Deo T Deguit, Christopher D. Pilcher, Joseph Hiatt, Joseph C. Mudd, Wenxuan Chen, Carolyn P Smullin, Joseph M. McCune, Satish K. Pillai, Melissa R. Krone, Richard A. Koup, Rebecca Hoh, Jeffrey N. Martin, Jason M. Brenchley, Lynn Wang, Rodrigo Matus-Nicodemos
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Autor:
Jumpol Sopanaporn, Weerawan Chuenarom, Boot Keawboon, Dan H. Barouch, Wei Shi, John R. Mascola, Richard A. Koup, Merlin L. Robb, Sandhya Vasan, Rawiwan Imerbsin, Amarendra Pegu, Nelson L. Michael, Dutsadee Inthawong, Alexandra Schuetz, Pornsuk Visudhiphan, Decha Silsorn, Romas Geleziunas, Denise C. Hsu
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009339 (2021)
PLoS Pathogens
PLoS Pathogens
Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after an
Autor:
Jeffrey D. Lifson, John R. Mascola, Sean P. O’Brien, Theodora Hatziioannou, Paul D. Bieniasz, Jason Gorman, Brandon F. Keele, George M. Shaw, Gregory Q. Del Prete, Richard A. Koup, Taina T. Immonen, Adrienne E. Swanstrom, Christine M. Fennessey, Amarendra Pegu, Kathryn E. Foulds, Nicole A. Doria-Rose, Peter D. Kwong, Sung-Youl Ko, Mario Roederer, Carolyn Williamson, Stephen D. Schmidt, Hui Li
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,
Autor:
Solène Fastenackels, Delphine Sauce, Jacques Boddaert, Victor Appay, Véronique Fabre-Mersseman, Laura Papagno, Rima Zoorab, Charles Bayard, Tinhinane Fali, Takuya Yamamoto, Richard A. Koup
Publikováno v:
JCI Insight
JCI Insight, American Society for Clinical Investigation, 2018, 3 (13), ⟨10.1172/jci.insight.95319⟩
JCI Insight, American Society for Clinical Investigation, 2018, 3 (13), ⟨10.1172/jci.insight.95319⟩
The maintenance of effective immunity over time is dependent on the capacity of hematopoietic stem cells (HSCs) to sustain the pool of immunocompetent mature cells. Decline of immune competence with old age may stem from HSC defects, including reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f69398a1b639647bd2f2287429d78e
https://hal.archives-ouvertes.fr/hal-02452400
https://hal.archives-ouvertes.fr/hal-02452400
Autor:
Rajendra Pahwa, Varghese K. George, David Huddleston, David R. Ambrozak, Suresh Pallikkuth, Lesley R. de Armas, Savita Pahwa, Louis Gonzalez, Richard A. Koup, Constantinos Petrovas, Eirini Moysi
Publikováno v:
The Journal of clinical investigation. 128(7)
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral the
Autor:
Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood, VRC 606 Study Team
Publikováno v:
PLoS Medicine, Vol 15, Iss 1, p e1002493 (2018)
PLoS Medicine
PLoS Medicine
Background VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a mo
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev, John T. Patton
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activatio
Autor:
John R. Mascola, Jason M. Brenchley, Richard A. Koup, Eirini Moysi, Mirko Paiardini, Amarendra Pegu, Adrian B. McDermott, David R. Ambrozak, Constantinos Petrovas, Krystelle Nganou Makamdop, Daniel C. Douek, Sara Ferrando-Martinez, Sarah Andrews, David Palesch, George N. Pavlakis
Publikováno v:
The Journal of clinical investigation. 128(5)
LN follicles constitute major reservoir sites for HIV/SIV persistence. Cure strategies could benefit from the characterization of CD8+ T cells able to access and eliminate HIV-infected cells from these areas. In this study, we provide a comprehensive
Autor:
Richard A. Koup, Patrick Younan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Michael G. Katze, Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
PLoS Pathogens
PLoS Pathogens
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however