Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pranav Danthi"'
Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Autor:
Andrew T. Abad, Pranav Danthi
Publikováno v:
J Virol
Mammalian orthoreovirus (reovirus) is a double-stranded (ds)RNA virus which encapsidates its 10 genome segments within a double-layered viral particle. Reovirus infection triggers an antiviral response in host cells which serves to limit viral replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0945dfd66086f16bf3262912dbf3cec6
https://doi.org/10.1101/2022.02.25.482062
https://doi.org/10.1101/2022.02.25.482062
Autor:
Asangi R. Kumarapeli, Anthony J. Snyder, Pranav Danthi, Vijayalakshmi Sridharan, Marjan Boerma, Marcelle Dina Zita, Johnasha D. Stuart, Karl W. Boehme, Amairani Paredes, Matthew B Phillips
Publikováno v:
J Virol
Although a broad range of viruses cause myocarditis, the mechanisms that underlie viral myocarditis are poorly understood. Here, we report that the M2 gene is a determinant of reovirus myocarditis. The M2 gene encodes outer capsid protein μ1, which
Successful initiation of infection by many different viruses requires their uptake into the endosomal compartment. While some viruses exit this compartment early, others must reach the degradative, acidic environment of the late endosome. Mammalian o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63adbd5cf2d5588b34faf9a01fb9bca4
https://doi.org/10.1101/2021.09.26.461887
https://doi.org/10.1101/2021.09.26.461887
Publikováno v:
J Virol
The capsids of mammalian reovirus contain two concentric protein shells, the core and the outer capsid. The outer capsid is composed of μ1-σ3 heterohexamers which surround the core. The core is composed of λ1 decamers held in place by σ2. After e
Autor:
Andrew J McNamara, Pranav Danthi
Publikováno v:
J Virol
Viruses commonly antagonize innate immune pathways that are primarily driven by nuclear factor kappa B (NF-κB), interferon regulatory factor (IRF), and the signal transducer and activator of transcription proteins (STAT) family of transcription fact
Autor:
Anthony J. Snyder, Pranav Danthi
Publikováno v:
Journal of Biological Chemistry. 291:26773-26785
Virus-host interactions play a role in many stages of the viral lifecycle, including entry. Reovirus, a model system for studying the entry mechanisms of nonenveloped viruses, undergoes a series of regulated structural transitions that culminate in d
Publikováno v:
Journal of Virology. 90:10951-10962
Proteins that form the reovirus outer capsid play an active role in the entry of reovirus into host cells. Among these, the σ1 protein mediates attachment of reovirus particles to host cells via interaction with cell surface glycans or the proteinac
Publikováno v:
Viruses, Vol 13, Iss 153, p 153 (2021)
Viruses
Viruses
Mammalian orthoreovirus (reovirus), a dsRNA virus with a multilayered capsid, serves as a model system for studying the entry of similar viruses. The outermost layer of this capsid undergoes processing to generate a metastable intermediate. The metas
Autor:
Anthony J. Snyder, Pranav Danthi
Publikováno v:
Journal of Virology. 92
The mammalian orthoreovirus (reovirus) outer capsid, which is composed of 200 μ1/σ3 heterohexamers and a maximum of 12 σ1 trimers, contains all of the proteins that are necessary for attaching to and entering host cells. Following attachment, reov