Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M. Dutton"'
Publikováno v:
Thyroid. 8:193-196
Our laboratory has shown recently that the thyrotropin receptor (TSHr) is expressed in orbital adipose/connective tissues from patients with Graves' ophthalmopathy (GO), and that this receptor is not demonstrable in orbital tissues from normal indivi
Publikováno v:
Thyroid. 5:89-95
We and others have described previously a polymorphism at the first position of codon 52 (C52 --> A52) of the human thyrotropin receptor (hTSHr) gene. To determine its potential significance, we studied female (n = 100) and male (n = 25) patients wit
Publikováno v:
The Journal of clinical endocrinology and metabolism. 87(5)
The symptoms and signs of Graves' ophthalmopathy (GO) result from both an accumulation of hydrated hyaluronan in the orbital muscles and connective tissues and an expansion of the orbital adipose tissues. Recent studies have suggested a link between
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 11(3)
Graves' ophthalmopathy (GO) is an autoimmune disease characterized by an increase in the volume of the orbital fatty/connective tissues and extraocular muscles. This volume change is due to expansion of the adipose tissues and to accumulation of glyc
Publikováno v:
The Journal of clinical endocrinology and metabolism. 86(2)
Graves' ophthalmopathy (GO) is an orbital autoimmune disease that is closely associated with Graves' hyperthyroidism. Examination of retroorbital tissues in GO reveals an accumulation of glycosaminoglycans, increased fat volume, lymphocytic infiltrat
Autor:
R W, Valyasevi, D Z, Erickson, D A, Harteneck, C M, Dutton, A E, Heufelder, S C, Jyonouchi, R S, Bahn
Publikováno v:
The Journal of clinical endocrinology and metabolism. 84(7)
Although the autoantigen involved in Graves' hyperthyroidism is known to be the TSH receptor (TSHr), whether this antigen plays a primary role in the pathogenesis of Graves' ophthalmopathy (GO) is unclear. We sought to determine whether fibroblasts d
Publikováno v:
The Journal of clinical endocrinology and metabolism. 83(3)
It is acknowledged that the TSH receptor (TSHr) on thyroid follicular cells is the autoantigen involved in the hyperthyroidism of Graves' disease. However, whether this receptor is expressed in extrathyroidal tissues, and whether it participates dire
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 7(6)
Because the thyrotropin receptor (TSHR) has long been considered a thyroid-specific protein, its presence in extrathyroidal tissues has been controversial. In this study, we sought to detect and quantify this potentially low abundance mRNA in various
Publikováno v:
The Journal of clinical endocrinology and metabolism. 78(2)
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the associa
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 3(4)
Fibroblasts are target cells for the autoimmune process in Graves' ophthalmopathy and pretibial dermopathy. Because the autoantigen involved in the hyperthyroidism of Graves' disease is the TSH receptor, we sought to determine whether RNA encoding th