Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Natalia V. Bogatcheva"'
Autor:
Laila Imken, Alexander I. Agoulnik, Natalia V. Bogatcheva, Abdelhamid Barakat, Brahim El Houate, El bekkay Chadli, Hicham Sibai, Abdelaziz Chafik, Ken McElreavey, Hassan Rouba, Shu Feng
Publikováno v:
Journal of Urology. 177:1947-1951
Cryptorchidism affects 1% to 9% of full-term male neonates. Hypospadias is the second most frequent congenital anomaly seen in newborn males. These pathological conditions are part of the testicular dysgenesis syndrome. Insulin-like factor 3 and LGR8
Publikováno v:
Annals of the New York Academy of Sciences. 1041:82-90
We studied ligand-receptor interactions between relaxin (RLN), insulin-like 3 peptide (INSL3), and LGR7 and LGR8 receptors. The phenotypic effects of deficiency for Lgr7 and Lgr8 receptors, transgenic overexpression of Rln1 and Insl3, and different c
Autor:
Chester J. Koh, Brian E. Hardy, Shu Feng, Natalia V. Bogatcheva, Victoria K. Cortessis, Andrew H. Hwang, Alexander I. Agoulnik
Publikováno v:
Urology. 64:1032-1036
Objectives Male mice deficient in insulin-like 3 hormone (Insl3) or its receptor, Great/Lgr8, exhibit cryptorchidism. Recently, sequence analysis of the human INSL3 and GREAT genes identified several allelic variants. These include polymorphisms with
Autor:
Anne Truong, Shu Feng, Alexander I. Agoulnik, Natalia V. Bogatcheva, Wolfgang Engel, Ibrahim M. Adham
Publikováno v:
Molecular Endocrinology. 17:2639-2646
During male development testes descend from their embryonic intraabdominal position into the scrotum. Two genes, encoding the insulin-like 3 peptide (INSL3) and the GREAT/LGR8 G protein-coupled receptor, control the differentiation of gubernaculum, t
Autor:
Shu, Feng, Natalia V, Bogatcheva, Anne, Truong, Borys, Korchin, Colin E, Bishop, Thomas, Klonisch, Irina U, Agoulnik, Alexander I, Agoulnik
Publikováno v:
Biology of reproduction. 77(4)
The mutations of testicular insulin-like 3 (INSL3) hormone or its receptor RXFP2 cause cryptorchidism in male mice. Here we have examined Rxfp2 gene expression at different stages of embryonic and postnatal mouse development in male reproductive tiss
Autor:
Irina U. Agoulnik, Gustavo E. Ayala, Rile Li, Aparna A. Kamat, Bernard Kwabi-Addo, Alexander I. Agoulnik, Michael Ittmann, Shu Feng, Natalia V. Bogatcheva
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(6)
Purpose: To understand the role of relaxin peptide in prostate cancer, we analyzed the expression of relaxin and its receptor in human prostate cancer samples, the effects of relaxin signaling on cancer cell phenotype in vitro, and the effects of inc
Autor:
Irina U. Agoulnik, Donna Coffey, Aparna A. Kamat, Anil K. Sood, Alexander I. Agoulnik, Shu Feng, Natalia V. Bogatcheva, Farrah Kheradmand
Publikováno v:
Cancer biologytherapy. 5(1)
Relaxin (RLN) is a naturally occurring hormone that is known to modulate connective tissue remodeling in the uterus and cervix. Our goal was to investigate the role of RLN in endometrial cancer. RLN expression was evaluated using immunohistochemistry
Autor:
Colin E. Bishop, Aparna A. Kamat, Anne Truong, Shu Feng, Alexander I. Agoulnik, Natalia V. Bogatcheva
Publikováno v:
Endocrinology. 145(10)
Relaxin (RLN) is a small peptide hormone that affects a variety of biological processes. Rln1 knockout mice exhibit abnormal nipple development, prolonged parturition, agerelated pulmonary fibrosis, and abnormalities in the testes and prostate. We de