Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard A, Koup"'
Autor:
Rachel L. Rutishauser, Peter W. Hunt, Kyle A. Raymond, Daniel C. Douek, Theodore L. Roth, Rafick-Pierre Sekaly, Frederick Hecht, Alexander Marson, Carly E. Starke, Franziska Blaeschke, Steven G. Deeks, Christian Deo T Deguit, Christopher D. Pilcher, Joseph Hiatt, Joseph C. Mudd, Wenxuan Chen, Carolyn P Smullin, Joseph M. McCune, Satish K. Pillai, Melissa R. Krone, Richard A. Koup, Rebecca Hoh, Jeffrey N. Martin, Jason M. Brenchley, Lynn Wang, Rodrigo Matus-Nicodemos
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
JCI Insight, Vol 6, Iss 3 (2021)
JCI insight, vol 6, iss 3
Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate seco
Autor:
Jeffrey D. Lifson, John R. Mascola, Sean P. O’Brien, Theodora Hatziioannou, Paul D. Bieniasz, Jason Gorman, Brandon F. Keele, George M. Shaw, Gregory Q. Del Prete, Richard A. Koup, Taina T. Immonen, Adrienne E. Swanstrom, Christine M. Fennessey, Amarendra Pegu, Kathryn E. Foulds, Nicole A. Doria-Rose, Peter D. Kwong, Sung-Youl Ko, Mario Roederer, Carolyn Williamson, Stephen D. Schmidt, Hui Li
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,
Autor:
Jumpol Sopanaporn, Weerawan Chuenarom, Boot Keawboon, Dan H. Barouch, Wei Shi, John R. Mascola, Richard A. Koup, Merlin L. Robb, Sandhya Vasan, Rawiwan Imerbsin, Amarendra Pegu, Nelson L. Michael, Dutsadee Inthawong, Alexandra Schuetz, Pornsuk Visudhiphan, Decha Silsorn, Romas Geleziunas, Denise C. Hsu
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009339 (2021)
PLoS Pathogens
PLoS Pathogens
Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after an
Autor:
Richard A. Koup, Patrick Younan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Michael G. Katze, Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
PLoS Pathogens
PLoS Pathogens
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however
Autor:
Constantinos Petrovas, Manuel Leal, Rafael Luque, Diane V. Havlir, Kapil K. Saharia, Prudence Ive, Sara Ferrando-Martinez, Richard A. Koup, Anne F Luetkemeyer
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
[Background] Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d152ab4f9f6ccd7b0e32861f3e7c455
https://hdl.handle.net/10668/10229
https://hdl.handle.net/10668/10229
Autor:
Takuya Yamamoto, Richard A. Koup, Michael R. Betts, Ole Lund, Marcus Buggert, Johanna Tauriainen, Juliet Wairimu Frederiksen, Marianne Jansson, Martin A. Ivarsson, Jakob Michaëlsson, Anders Sönnerborg, Bo Hejdeman, Annika C. Karlsson
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004251 (2014)
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251
PLoS Pathogens; 10(7), no e1004251 (2014)
PLoS Pathogens
Buggert, M, Tauriainen, J, Yamamoto, T, Frederiksen, J W, Ivarsson, M A, Michaelsson, J, Lund, O, Hejdeman, B, Jansson, M, Sonnerborg, A, Koup, R A, Betts, M R & Karlsson, A C 2014, ' T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+T Cells in HIV Infection ', P L o S Pathogens, vol. 10, no. 7, e1004251 . https://doi.org/10.1371/journal.ppat.1004251
CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exh
Autor:
Ndongala Michel Lubaki, Patrick Younan, Rodrigo I Santos, Michelle Meyer, Mathieu Iampietro, Richard A Koup, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006031 (2016)
PLoS Pathogens
PLoS Pathogens
Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblock
Autor:
John R. Mascola, Barney S. Graham, Laura Novik, Adrian B. McDermott, Richard A. Koup, Eleanor Wilson, Michelle C. Crank, Cynthia S. Hendel, Robert T. Bailer, Mary E. Enama, Julie E. Ledgerwood, Wenjuan Gu, Martha Nason, Gary J. Nabel, Vrc Study Team
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0166393 (2016)
PLoS ONE, Vol 11, Iss 11, p e0166393 (2016)
Background VRC 012 was a Phase I study of a prototype recombinant adenoviral-vector serotype-35 (rAd35) HIV vaccine, the precursor to two recently published clinical trials, HVTN 077 and 083. On the basis of prior evaluation of multiclade rAd5 HIV va
Autor:
Constantinos Petrovas, Julie A Ake, Adrian B. McDermott, Adam K. Wheatley, Richard A. Koup, Takuya Yamamoto, Mario Roederer, Eli Boritz, David R. Ambrozak, Kristin L. Boswell, Mark Connors, Sandeep Narpala, Kaska Wloka, Robert Paris, Richard Haubrich, Daniel C. Douek, Jerome H. Kim, Sam Darko
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 1, p e1003853 (2014)
PLoS Pathogens, Vol 10, Iss 1, p e1003853 (2014)
The interaction between follicular T helper cells (TFH) and B cells in the lymph nodes and spleen has a major impact on the development of antigen-specific B cell responses during infection or vaccination. Recent studies described a functional equiva
Autor:
Richard A. Koup, Njabulo Ngwenyama, Antelmo Haule, Leonard Maboko, Klaus Reither, Michael Hoelscher, Alexandra Schuetz, Christof Geldmacher, Andrea Rachow, Andreas Meyerhans
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE, Vol 6, Iss 11, p e27284 (2011)
PLoS ONE
instname
PLoS ONE, Vol 6, Iss 11, p e27284 (2011)
PLoS ONE
The level of bacterial activity is only poorly defined during asymptomatic Mycobacterium tuberculosis (MTB) infection. The objective was to study the capacity of a new biomarker, the expression of the T cell maturation marker CD27 on MTB-specific CD4