Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kunhong Xiao"'
Autor:
Irene Coin, Vasyl Bondarenko, Pei Tang, Ieva Sutkeviciute, Pemra Doruker, Frederic Jean-Alphonse, Fei Fang, Thore Böttke, Lisa J. Clark, Jean-Pierre Vilardaga, Saifei Lei, Thomas J. Gardella, Alex D. White, Kunhong Xiao, Ji Young Lee, Ivet Bahar, James Krieger
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩
Nature chemical biology
Nature Chemical Biology, Nature Publishing Group, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩
Nature chemical biology
International audience; Peptide ligands of class B G protein-coupled receptors (GPCRs) act via a two-step binding process, but the essential mechanisms that link their extracellular binding to intracellular receptor–arrestin interactions are not fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80067b92e1a48922060c62a5fda370ac
https://hal.archives-ouvertes.fr/hal-03117168
https://hal.archives-ouvertes.fr/hal-03117168
Autor:
Alex D, White, Frederic G, Jean-Alphonse, Fei, Fang, Karina A, Peña, Shi, Liu, Gabriele M, König, Asuka, Inoue, Despoina, Aslanoglou, Samuel H, Gellman, Evi, Kostenis, Kunhong, Xiao, Jean-Pierre, Vilardaga
Publikováno v:
Proc Natl Acad Sci U S A
cAMP production upon activation of G(s) by G protein-coupled receptors has classically been considered to be plasma membrane-delimited, but a shift in this paradigm has occurred in recent years with the identification of several receptors that contin
Autor:
Jin-Peng Sun, Kunhong Xiao
Publikováno v:
Cellular Signalling. 41:56-64
The discovery of β-arrestin-dependent GPCR signaling has led to an exciting new field in GPCR pharmacology: to develop "biased agonists" that can selectively target a specific downstream signaling pathway that elicits beneficial therapeutic effects
Autor:
Lupei Du, Duxiao Yang, Jin-Peng Sun, Xiao Yu, Mengyuan Zhu, Kunhong Xiao, Keng-chang Tsai, Ang Li
Publikováno v:
Future Medicinal Chemistry. 7:2429-2437
Background: Free fatty acid 4 (FFA4) (GPR120) receptor functions as a receptor for unsaturated long-chain free fatty acids by regulating the secretion of glucagon-like peptide-1 and suppressing the inflammatory process, in which these two distinct bi
Publikováno v:
Journal of Receptors and Signal Transduction. 35:213-219
Mass spectrometry (MS)-based proteomics is an unrivaled tool for studying complex biological systems and diseases in the post-genomic era. In recent years, MS has emerged as a powerful structural biological tool to characterize protein conformation a
Autor:
Vanessa L. Wehbi, Jingming Chen, Masaki Noda, Juan M. Taboas, Kunhong Xiao, Jean-Pierre Vilardaga, Frederic Jean-Alphonse
Publikováno v:
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩
Nature Chemical Biology, Nature Publishing Group, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩
International audience; Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d1de34a5dcf3d2aadc1f153c8610a5
https://hal.archives-ouvertes.fr/hal-03117157
https://hal.archives-ouvertes.fr/hal-03117157
Autor:
Sachdev S. Sidhu, Brian K. Kobilka, Xin Chen, Li-Yin Huang, Arun K. Shukla, Austin N. Oleskie, Minjung Choi, Sheng Li, Ling Ling Gu, Anthony A. Kossiakoff, Jiang Qian, Gerwin Westfield, Rosana I. Reis, Robert J. Lefkowitz, Shohei Koide, Alem W. Kahsai, Georgios Skiniotis, Jin Ming Shan, Adi Blanc, Prachi Tripathi-Shukla, Pawel A. Penczek, Cui Rong Liang, Rachel Hanna, Anne M. Dosey, Bjoern U. Klink, Xiao Jie Yao, Kunhong Xiao, Min Su, Virgil L. Woods
Publikováno v:
Nature
Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex. Much has been learned about the structure of G-protein-cou
Publikováno v:
Current Opinion in Cell Biology. 27:18-24
The classic paradigm of G protein-coupled receptor (GPCR) activation was based on the understanding that agonist binding to a receptor induces or stabilizes a conformational change to an “active” conformation. In the past decade, however, it has
Autor:
Chen Song, Fahui Li, Zheng Gong, Hongda Liu, Kunhong Xiao, Changlin Tian, Dongfang He, Chuan Liu, Fan Yi, Hong-Mei Wang, Fan Yang, Changxiu Qu, Jin-Peng Sun, Xiao Yu, Jiangyun Wang
Publikováno v:
Nature Communications
Specific arrestin conformations are coupled to distinct downstream effectors, which underlie the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino acid incorporation and fluorine-19 nuclear magnetic resonance (19F-NMR
β-arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G protein-coupled receptors [GPCRs]), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c103e0320fcb42b01661f971be223d
https://europepmc.org/articles/PMC3168679/
https://europepmc.org/articles/PMC3168679/