Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Shimon, Sakaguchi"'
Autor:
Noriko Goda, Shinsuke Sasada, Hideo Shigematsu, Norio Masumoto, Koji Arihiro, Hiroyoshi Nishikawa, Shimon Sakaguchi, Morihito Okada, Takayuki Kadoya
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Purpose FOXP3 + and CD8 + are recognized markers of tumor-infiltrating lymphocytes (TILs) for breast cancer. FOXP3 + TILs are composed of effector Tregs (eTregs) and other subpopulations that are classified by their differences in suppressiv
Externí odkaz:
https://doaj.org/article/70b346668fcf43289c7b737ddf251d88
Autor:
Seishi Ogawa, Katsuyoshi Koh, Kenichi Chiba, Yuki Arakawa, Tomoya Isobe, Satoru Miyano, Shimon Sakaguchi, Satoshi Saida, Hiroko Tanaka, Hirohito Kubota, Ai Okada, Junko Takita, Koichi Oshima, Yuichi Shiraishi, James B. Wing, Katsutsugu Umeda, Keiko Iwaisako, Hidefumi Hiramatsu, Keiji Tasaka, Hiroo Ueno, Mitsuteru Hiwatari, Souichi Adachi, Itaru Kato, Kuniaki Tanaka, Takashi Mikami
Publikováno v:
Cancer Science
Due to the considerable success of cancer immunotherapy for leukemia, the tumor immune environment has become a focus of intense research; however, there are few reports on the dynamics of the tumor immune environment in leukemia. Here, we analyzed t
Autor:
Masao Tanaka, Masaki Hikida, Yoshinaga Ito, Mirei Shirakashi, Takashi Matsuo, Kaoru Sakai, Koichiro Ohmura, Tsuneyo Mimori, Shimon Sakaguchi, Noriko Sakaguchi, Hajime Yoshifuji, Hideki Yokoi, Tatsuaki Tsuruyama, Hiromu Ito, Motomu Hashimoto, Takao Fujii
Publikováno v:
The Journal of Immunology. 202:3161-3172
A defect in TCR-proximal signaling is a major characteristic of CD4 T cells in systemic lupus erythematosus; however, it is not fully known how defects in TCR signaling lead to lupus-like systemic autoimmunity characterized by germinal center develop
Publikováno v:
Immunity. 50:302-316
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell activation an
Autor:
Yohko Kitagawa, Keiko Yasuda, Norihisa Mikami, Masaya Arai, Hitomi Watanabe, Kelvin Y. Chen, Gen Kondoh, Daiya Ohara, Motonao Osaki, Yamami Nakamura, Keiji Hirota, Naganari Ohkura, Shimon Sakaguchi, Ryoji Kawakami, Caleb A. Lareau
Publikováno v:
Immunity. 54(5)
The transcription factor Foxp3 plays crucial roles for Treg cell development and function. Conserved non-coding sequences (CNSs) at the Foxp3 locus control Foxp3 transcription, but how they developmentally contribute to Treg cell lineage specificatio
Autor:
Shimon Sakaguchi, Daisuke Ito, Shigeyuki Nada, Yuhei Kinehara, Hyota Takamatsu, Takashi Hosokawa, Yoshitomo Hayama, Syohei Koyama, Atsushi Kumanogoh, Tetsuya Kimura, Masayuki Nishide, Norihisa Mikami, Kazuya Yamashita, Daisuke Okuzaki, Masato Okada, Takeshi Nakatani, Naganari Ohkura, Yasuhiro Kato, Satoshi Nojima, Tatsusada Okuno, Sujin Kang
Publikováno v:
The Journal of Immunology. 199:2008-2019
Mechanistic target of rapamycin complex (mTORC)1 integrates intracellular sufficiency of nutrients and regulates various cellular functions. Previous studies using mice with conditional knockout of mTORC1 component proteins (i.e., mTOR, Raptor, and R
Publikováno v:
Journal of Allergy and Clinical Immunology. 142:1754-1756
Autor:
Yutaka Shimazu, Yuya Nagai, Sumie Fujii, Masahiro Kawahara, Akifumi Takaori-Kondo, Norimitsu Kadowaki, Yayoi Shimazu, Masakatsu Hishizawa, Hiroyoshi Nishikawa, Noriko Sugino, Shimon Sakaguchi, Masahide Hamaguchi
Publikováno v:
Cancer Immunology Research. 4:136-145
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell leukemia virus type 1. Because of its immunosuppressive property and resistance to treatment, patients with ATL have poor prognoses. ATL cells possess the regulator
Autor:
Naganari Ohkura, Shota Nakamura, Yukinori Okada, Yoshiaki Yasumizu, Yamami Nakamura, Yohko Kitagawa, Daisuke Motooka, Atsushi Tanaka, Shimon Sakaguchi
Publikováno v:
Immunity. 52:1119-1132.e4
The contribution of FOXP3-expressing naturally occurring regulatory T (Treg) cells to common polygenic autoimmune diseases remains ambiguous. Here, we characterized genome-wide epigenetic profiles (CpG methylation and histone modifications) of human
Autor:
Emily E. Vance, Shimon Sakaguchi, Peter Stenzel, Kimberly A. Samson, Paige E. Snow, Michael P. Davey, Clare E. Dawson, Amy E. Moran, Ruth J. Napier, Holly L. Rosenzweig, E. J. Lee
Arthritis in a genetically susceptible SKG strain of mice models a theoretical paradigm wherein autoimmune arthritis arises because of interplay between preexisting autoreactive T cells and environmental stimuli. SKG mice have a point mutation in ZAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d8462aec01bd954188e04fdc016752
https://europepmc.org/articles/PMC6143404/
https://europepmc.org/articles/PMC6143404/