Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Akiyoshi Komuro"'
Autor:
Akira Watanabe, Keiko Funa, Akiyoshi Komuro, Yasuyuki Morishita, Yuma Fuse, Mitsunobu R. Kano, Akifumi Hagiwara, Erik Johansson, Hiroyuki Aburatani, Kohei Miyazono, Caname Iwata
Publikováno v:
Cancer Science. 101:2398-2403
Diffuse-type gastric carcinoma is characterized by rapid progression and poor prognosis. High expression of transforming growth factor (TGF)-β and thick stromal fibrosis are observed in this type of gastric carcinoma. We have previously shown that d
Autor:
Yasuyuki Morishita, Akiyoshi Komuro, Koichi Sugimoto, Kunihiko Kiyono, Mitsunobu R. Kano, Kohei Miyazono, Hiroshi Suzuki, Hironori Matsuyama
Publikováno v:
Cancer Research. 69:8844-8852
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells. Autophagy is emerging as a critical response of normal and cancer cells to environmental change
Autor:
Akira Watanabe, Hiroyuki Miyoshi, Akiyoshi Komuro, Yo Taro Shirai, Mitsunobu R. Kano, Masakazu Yashiro, Hiroyuki Aburatani, Kunihiko Kiyono, Kosei Hirakawa, Hiroshi Suzuki, Yasuyuki Morishita, Erik Johansson, Caname Iwata, Kohei Miyazono, Yoshiko Matsumoto
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Diffuse-type gastric carcinoma is a cancer with poor prognosis that has high levels of transforming growth factor β (TGF-β) expression and thick stromal fibrosis. However, the association of TGF-β signaling with diffuse-type gastric car
Autor:
Nobuhiro Nishiyama, Kunihiko Kiyono, Yasuyuki Morishita, Tomoko Fujii, Kazunori Kataoka, Yasuyoshi Ouchi, Masako Oka, Kosei Hirakawa, Younsoo Bae, Kohei Miyazono, Caname Iwata, Masakazu Yashiro, Akiyoshi Komuro, Mitsunobu R. Kano, Michio Kaminishi
Publikováno v:
Proceedings of the National Academy of Sciences. 104:3460-3465
Transforming growth factor (TGF)-beta plays a pivotal role in regulation of progression of cancer through effects on tumor microenvironment as well as on cancer cells. TGF-beta inhibitors have recently been shown to prevent the growth and metastasis
Autor:
Kouichiro Goto, Takeshi Imamura, Keiji Miyazawa, Akiyoshi Komuro, Kohei Miyazono, Go Kuratomi, Masahiko Shinozaki
Publikováno v:
Biochemical Journal. 386:461-470
Inhibitory Smad, Smad7, is a potent inhibitor of TGF-beta (transforming growth factor-beta) superfamily signalling. By binding to activated type I receptors, it prevents the activation of R-Smads (receptor-regulated Smads). To identify new components
Autor:
Tetsuro Watabe, Akiyoshi Komuro, Mitsunobu R. Kano, Kunihiko Kiyono, Masako Oka, Hiroshi Suzuki, Yasuyuki Morishita, Caname Iwata, Kohei Miyazono
Publikováno v:
Blood. 111(9)
Lymphangiogenesis is induced by various growth factors, including VEGF-C. Although TGF-β plays crucial roles in angiogenesis, the roles of TGF-β signaling in lymphangiogenesis are unknown. We show here that TGF-β transduced signals in human dermal
Autor:
Masao Saitoh, Keiji Miyazawa, Kohei Miyazono, Akiyoshi Komuro, Takeshi Imamura, Takao Yamori, Yoko Yoshida
Publikováno v:
Oncogene. 23(41)
Smad7 negatively regulates transforming growth factor (TGF)-beta superfamily signaling by binding to activated type I receptors, thereby preventing the phosphorylation of receptor-regulated Smads (R-Smads), as well as by recruiting HECT-type E3 ubiqu