Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mark S. Cragg"'
Autor:
Christopher Rushton, Wolfram Klapper, Jonathan C. Strefford, Cathy Burton, Mark S. Cragg, Ryan D. Morin, Stephen A. Beers, Andrea Knapp, Malgorzata Nowicka, Christopher R. Bolen, Chern Lee, Chantal E. Hargreaves, Laura K. Hilton, Pedro Farinha, Matthew J. Carter, Margaret Ashton-Key, Matthew J. J. Rose-Zerilli, Kathleen N. Potter, Graham W. Slack, Maurizio Martelli, Christian Klein, Mikkel Z. Oestergaard, Umberto Vitolo, Laurie H. Sehn, Farheen Mir, Marek Trneny, Russell Foxall, David W. Scott
Publikováno v:
Blood Adv
Fc γ receptor IIB (FcγRIIB) is an inhibitory molecule capable of reducing antibody immunotherapy efficacy. We hypothesized its expression could confer resistance in patients with diffuse large B-cell lymphoma (DLBCL) treated with anti-CD20 monoclon
Autor:
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendéus, Ramsey I. Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Journal of Experimental & Clinical Cancer Research. 41
Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophages (TAMs)
Autor:
Florence Lambolez, Margreet Brouwer, Noémie Wald, Sofie Denies, Virginie Rabolli, Romain Pirson, Florence Nyawouame, Diane Jamart, Anne Marie-Cardine, Mathew J. Carter, Julie Preillon, Mark S. Cragg, Julie Déchanet-Merville, Shruthi Prasad, Erica Houthuys, Catherine Hoofd, Lucile Garnero, Vincent Pitard, Martine Bagot, Julia Cuende, Joao Marchante, Angela Pappalardo, Gregory Driessens, Marjorie Mercier, Reece Marillier, Anne-Catherine Michaux, Véronique Baron-Bodo
Publikováno v:
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
Molecular Cancer Therapeutics, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
TIGIT is an immune checkpoint inhibitor expressed by effector CD4 þ and CD8 þ T cells, NK cells, and regulatory T cells (Tregs). Inhibition of TIGIT-ligand binding using antagonistic anti-TIGIT mAbs has shown in vitro potential to restore T-cell fu
Autor:
Dorota Klaczkowska, Liselotte Bäckdahl, Rikard Holmdahl, Daniëlle Vaartjes, Kutty Selva Nandakumar, Mark S. Cragg
Publikováno v:
European Journal of Immunology
A haplotype with tightly linked Fc gamma receptor (FcγR) genes is known as a major locus controlling immune responses and autoimmune diseases, including arthritis. Here, we split a congenic fragment derived from the NOD mouse (Cia9) to study its eff
Autor:
Alexander P. Simpson, Ali Roghanian, Robert J. Oldham, H.T. Claude Chan, Christine A. Penfold, Hyung J. Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Yury D. Bogdanov, Sonya James, Alison L. Tutt, Daniel Rycroft, Peter Morley, Lekh N. Dahal, Ingrid Teige, Björn Frendeus, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Cell Reports. 40:111099
Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory FcγRIIB (CD32B). Dogma suggests inhibiti
Autor:
Mark S. Cragg, Kerry L. Cox, Vicentiu A Pitic, Robert J. Oldham, Patrick J. Duriez, C. Ian Mockridge, H.T. Claude Chan, Martin J. Glennie, Sonya James
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundImmune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as NOD SCID interleukin
Autor:
Thomas M. Kündig, Thomas Gruber, Monique Vogel, Federico Storni, Lisha Zha, Andris Zeltins, Mark S. Cragg, Paul Engeroff, Elisa S Roesti, Murray A. Skinner, Ina Balke, Martin F. Bachmann, Matthew D. Heath, Matthias F. Kramer, Diego von Werdt, Lukas Muri, Malgorzata Mlynarczyk
Publikováno v:
Storni, Federico; Zeltins, Andris; Balke, Ina; Heath, Matthew D; Kramer, Matthias F; Skinner, Murray A; Zha, Lisha; Rösti, Elisa; Engeroff, Paul; Muri, Lukas; von Werdt, Diego; Gruber, Thomas; Cragg, Mark; Mlynarczyk, Margrit; Kündig, Thomas M; Vogel, Monique; Bachmann, Martin (2020). Vaccine against peanut allergy based on engineered Virus-Like-Particles displaying single major peanut allergens. Journal of allergy and clinical immunology, 145(4), 1240-1253.e3. Elsevier 10.1016/j.jaci.2019.12.007
BackgroundPeanut allergy is a severe and increasingly frequent disease with high medical, psychosocial, and economic burden for affected patients and wider society. A causal, safe, and effective therapy is not yet available.ObjectiveWe sought to deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814358cd5c0a6f4d0e83f26c2892f9f9
Autor:
Jianzhu Chen, Matthew J. Meyer, Heather Huet, Margaret Ashton-Key, Russell Foxall, Stephen A. Beers, Stephen M. Thirdborough, Emma Lees, Guangan Hu, Ali Roghanian, Christopher Fraser, Mark S. Cragg, Sean H. Lim, Maneesh Singh, Martin J. Glennie
Publikováno v:
Cancer Immunol Res
Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in the periphery (e.g., sple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe73a0758b6fc9f363ed50fe942210e0
https://eprints.soton.ac.uk/434735/
https://eprints.soton.ac.uk/434735/
Autor:
Mei Cong, Maria J. Leandro, Patrick J. Duriez, Venkat Reddy, Brock Binkowski, Mark S. Cragg, H.T. Claude Chan, Robert J. Oldham, Geraldine Cambridge, Dun Li, Falk Nimmerjahn, Richard J. Stopforth, Philip G. Hargreaves, Alison L. Tutt, Anja Lux, Chad Zimprich
Publikováno v:
The Journal of Immunology. 200:1937-1950
Fc gamma receptors (FcγR) are involved in multiple aspects of immune cell regulation, are central to the success of monoclonal antibody (mAb) therapeutics and underpin the pathology of several autoimmune diseases. However, reliable assays capable of
Anti-FcγRIIB (CD32) Antibodies Differentially Modulate Murine FVIII-Specific Recall Responsein vitro
Publikováno v:
Scandinavian Journal of Immunology. 86:91-99
Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signaling pathways within immune cells. Data from a hemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitor